P09 Prof. Dr. Tacke
Monozyten und Makrophagen Subpopulationen in der Leberfibrose
Die Entzündungsreaktion im chronischen Leberschaden induziert Fibrose. Mit experimentellen Mausmodellen und humanen Proben untersuchen wir die funktionelle Rolle von Monozyten- und Makrophagen-Subpopulationen für die Progression und Regression der Leberfibrose und entwickeln neue Strategien zur gezielten therapeutischen Beeinflussung der Monozyten- und Makrophagen-Subtypen in der Fibroseentwicklung. [...]
Leberfibrose als gestörter Wundheilungsprozess chronischer Lebererkrankungen wird vor allem durch eine persistierende Entzündungsreaktion unterhalten. Hepatische Makrophagen erfüllen entscheidende Funktionen in der geschädigten Leber, weil sie zum einen Entzündung, Fibrose und Angiogenese, zum anderen aber auch die Resolution einer Fibrose vermitteln können. In unserem Projekt konnten wir die unterschiedlichen Beiträge verschiedener Makrophagen-Populationen in der Leber, insbesondere der Leber-eigenen Kupffer-Zellen und der Monozyten-abhängigen infiltrierenden Makrophagen, in der Fibrose-Progression und –Regression nachweisen. Beispielsweise konnten wir die Rekrutierung inflammatorischer Monozyten über den Chemokinrezeptor CCR2 und das Chemokin CCL2 in Mausmodellen der Leberfibrose identifizieren. Wir haben zudem ein intravitales Multiphotonen-Mikroskopie-System etabliert, welches die direkte Beobachtung der Infiltration von Monozyten-/Makrophagen-Subpopulationen in die geschädigte Leber in Mausmodellen ermöglicht. Unsere erfolgreichen Ansätze zur Hemmung der Monozyten-Infiltration in Tiermodellen der Leberfibrose werden aktuell in einer multizentrischen Phase II Studie (Centaur Studie, nationaler Koordinator: Frank Tacke) mit dem Chemokinrezeptor CCR2/CCR5 Inhibitor Cenicriviroc in Patienten mit nicht-alkoholischer Steatohepatitis und Leberfibrose evaluiert.
Wichtige Fragestellungen unseres Projekts sind:
- Relevanz von Leber-residenten Makrophagen (Kupffer-Zellen) gegenüber infiltrierenden Monozyten-abhängigen Makrophagen in Homöostase und Lebererkrankungen
- Molekulare Faktoren zur Rekrutierung von Monozyten (z.B. Chemokine)
- Molekulare Faktoren zur Differenzierung von Makrophagen-Subpopulationen in der Progression und Regression der Leberfibrose
- Interaktionen von Makrophagen-Subtypen mit anderen Leberzellen (z.B. Kollagen-produzierende Sternzellen) und mit anderen Immunzellen (z.B. NKT Zellen)
- Funktionelle Rolle hepatischer Makrophagen-Subpopulationen Subpopulationen in der Progression und Regression der Leberfibrose
- Therapeutische Modulation von Monozyten-/Makrophagen-Subpopulationen in Lebererkrankungen
- Translation der Ergebnisse aus Mausmodellen für die humane Pathophysiologie, insbesondere Identifikation von Makrophagen-Subtypen in gesunder und fibrotischer humaner Leber
Ziel dieses Projektes ist die Aufklärung der funktionellen Beiträge verschiedener Monozyten- und Makrophagen-Subpopulationen in der Progression und Regression der Leberfibrose in Mausmodellen und Patienten mit Lebererkrankungen, die Identifikation der molekularen und zellulären Faktoren für die funktionelle Differenzierung von Makrophagen in der Leberfibrose und die Entwicklung sowie Überprüfung neuer Strategien zur therapeutischen Modulation von Monozyten- und Makrophagen-Subpopulationen zur Behandlung der Leberfibrose.
Publikationen
- Loosen S. H. , Schulze-Hagen M., Püngel T., Bündgens L., Wirtz T., Kather J. N., Vucur M., Paffenholz P., Demir M., Bruners P., Kuhl C., Trautwein C., Tacke F., Luedde T., Koch A., Roderburg C. (2020): Skeletal muscle composition predicts outcome in criticalliy ill patients. Critical Care Explorations, 2(8),
- Yagmur E. , Otto S., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Decreased CTRP3 plasma concentrations are associated wtih sepsis and predict mortality in critically ill patients. Diagnostics, 9, 63, [2.489]
- Yagmur E. , Buergerhausen D., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Elevated CTRP1 plasma concentration is associated with sepsis and pre-existing type 2 diabetes mellitus in critically ill patients. J Clin Med, 8, 661, [5.583]
- Yagmur E. , Bast E., Mühlfeld A. S., Koch A., Weiskirchen R., Tacke F., Neulen J. (2019): High prevalence of sticky platelet syndrome in patients with infertility and pregnancy loss. J Clin Med, 8, 1328, [5.583]
- Weiskirchen R. , Tacke F. (2019): Pathophysiologie: Immunologie.“ Nichtalkoholische Fettleber. (Eds. Andreas Geier, Ali Canbay & Frank Lammert). Springer Verlag, im Druck, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic fibrogenesis. Encyclopedia of Gastroenterology, 2nd Edition, Elsevier, New York, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic Fibrogenesis. Reference Module in Biomedical Sciences, , 1-7, [0.200]
- Weiskirchen R. , Tacke F. (2019): Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease. Cells, 8, 16, [5.656]
- Tacke F. , Spehlmann M.E., Vucur M., Benz F., Luedde M., Cardenas D.V., Roy S., Loosen S, Hippe H.J., Frey N., Trautwein C., Koch A., Roderburg C., Luedde T. (2019): miR-155 predicts lpongterm mortality in critically ill patiens younger than 65 years. Mediators Inflamm, [3.549]
- Roy S. , Hooiveld G. J., Seehawer M., Caruso S., Heinzmann F., Schneider A. T., Frank A. K., Vargas Cardenas D., Sonntag R., Luedde M., Trautwein C., Stein I., Pikarsky E., Loosen S., Tacke F., Ringelhan M., Avsaroglu S. K.,Goga A., Buendia M.-A., Vucur M., Heikenwalder M., Zucman-Rossi J., Zender L., Roderburg C., Luedde T. (2019): microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology, 155(6), 1951–1966, [20.773]
- Puelles V. G. , Fleck D., Ortz L., Papadouri S., Strieder T., Boehner A., van der Wolde J. W., Vogt M., Saritas T., Kuppe C., Fuss A., Menzel S., Klinkhammer B. M., Müller-Newen G., Heymann F., Decker L., Braun F., Kretz O., Huber T. B., Susaki E. A., Ueda H. R., Boor P., Floege J., Kramann R., Kurts C., Bertram J. F., Spehr M., Nikolic-Paterson D. J., Moeller M. J. (2019): 3D analysis of rapidly progressive glomerulonephritis using optical tissue clearing. Kidney Int, 96, 505-516, [8.306]
- Mossanen J. C. , Kohlhepp M., Wehr A., Krenkel O., Liepelt A., Roeth A. A., Möckel D., Heymann F., Lammers T., Gassler N., Hermann J., Jankowski J., Neumann U. P., Luedde T., Trautwein C., Tacke F. (2019): CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence. Gastroenterology, 156(6), 1877-1889, [20.773]
- Loosen S.H. , Koch A., Tacke F., Roderburg C., Luedde T. (2019): The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. Int J Mol Sci, 20(19), 4820, [4.183]
- Loosen S.H. , Schulze-Hagen M., Bruners P., Tacke F., Trautwein C., Kuhl C., Luedde T., Roderburg C. (2019): Sarcopenia Is a Negative Prognostic Factor in Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatic Malignancies. Cancers, 11(10), 1503, [6.162]
- Mahli A. , Seitz T., Fresse K., Frank J., Weiskirchen R., Abdel-Tawab M., Behnam D., Hellerbrand C. (2019): Therapeutic application of micellar solubilized xanthohumol in a Western-type diet-induced mouse model of obesity, diabetes and non-alcoholic fatty liver disease. Cells, 8, 359, [5.656]
- Loosen S. H. , Tacke F., Püthe N., Binneboesel M., Wiltberger G., Alizai P. H., Kather J. N., Paffenholz P., Ritz T., Koch A., Bergmann F., Trautwein C., Longerich T., Roderburg C., Neumann U. P., Luedde T. (2019): High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma. Carcinogenesis, 40(8), 947–955, [4.004]
- Loosen S. H. , Lurje G., Wiltberger G., Vucur M., Koch A., Kather J. N., Paffenholz P., Tacke F., Ulmer F. T., Trautwein C. (2019): Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma. PLoS ONE, 14 (1), e0210944, [2.776]
- Loosen S. H. , Hoening P., Puethe N., Luedde M., Spehlmann M., Ulmer T. F., Cardenas D. V., Roy S., Tacke F., Trautwein C., Neumann U. P., Luedde T., Roderburg C. (2019): Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma. Sci Rep., 9(1), 1489, [4.011]
- Krenkel O. , Hundertmark J., Ritz T.P., Weiskirchen R., Tacke F. (2019): Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis. Cells, 8, 503, [5.656]
- Koppe C. , Reisinger F., Wehr K., Vucur M., Trautwein C., Tacke F., Heikenwalder M., Luedde T. (2019): An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration. Cancers, 11(7), 999, [6.162]
- Kather J. N. , Pearson A. T., Halama N., Jäger D., Krause J., Loosen S. H., Marx A., Boor P., Tacke F., Neumann U. P., Grabsch H. I., Yoshikawa T., Brenner H. B., Chang-Claude J., Hoffmeister M., Trautwein C., Luedde T. (2019): Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med, 25, 1054-1056, [30.641]
- Hohlstein P. , Gussen H., Bartneck M., Warzecha K. T., Roderburg C., Buendgens L., Trautwein C., Koch A., Tacke F. (2019): Prognostic Relevance of Altered Lymphocyte Subpopulations in Critical Illness and Sepsis. Journal of Clinical Medicine, [5.688]
- Heymann F. , von Trotha K.-T., Preisinger C., Lynen-Jansen P., Roeth A. A., Geiger M., Geisler L. J., Frank A. K., Conze J., Luedde T., Trautwein C., Binnebösel M., Neumann U. P., Tacke F. (2019): Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation. JCI insight, [6.014]
- Gussen H. , Hohlstein P., Bartneck M., Warzecha K. T., Buendgens L., Luedde T., Trautwein C., Koch A., Tacke F. (2019): Neutrophils are a main source of circulating suPAR predicting outcome in critical illness. J Intensive Care, 7, 26, [3.510]
- Guillot A. , Tacke F. (2019): Liver Macrophages: Old Dogmas and New Insights. Hepatol Commun., 3 (6), 730-743, [0.800]
- Bartneck M. , Schrammen P. L., Möckel D., Govaere O., Liepelt A., Krenkel O., Ergen C., McCain M. V., Eulberg D., Luedde T., Trautwein C., Kiessling F., Reeves H., Lammers T., Tacke F. (2019): The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers. Cell Mol Gastroenterol Hepatol, 7(2), 371-390, [6.850]
- Yagmur E. , Buendgens L., Herbers U., Beeretz A., Weiskirchen R., Koek G. H., Trautwein C., Tacke F., Koch A. (2018): High mobility group box 1 as a biomarker in critically ill patients. J Clin Lab Anal, 32(8), e22584, [1.728]
- Weiskirchen R. , Tacke F. (2018): The role of radiologic modalities in diagnosing non-alcoholic steatohepatitis (NASH) and fibrosis. Curr Hepat Rep, 17, 324-335, [0.200]
- Warzecha K. T. , Bartneck M., Möckel D., Appold L., Ergen C., Al Rawashdeh W., Gremse F., Niemietz P. M., Jahnen‐Dechent W., Trautwein C., Kiessling F., Lammers T., Tacke F. (2018): Targeting and Modulation of Liver Myeloid Immune Cells by Hard-Shell Microbubbles. Adv Biosyst, 2(5), 1-24, [2.855]
- Vucur M. , Roderburg C., Kaiser L., Schneider A. T., Roy S., Loosen S. H., Luedde M., Trautwein C., Koch A., Tacke F., Luedde T. (2018): Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Dis Markers, , 1983421, [2.761]
- Tacke F. , Weiskirchen R. (2018): An update on the recent advances in antifibrotic therapies. Exp Rev Gastroenterol Hepatol, 12(11), 1143-1152, [2.991]
- Puengel T. , Tacke F. (2018): Repair macrophages in acute liver failure. Gut, 67(2), 202-203, [17.160]
- Pombeiro I. , Loosen S. H, Roy S., Schueller F., Niewenhuisen L., Luedde M., Vucur M., Tacke F., Binnebösel M., Schoening W., Trautwein C., Luedde T., Neumann U. P., Roderburg C. (2018): Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer. J Clin Med, 7(7), 175, [5.583]
- Moellmann J. , Klinkhammer B. M., Onstein J., Stöhr R., Jankowski V., Jankowski J., Lebherz C., Tacke F., Marx N., Boor P., Lehrke M. (2018): Glucagon-like peptide-1 and its cleavage products are renoprotective in murine diabetic nephropathy. Diabetes, 67(11), 2410-2419, [7.199]
- Luedde M. , Spehlmann M. E., Hippe H.-J., Loosen S. H., Roy S., Cardenas D. V., Vucur M., Frey N., Koch A., Luedde T., Trautwein C., Tacke F., Roderburg C. (2018): Serum levels of kisspeptin are elevated in critically ill patients. PLoS ONE, 13(10), e0206064, [2.776]
- Loosen S. H. , Tacke F., Binnebosel M., Leyh C., Vucur M., Heitkamp F., Schoening W., Ulmer T. F., Alizai P. H., Trautwein C., Koch A., Longerich T., Roderburg C., Neumann U. P., Luedde T. (2018): Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases. Oncotarget, 9(43), 27027-27038, [5.168]
- Loosen S. H. , Schulze-Hagen M., Leyh C., Benz F., Vucur M., Kuhl C., Trautwein C., Tacke F., Bruners P., Roderburg C., Luedde T. (2018): IL-6 and IL-8 Serum Levels Predict Tumor Response and Overall Survival after TACE for Primary and Secondary Hepatic Malignancies. Int J Mol Sci, 19(6), 1766, [4.183]
- Koch A. , Yagmur E., Linka J., Schumacher F., Bruensing J., Buendgens L., Herbers U., Koek G. H., Weiskirchen R., Trautwein C., Tacke F. (2018): High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients. Dis Markers, 8583121, [2.761]
- Koch A. , Yagmur E., Hoss A., Buendgens L., Herbers U., Weiskirchen R., Koek G. H., Trautwein C., Tacke F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J Clin Lab Anal, , e22614, [1.728]
- Koch A. , Weiskirchen R., Krusch A., Bruensing J., Buendgens L., Herbers U., Yagmur E., Koek G. H., Trautwein C., Tacke F. (2018): Visfatin serum levels predict mortality in critically ill patients. Dis Markers, 7315356, [2.761]
- Gauthier A. , Fisch A., Seuwen K., Baumgarten B., Ruffner H., Aebi A., Rausch M., Bartneck M., Weiskirchen R., Tacke F., Storm G., Lammers T., Ludwig M.-G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials, 178, 481-495, [10.273]
- Vucur, M. , Roderburg, C., Kaiser, L., Schneider, A.T., Roy, S., Loosen, S., Luedde, M., Trautwein, C., Koch, A., Tacke, F., Luedde, T. (2017): Elevated serum levels of the mixed lineage kinase domain-like protein (MLKL) predict survival of patients during intensive care unit treatment. Hindawi, [2.348]
- Loosen, S.H. , Roderburg, C., Kauertz, K.L., Koch, A., Vucur, M., Schneider, A.T., Binnebösel, M., Ulmer, T.F., Lurje, G., Schoening, W., Tacke, F., Trautwein, C., Longerich, T., Dejong, C.H., Neumann, U.P., Luedde, T. (2017): CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma. Scientific Reports, 7, [5.228]
- Bangen, J.M. , Hammerich, L., Sonntag, R., Baues, M., Haas, U., Lambertz, D., Longerich, T., Lammers, T., Tacke, F., Trautwein, C., Liedtke C. (2017): Targeting CCl4 -induced liver fibrosis by RNA interference-mediated inhibition of cyclin E1 in mice. Hepatology, 66 (4), 1242-1257, [13.246]
- Puengel, T. , Krenkel, O., Kohlhepp, M., Lefebvre, E., Luedde, T., Trautwein, C., Tacke, F. (2017): Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury. PLoS One, [3.057]
- Buendgens, L. , Yagmur, E., Bruensing, J., Herbers, U., Baeck, C., Trautwein, C., Koch, A., Tacke, F. (2017): Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Disease Markers, 18, [2.348]
- Bábíčková J. , Klinkhammer B.M., Buhl E.M., Djudjaj S., Hoss M., Heymann F., Tacke F., Floege J., Becker J.U., Boor P. (2017): Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney International, 91(1), 70-85, [7.683]
- Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F (2017): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44, [2.053]
- Mossanen, J. , Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., Luedde, T., Marx, G., Strassburg, C., Roskams, T., Trautwein, C., Tacke, F. (2017): CCR2+ monocytes aggravate the early phase of acetaminophen induced acute liver injury. Journal of Hepathology, 64(5), 1667–1682, [10.590]
- Schneider, A. , Gautheron, J., Feoktistova, M., Roderburg, C., Loosen, S. H., Roy, S., Benz, F., Schemmer, P., Büchler, M. W., Nachbur, U., Neumann, U. P., Tolba, R., Luedde, M., Zucman-Rossi, J., Panayotova-Dimitrova, D., Leverkus, M., Preisinger, C., Tacke, F., Trautwein, C., Longerich, T., Vucur, M., Luedde, T. (2017): RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell, 31 (1), 94–109, [23.214]
- Strnad, P. , Tacke, F., Koch, A., Trautwein (2017): Liver - guardian, modifier and target of sepsis. Nature Reviews Gastroenterology & Hepatology, 14(1), 55-66, [14.435]
- Weiskirchen R. , Tacke F. (2017): Interleukin-33 in the pathogenesis of liver fibrosis: alarming ILC2 and hepatic stellate cells. Cellular & Molecular Immunology, 14 (2), 143-145, [5.193]
- Weiskirchen S. , Tag C.G., Sauer-Lehnen S., Tacke F., Weiskirchen R. (2017): Isolation and culture of primary murine hepatic stellate cells. Methods in Molecular Biology, 1627, 165-191, [1.170]
- Koppe C. , Verheuged P., Gautheron J., Reisinger F., Kreggenwinkel K., Roderburg C., Quagliata L., Terracciano L., Gassler N., Tolba R., Boege Y., Weber A., Karin M., Luedde M., Neumann U. P., Weiskirchen R., Tacke F., Vucur M., Trautwein C., Lüscher B., Preisinger C., Heikenwälder M., Lüdde T. (2016): IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylation the cell death mediator RIPK1. Hepatology, 64 (4), 1217-1231, [11.711]
- Ju C. , Tacke F. (2016): Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cellular & Molecular Immunology, 13, 315-327, [5.193]
- Jansen, C. (2016): Algorithm to rule-out clinically significant portal hypertension combining Shear-wave elastography of liver and spleen: a prospective multi-center study. Gut, 65 (6), 1057-1058, [14.660]
- Tacke, F. (2016): Biomarker and Therapeutic Potential of CSF1 in Acute Liver Failure.. Gastroenterology, 149 (7), 1675-1678, [18.187]
- Tacke F. , Nuraldeen R., Koch A., Strathmann K., Hutschenreuter G., Trautwein C., Strnad P. (2016): Iron Parameters Determine the Prognosis of Critically Ill Patients. Critical Care Medicine, 44 (6), 1049-1058, [7.422]
- Shirvani-Dastgerdi, E. , Pourkarim M.R., Herbers U., Amini-Bavil-Olyaee S., Yagmur E., Alavian S.M., Trautwein C., Tacke F (2016): Hepatitis delta virus facilitates the selection of hepatitis B virus mutants in vivo and functionally impacts on their replicative capacity in vitro.. Clinical Microbiology and Infection, 22(1), e1-6, [5.575]
- Schon H.T. , Bartneck M., Borkham-Kamphorst E., Nattermann J., Lammers T., Tacke F., Weiskirchen R. (2016): Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis. Frontiers in Pharmacology, 7, 33, [4.418]
- Nevzorova, Y. A. , Cubero F.J., Hu W., Hao F., Haas U., Ramadori P., Gassler N., Hoss M., Strnad P., Zimmermann H.W., Tacke F., Trautwein C., Liedtke C. (2016): Enhanced expression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease. J Hepatology, 64(3), 628-40, [11.340]
- Weiskirchen R. , Tacke F. (2016): Liver fibrosis – which mechanisms matter?. Clinical Liver Disease, 8 (4), 94-99, [0.360]
- Heymann F. , Tacke F. (2016): Immunology in the liver - from homeostasis to disease. Nat Rev Gastroenterol Hepatol, 13(2), 88-110, [14.435]
- Hartmann P. , Tacke F. (2016): Tiny RNA with great effects: miR-155 in alcoholic liver disease. Journal of Hepatology, 64 (6), 1214-1216, [10.590]
- Bartneck M. , Fech V., Ehling J., Govaere O., Theresa Warzecha K., Hittatiya K., Vucur M., Gautheron J., Luedde T., Trautwein C., Lammers T., Roskams T., Jahnen-Dechent W., Tacke F. (2016): Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease. Hepatology, 63(4), 1310-24,
- Weiskirchen, R. , Tacke, F. (2016): Neue Therapieoptionen für die Leberfibrose: Aus der Forschung in die Klinik. New treatment options for liver fibrosis: From-bench-to-bedside.. Der Gastroenterologe, 11, 40-46, [0.200]
- Asimakopoulou, A. , Borkham-Kamphorst, E., Tacke, F., Weiskirchen, R. (2016): Lipocalin-2 (NGAL/LCN2), a "HELP-ME" signal in organ inflammation.. Hepatology, 63, 669-671, [11.711]
- Weiskirchen, R. , Tacke, F. (2016): Liver fibrosis: from pathogenesis to novel therapies.. Digestive Diseases and Sciences, 34, 410-422, [2.516]
- Weiskirchen R. , Tacke F. (2016): Leberfibrose: von der Pathologie zu den Therapiemöglichkeiten. Falk Gastro-Kolleg., , 1-11, [0.200]
- Wehr, A. (2015): The Roles of CXCL16 and CXCR6 in Liver Inflammation and Fibrosis. Curr Pathobiol Rep, 3 (4), 283-290,
- Tacke, F. (2015): Mechanisms of liver fibrosis resolution.. J Hepatol, [11.340]
- Shirvani-Dastgerdi, E. , Tacke, F. (2015): Molecular interactions between hepatitis B virus and delta virus.. World Journal of Virology, 4 (2), 36-41,
- Shirvani-Dastgerdi, E. , Amini-Bavil-Olyaee, S., Alavin, S.M., Trautwein, C., Tacke, F. (2015): Comprehensive analysis of mutations in the hepatitis delta virus genome based on full-length sequencing in a nationwide cohort study and evolutionary pattern during disease progression.. Clinical Microbiology and Infection, 21 (5), 510e11-510.e23, [4.575]
- Schneider, K. M. , Bieghs V., Heymann F., Hu W., Dreymueller D., Liao L., Frissen M., Ludwig A., Gassler N., Pabst O., Latz E., Sellge G., Penders J., Tacke F., Trautwein C. (2015): CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis.. Hepatology, 62 (5), 1405-1416, [11.711]
- Schierwagen R. , Maybüchen L, Zimmer S, Hittatiya K, Bäck C, Klein S, Uschner FE, Reul W, Boor P, Nickenig G, Strassburg CP, Trautwein C, Plat J, Lütjohann D, Sauerbruch T, Tacke F, Trebicka J. (2015): Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Scientific Reports, 5, 3456-64, [5.228]
- Roy, S. , Benz, F., Vargas Cardenas, D., Vucur, M., Gautheron, J., Schneider, A., Hellerbrand, C., Pottier, N., Alder, J., Tacke, F., Trautwein, C., Roderburg, C., Luedde, T. (2015): miR-30c and miR-193 are a part of the TGF-β-dependent regulatory network controlling extracellular matrix genes in liver fibrosis.. Journal of Digestive Diseases, 16 (9), 513-524, [1.887]
- Roderburg, C. , Benz, F., Cardenas, D.V., Lutz, M., Hippe, H.J., Luedde, T., Trautwein, C., Tacke, F., Luedde, M. (2015): Persistently elevated osteopontin serum levels predict mortality in critically ill patients.. Crit Care, 19, 271, [4.950]
- Roderburg, C. , Benz, F., Vargas Cardenas, D., Koch, A., Janssen, J., Vucur, M., Gautheron, J., Schneider, A.T., Koppe, C., Kreggenwinkel, K., Zimmermann, H.W., Luedde, M., Trautwein, C., Tacker F., Luedde, T. (2015): Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases.. Liver Int, 35 (4), 1182-1184, [4.470]
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- Koch, A. , Sanson, E., Voigt, S., Helm, A., Trautwein, C., Tacke, F. (2011): Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients. Journal of Critical Care, 26, 166-174, [2.445]
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- Koch, A. , Horn, A., Duckers, H., Yagmur, E., Sanson, E., Bruensing, J., Buendgens, L., Voigt, S., Trautwein, C., Tacke, F. (2011): Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Critical Care, 15, R266, [4.950]
- Henkel, C. , Schwamborn, K., Zimmermann, H. W., Tacke, F., Kuhnen, E., Odenthal, M., Groseclose, M. R., Caprioli, R. M., Weiskirchen, R. (2011): From proteomic multimarker profiling to interesting proteins: thymosin-beta(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions. Journal of Cellular an Molecular Medicine, 15 (10), 2176-2188, [4.938]
- Berres, M. L. , Trautwein, C., Schmeding, M., Eurich, D., Tacke, F., Bahra, M., Neuhaus, P., Neumann, U. P., Wasmuth, H. E. (2011): Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection. Hepatology, 53 (2), 596-603, [11.711]
- Hammerich, L. , Heymann, F., Tacke, F. (2011): Role of IL-17 and Th17 cells in liver diseases. Clinical and Developmental Immunology, [3.603]
- Amini-Bavil-Olyaee, S. , Pourkarim, M. R., Schaefer, S., Mahboudi, F., Van Ranst, M., Adeli, A., Trautwein, C., Tacke, F. (2011): Single-step real-time PCR to quantify hepatitis B virus and distinguish genotype D from non-D genotypes. Journal of Viral Hepatology, 18, 300-304, [4.179]
- Zimmermann, H. W. , Seidler, S., Nattermann, J., Gassler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J., Luedde, T., Weiskirchen, R., Trautwein, C., Tacke, F. (2010): Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One, 5 (6), e11049, [3.057]
- Sahin, H. , Trautwein, C., Wasmuth, H. E. (2010): Functional role of chemokines in liver disease models. Nat Rev Gastroenterol Hepatol, 7 (12), 682-690, [14.435]
- Vucur, M. , Roderburg, C., Bettermann, K., Tacke, F., Heikenwalder, M., Trautwein, C., Luedde, T. (2010): Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?. Oncotarget, 1 (5), 373-378, [5.008]
- Tacke F , Weiskirchen R. (2010): Liver fibrosis - pathogenesis and novel therapeutic approaches. Der Internist, 51 (1), 21-29, [0.336]
- Seidler, S. , Zimmermann, H. W., Bartneck, M., Trautwein, C., Tacke, F. (2010): Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults.. BMC Immunol, 11, 30, [2.161]
- Koch, A. , Weiskirchen, R., Zimmermann, H. W., Sanson, E., Trautwein, C., Tacke, F. (2010): Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators of Inflammation, [3.418]
- Koch, A. , Weiskirchen, R., Sanson, E., Zimmermann, H. W., Voigt, S., Duckers, H., Trautwein, C., Tacke, F. (2010): Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation. Crit Care, 14, R179, [4.950]
- Karlmark, K. R. , Zimmermann, H. W., Roderburg, C., Gassler, N., Wasmuth, H. E., Luedde, T., Trautwein, C., Tacke, F. (2010): The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology, 52 (5), 1769-1782, [11.711]
- Bomble, M. , Tacke, F., Rink, L., Kovalenko, E., Weiskirchen, R. (2010): Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts. Biochem Biophys Res Commun, 396, 342-347, [2.371]
- Bettermann, K. , Vucur, M., Haybaeck, J., Koppe, C., Janssen, J., Heymann, F., Weber, A., Weiskirchen, R., Liedtke, C., Gassler, N., Muller, M., de Vos, R., Wolf, M. J., Boege, Y., Seleznik, G. M., Zeller, N., Erny, D., Fuchs, T., Zoller, S., Cairo, S., Buendia, M. A., Prinz, M., Akira, S., Tacke, F., Heikenwalder, M., Trautwein, C., Luedde, T. (2010): TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell, 17 (5), 481-496, [23.214]
- Amini-Bavil-Olyaee, S. , Vucur, M., Luedde, T., Trautwein, C., Tacke, F. (2010): Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains. Journal of Virology, 84 (29, 1026-1033, [4.606]
- Wasmuth, H. E , Tag, C. G., Van de Leur, E., Hellerbrand, C., Mueller, T., Berg, T., Puhl, G., Neuhaus, P., Samuel, D., Trautwein, C., Kanse, S. M., Weiskirchen, R. (2009): The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.. Hepatology, 49, 775-780, [11.711]
- Nattermann, J. , Tacke, F. (2009): The structure behind diversity: covariance networks in hepatitis C virus sequences are associated with treatment response.. Hepatology, 49, 1767-1769, [11.711]
- Kovalenko, E. , Tacke, F., Gressner, O. A., Zimmermann, H. W., Lahme, B., Janetzko, A., Wiederholt, T., Berg, T., Muller, T., Trautwein, C., Gressner, A. M., Weiskirchen, R. (2009): Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.. J Viral Hepat, 16, 612-620, [4.179]
- Koch, A. , Gressner, O. A., Sanson, E., Tacke, F., Trautwein, C. (2009): Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients.. Crit Care, 13, R95, [4.950]
- Karlmark, K. R. , Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., Tacke, F (2009): Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology, 50, 261-274, [11.711]
- Heymann, F. , Trautwein, C., Tacke, F. (2009): Monocytes and macrophages as cellular targets in liver fibrosis. Inflamm Allergy Drug Targets, 8, 307-318, [1.560]
- Berres, M. L. , Trautwein, C., Zaldivar, M. M., Schmitz, P., Pauels, K., Lira, S. A., Tacke, F., Wasmuth, H. E. (2009): The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biol Chem, 390, 1039-1045, [2.710]
- Amini-Bavil-Olyaee, S. , Herbers, U., Mohebbi, S. R., Sabahi, F., Zali, M. R., Luedde, T., Trautwein, C., Tacke, F. (2009): Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome. J Hepatol, 51, 647-654, [10.590]