Q03 Prof. Dr. Weiskirchen
FACS-basierte Zellisolation und klinische Translation
Die Q3 Zentraleinheit versorgt die Projekte zuverlässig, standardisiert und effizient mit primären Leber- und Nierenzellen aus Maus und Ratte. FACS-basierte Protokolle wurden zur Isolation primärer hepatischer Sternzellen, sinusoidaler Endothelzellen sowie von renalen Podozyten und Parietalzellen entwickelt. Aktuell werden die Protokolle auf humanes Material für translationale Projekte ausgedehnt. [...]
Die Q3 Core Facility hat für die Teilprojekte des SFB/TRR57 zahlreiche innovative Techniken für die Isolation primärer Zellen aus Lebern und Nieren von Maus und Ratte etabliert, um den Teilprojekten für ihre Fragestellungen zuverlässig, standardisiert und kosteneffizient hoch-reine Zellpopulationen bereitzustellen. Mit konventionellen Methoden werden routinemäßig primäre hepatische Sternzellen und Hepatozyten für die Teilprojekte in Aachen und Bonn isoliert. Zudem haben wir ein neues FACS-basiertes Protokoll zur Aufreinigung hoch-reiner Sternzellpopulationen etabliert, welches auf der UV-Autofluoreszenz im Durchflusszytometer-Sorter basiert. Weitere Protokolle, sowohl FACS- als auch MACS-basiert, wurden gemeinsam mit den Teilprojektleiter/innen für verschiedene Nieren-Zelltypen (Podozyten, Parietalzellen, Makrophagen/dendritische Zellen), hepatisches sinusoidales Endothel, Ovalzellen und hepatische / renale Immunzellen aus Maus und Ratte etabliert.
Derzeit erweitern wir dieses Methodenspektrum auf humanes Material für translationale Fragestellungen. Hierzu gibt es Kooperationen zur Isolation humaner Hepatozyten mit Dr. Jeanette Bierwolf (Viszeralchirurgie, UKB) sowie mit dem Aachener BMBF-geförderten Biobank-Programm.
Des Weiteren haben wir methodische Originalarbeiten zu Zellisolationstechniken, beispielsweise Sternzellen und Endothelzellen, erstellt, die als Referenz für die Teilprojekte dienen. In den vergangenen Jahren haben wir zur Erlernung der Methoden zahlreiche interne Trainingsprogramme für Studierende und Forscher/innen innerhalb des SFB/TRR57 angeboten sowie diverse nationale und internationale Gast-Wissenschaftler/innen in diesen Isolationstechniken geschult.
Publikationen
- Acharya P , Chouhan K., Weiskirchen S., Weiskirchen R. (2021): Cellular Mechanisms of Liver Fibrosis. frontiers in Pharmacology, 12, [5.330]
- Drescher H. K. , Schippers A., Rosenhain S., Gremse F., Bongiovanni L., de Bruin A., Eswaran S., Gallage S. U., Pfister D., Szydlowska M., Heikenwalder M., Weiskirchen S., Wagner N., Trautwein C., Weiskirchen R., Kroy D. C. (2020): L-Selectin/CD62L is a Key Driver of non-alcoholic Steatohepatitis in Mouse and Men. Cells, 9(5), 1106, [5.656]
- Azzam M. , El Safy S., Abdelgelil S. A., Weiskirchen R., Asimakopoulou A., de Lorenzi F., Lammers T., Mansour S., Tammam S. (2020): Targeting activated hepatic stellate cells using collagen-binding chitosan nanoparticles for siRNA delivery to fibrotic livers. Pharmaceutics, 12(6), 590, [4.773]
- Borkham-Kamphorst E. , Haas U., Van de Leur E., Trevanich A., Weiskirchen R. (2020): Chronic carbon tetra chloride applications induced hepatocyte apoptosis in Lipocaline 2 null mice through endoplasmic reticulum stress and unfolded protein response. International Journal of Molecular Sciences, 21(15), 5230, [4.183]
- Kim P. , Zhang C. C., Thoröe-Boveleth S., Weiskirchen S., Gaisa N. T., Buhl E. M., Stremmel W., Merle U., Weiskirchen R. (2020): Accurate Measurement of Copper Overload in an Experimental Model of Wilson Disease by Laser Ablation Inductively Coupled Plamsa Mass Spectrometry. Biomedicines, 8(9), 356, [3.600]
- Drescher H. K. , Bartsch L. M., Weiskirchen S., Weiskirchen R. (2020): Intrahepatic TH17/Treg cells in homeostasis and disease - it's all about balance. Front Pharmacol, 11, 588436, [3.845]
- Hermert D. , Martin I. V., Reiss L. K., Liu X., Breitkopf D. M., Reimer K. C., Alidousty C., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2020): The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis. Kidney International, 97(4), 741-752, [8.306]
- Weiskirchen S. , Weiper K., Tolba R. H., Weiskirchen R. (2020): All you can feed: Some comments on Production of mouse diets used in Biomedical Research with special emphasis on non-alcoholic fatty liver disease research. Nutrients, 12(1), 163,
- Yagmur E. , Otto S., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Decreased CTRP3 plasma concentrations are associated wtih sepsis and predict mortality in critically ill patients. Diagnostics, 9, 63, [2.489]
- Yagmur E. , Buergerhausen D., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Elevated CTRP1 plasma concentration is associated with sepsis and pre-existing type 2 diabetes mellitus in critically ill patients. J Clin Med, 8, 661, [5.583]
- Yagmur E. , Bast E., Mühlfeld A. S., Koch A., Weiskirchen R., Tacke F., Neulen J. (2019): High prevalence of sticky platelet syndrome in patients with infertility and pregnancy loss. J Clin Med, 8, 1328, [5.583]
- Weiskirchen S. , Kim P., Weiskirchen R. (2019): Laser ablation inductively coupled plasma spectrometry: metal imaging in experimental and clinical Wilson Disease. Inorganics, 7, 54, [1.900]
- Weiskirchen S. , Kim P., Weiskirchen R. (2019): Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma spectrometry. Annals Transl Med, 7(2), 72, [3.689]
- Weiskirchen R. , Weiskirchen S., Tacke F. (2019): Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications. Mol Aspects Med, 65, 2-15, [10.238]
- Weiskirchen R. , Weiskirchen S., Kim P., Winkler R. (2019): Software solutions for evaluation and visualization of laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI) data: a short overview. J Cheminform, 11, 16, [4.154]
- Weiskirchen R. , Tacke F. (2019): Pathophysiologie: Immunologie.“ Nichtalkoholische Fettleber. (Eds. Andreas Geier, Ali Canbay & Frank Lammert). Springer Verlag, im Druck, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic Fibrogenesis. Reference Module in Biomedical Sciences, , 1-7, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic fibrogenesis. Encyclopedia of Gastroenterology, 2nd Edition, Elsevier, New York, [0.200]
- Weiskirchen R. , Tacke F. (2019): Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease. Cells, 8, 16, [5.656]
- Weiskirchen R. , Stremmel W. (2019): Wilson disease: current knowledge, challenges and perspectives. Preface to the Focused Issue “Wilson’s disease: from genetics to management of disease (Eds. Ralf Weiskirchen & Wolfgang Stremmel). Annals Transl Med, 7(2), 55, [3.689]
- van Roeyen C. R. C. , Martin I. V., Drescher A., Schuett K. A., Hermert D., Raffetseder U., Otten S., Buhl E. M., Braun G., Kuppe C., Liehn E., Boor P., Weiskirchen R., Eriksson U., Gross O., Eitner F., Floege J., Ostendorf T. (2019): Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int, 95, 1103-1119, [8.000]
- Stremmel W. , Merle U., Weiskirchen R. (2019): Clinical features of Wilson disease. Annals Transl Med, 7(2), 61, [3.689]
- Stremmel W. , Staffer S. G., Weiskirchen R. (2019): Phosphatidylcholine passes by paracellular transport to the apical side of the polarized biliary tumor cell line Mz-ChA-1. Int J Mol Sci, 20, 4034, [4.183]
- Roderfeld M. , Padem S., Lichtenberger J., Quack T., Weiskirchen R., Longerich T., Schramm G., Churin Y., Irungbam K., Tschuschner A., Windhorst A., Grevelding C.G., Roeb E. (2019): Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes. Hepatology, 69, in press, [14.079]
- Pinheiro D. , Dias I., Silva K. R., Stumbo A. C., Thole A., Cortez E., de Carvalho L., Weiskirchen R., Carvalho S. (2019): Mechanisms underlying cell therapy in liver fibrosis: an overview. Cells, in press, [5.656]
- Mossanen J. C. , Kohlhepp M., Wehr A., Krenkel O., Liepelt A., Roeth A. A., Möckel D., Heymann F., Lammers T., Gassler N., Hermann J., Jankowski J., Neumann U. P., Luedde T., Trautwein C., Tacke F. (2019): CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence. Gastroenterology, 156(6), 1877-1889, [20.773]
- Meurer S.K. , Wimmer A.E., van de Leur E., Weiskirchen R. (2019): Endoglin trafficking/exosomal targeting in liver cells depends on N-glycosylation. Cells, 8, 997, [5.656]
- Mahli A. , Seitz T., Fresse K., Frank J., Weiskirchen R., Abdel-Tawab M., Behnam D., Hellerbrand C. (2019): Therapeutic application of micellar solubilized xanthohumol in a Western-type diet-induced mouse model of obesity, diabetes and non-alcoholic fatty liver disease. Cells, 8, 359, [5.656]
- Mahli A. , Seitz T., Beckröge T., Freese K., Thasler W.E., Benkert M., Dietrich P., Weiskirchen R., Bosserhoff A., Hellerbrand C. (2019): Bone morphogenetic protein-8B expression is induced in steatotic hepatocytes and promotes hepatic steatosis and inflammation in vitro. Cells, 8, 457, [5.656]
- Loosen S.H. , Koch A., Tacke F., Roderburg C., Luedde T. (2019): The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. Int J Mol Sci, 20(19), 4820, [4.183]
- Loosen S. H. , Lurje G., Wiltberger G., Vucur M., Koch A., Kather J. N., Paffenholz P., Tacke F., Ulmer F. T., Trautwein C. (2019): Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma. PLoS ONE, 14 (1), e0210944, [2.776]
- Loosen S. H. , Hoening P., Puethe N., Luedde M., Spehlmann M., Ulmer T. F., Cardenas D. V., Roy S., Tacke F., Trautwein C., Neumann U. P., Luedde T., Roderburg C. (2019): Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma. Sci Rep., 9(1), 1489, [4.011]
- Krenkel O. , Hundertmark J., Ritz T.P., Weiskirchen R., Tacke F. (2019): Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis. Cells, 8, 503, [5.656]
- Heymann F. , von Trotha K.-T., Preisinger C., Lynen-Jansen P., Roeth A. A., Geiger M., Geisler L. J., Frank A. K., Conze J., Luedde T., Trautwein C., Binnebösel M., Neumann U. P., Tacke F. (2019): Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation. JCI insight, [6.014]
- Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D.C., Drescher H.K. (2019): The inhibitory T cell receptors PD1 and 2B4 are differentially regulated on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis. Front Pharmacol, 10, 244, [3.845]
- Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D. C., Drescher H. K. (2019): The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis. frontiers in Pharmacology, [3.845]
- Gussen H. , Hohlstein P., Bartneck M., Warzecha K. T., Buendgens L., Luedde T., Trautwein C., Koch A., Tacke F. (2019): Neutrophils are a main source of circulating suPAR predicting outcome in critical illness. J Intensive Care, 7, 26, [3.510]
- Guillot A. , Tacke F. (2019): Liver Macrophages: Old Dogmas and New Insights. Hepatol Commun., 3 (6), 730-743, [0.800]
- Drescher H. K. , Weiskirchen R., Fülöp A., Hopf C., Gonzáles de San Roman E., Huesgen P.F., de Bruin A., Christ A., Tolba R., Trautwein C., Kroy D.C. (2019): The influence of different fat sources on steatohepatitis and fibrosis development in the Western diet mouse model of non-alcoholic steatohepatitis (NASH). Front Physiol, 10, 770, [3.394]
- Drescher H. K. , Weiskirchen S., Weiskirchen R. (2019): Current status in testing for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cells, 8, 845, [5.656]
- Borkham-Kamphorst E. , Van de Leur E., Haas U., Weiskirchen R. (2019): Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response. Cell Signal, 55, 90-99, [3.388]
- Bartneck M. , Schrammen P. L., Möckel D., Govaere O., Liepelt A., Krenkel O., Ergen C., McCain M. V., Eulberg D., Luedde T., Trautwein C., Kiessling F., Reeves H., Lammers T., Tacke F. (2019): The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers. Cell Mol Gastroenterol Hepatol, 7(2), 371-390, [6.850]
- Asimakopoulou A. , Vucur M., Luedde T., Weiss T.S., Schneiders S., Kalampoka S., Weiskirchen R. (2019): Perilipin 5 and Lipocalin 2 expression in hepatocellular carcinoma. Cancers, 11(3), 385, [6.162]
- Yagmur E. , Buendgens L., Herbers U., Beeretz A., Weiskirchen R., Koek G. H., Trautwein C., Tacke F., Koch A. (2018): High mobility group box 1 as a biomarker in critically ill patients. J Clin Lab Anal, 32(8), e22584, [1.728]
- Weiskirchen S. , Weiskirchen R. (2018): A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS. Atlas of Science, December, [0.200]
- Weiskirchen R. , Tacke F. (2018): The role of radiologic modalities in diagnosing non-alcoholic steatohepatitis (NASH) and fibrosis. Curr Hepat Rep, 17, 324-335, [0.200]
- Warzecha K. T. , Bartneck M., Möckel D., Appold L., Ergen C., Al Rawashdeh W., Gremse F., Niemietz P. M., Jahnen‐Dechent W., Trautwein C., Kiessling F., Lammers T., Tacke F. (2018): Targeting and Modulation of Liver Myeloid Immune Cells by Hard-Shell Microbubbles. Adv Biosyst, 2(5), 1-24, [2.855]
- Vucur M. , Roderburg C., Kaiser L., Schneider A. T., Roy S., Loosen S. H., Luedde M., Trautwein C., Koch A., Tacke F., Luedde T. (2018): Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Dis Markers, , 1983421, [2.761]
- Ullmann P. , Rodriguez F., Schmitz M., Meurer S. K., Qureshi-Baig K., Felten P., Ginolhac A., Antunes L., Frasquilho S., Zügel N., Weiskirchen R., Haan S., Letellier E. (2018): The microRNA-371~373 cluster represses colon cancer initiation and metastatc colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Res, 78, 3793-3808, [8.378]
- Tacke F. , Weiskirchen R. (2018): An update on the recent advances in antifibrotic therapies. Exp Rev Gastroenterol Hepatol, 12(11), 1143-1152, [2.991]
- Sonntag R. , Giebeler N., Nevzorova Y. A., Bangen J. M., Fahrenkamp D., Lambertz D., Haas U., Hu W., Gassler N., Cubero F. J., Müller-Newen G., Abdallah A. T., Weiskirchen R., Ticconi F., Costa I. G., Barbacid M., Trautwein C., Liedtke C. (2018): Cyclin E1 and Cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. Proc Natl Acad Sci USA, 115, 9282-9287, [9.580]
- Schröder S. K. , Asimakopoulou A., Weiskirchen R. (2018): Lipocalin 2 as a potential diagnostic and/or prognostic biomarker in prostate, lung and liver cancer. Clinics of Oncology, 1(3), 1-16, [0.200]
- Puengel T. , Tacke F. (2018): Repair macrophages in acute liver failure. Gut, 67(2), 202-203, [17.160]
- Pombeiro I. , Loosen S. H, Roy S., Schueller F., Niewenhuisen L., Luedde M., Vucur M., Tacke F., Binnebösel M., Schoening W., Trautwein C., Luedde T., Neumann U. P., Roderburg C. (2018): Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer. J Clin Med, 7(7), 175, [5.583]
- Moellmann J. , Klinkhammer B. M., Onstein J., Stöhr R., Jankowski V., Jankowski J., Lebherz C., Tacke F., Marx N., Boor P., Lehrke M. (2018): Glucagon-like peptide-1 and its cleavage products are renoprotective in murine diabetic nephropathy. Diabetes, 67(11), 2410-2419, [7.199]
- Luedde M. , Spehlmann M. E., Hippe H.-J., Loosen S. H., Roy S., Cardenas D. V., Vucur M., Frey N., Koch A., Luedde T., Trautwein C., Tacke F., Roderburg C. (2018): Serum levels of kisspeptin are elevated in critically ill patients. PLoS ONE, 13(10), e0206064, [2.776]
- Loosen S. H. , Tacke F., Binnebosel M., Leyh C., Vucur M., Heitkamp F., Schoening W., Ulmer T. F., Alizai P. H., Trautwein C., Koch A., Longerich T., Roderburg C., Neumann U. P., Luedde T. (2018): Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases. Oncotarget, 9(43), 27027-27038, [5.168]
- Loosen S. H. , Schulze-Hagen M., Leyh C., Benz F., Vucur M., Kuhl C., Trautwein C., Tacke F., Bruners P., Roderburg C., Luedde T. (2018): IL-6 and IL-8 Serum Levels Predict Tumor Response and Overall Survival after TACE for Primary and Secondary Hepatic Malignancies. Int J Mol Sci, 19(6), 1766, [4.183]
- Koch A. , Yagmur E., Linka J., Schumacher F., Bruensing J., Buendgens L., Herbers U., Koek G. H., Weiskirchen R., Trautwein C., Tacke F. (2018): High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients. Dis Markers, 8583121, [2.761]
- Koch A. , Yagmur E., Hoss A., Buendgens L., Herbers U., Weiskirchen R., Koek G. H., Trautwein C., Tacke F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J Clin Lab Anal, , e22614, [1.728]
- Koch A. , Weiskirchen R., Krusch A., Bruensing J., Buendgens L., Herbers U., Yagmur E., Koek G. H., Trautwein C., Tacke F. (2018): Visfatin serum levels predict mortality in critically ill patients. Dis Markers, 7315356, [2.761]
- Kim P. , Weiskirchen S., Uerlings R., Kueppers A., Stellmacher F., Viveiros A., Zoller H., Weiskirchen R. (2018): Quantification of liver iron overload disease with laser ablation inductively coupled plasma mass spectrometry. BMC Med Imaging, 18, 51, [1.622]
- Gauthier A. , Fisch A., Seuwen K., Baumgarten B., Ruffner H., Aebi A., Rausch M., Bartneck M., Weiskirchen R., Tacke F., Storm G., Lammers T., Ludwig M.-G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials, 178, 481-495, [10.273]
- Borkham-Kamphorst E. , Steffen B. T., van de Leur E., Haas U., Weiskirchen R. (2018): Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis. Cell Signal, 51, 72-85, [3.388]
- Meurer, S. K. , Weiskirchen, R. (2018): Activation by Inhibition. Atlas of Science,
- Uerlings, R. , Moreno D., Murillo, O., Gazquez, C., Hernandez-Alcoceba, R., Gonzalez-Aseguinolaza, G., Weiskirchen, R. (2018): Brain copper storage after long-term correction of Wilson's disease in a murine model of gene therapy. Neurol. Genet., 4, e243,
- Koch, A. , Yagmur, E., Hoss, A., Buendgens, L., Herbers, U., Weiskirchen, R., Koek, G. H., Trautwein, C., Tacke, F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J. Clin. Lab. Anal., in press., doi: 10.1002/jcla.22614,
- Yagmur, E. , Koch, A., Weiskirchen, R. Trautwein, C., Tacke, F. (2018): Clinical relevance of elevated high-mobility group box 1 (HMGB1) in critically ill patients. J. Clin. Lab. Anal., 33, e22614,
- Gauthier, A. , Fisch, A., Seuwen, K., Baumgarten, B., Ruffner, H., Aebi, A., Rausch, M., Bartneck, M., Weiskirchen, R., Tacke, F., Storm, G., Lammers, T., Ludwig, M. G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolutive phenotype in human primary macrophages to support healing of chronic wounds. Biomaterials, 04.006, in press,
- Koch, A. , Yagmur, E., Linka, J., Schumacher, F., Bruensing, J., Buendgens, L., Herbers, U., Koek, G. H., Weiskirchen, R., Trautwein, C., Tacke, F. (2018): High circulating caspase-cleaved keratin 18 fragments (M30) indicate short-term mortality in critically ill patients. Dis. Markers, 2018, 8583121,
- Schröder, S. K. , Asimakopoulou, A., Weiskirchen, R. (2018): Lipocalin 2 as a potential diagnostic and/or prognostic biomarker in prostate, lung and liver cancer. Clinics of Oncol., in press,
- Borkham-Kamphorst, E. , Van de Leur, E., Buhl, E. M., Meurer, S. K., Weiskirchen, R. (2018): N-glycosylation of Lipocalin 2 is not required for secretion or exosome targeting.. Front. Pharmacol., 9:426,
- Weiskirchen, R. , Weiskirchen, S., Tacke, F. (2018): Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications. Mol Aspects Med., , in press. doi: 10.1016/j.mam.2018.06.003,
- Weiskirchen, R. , Weiskirchen, S., Tacke, F. (2018): Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts. F1000, Res. 7, 921,
- Jenkitkasemwong, S. , Akinyode, N., Paulus, E., Weiskirchen, R., Hojyo, S., Fukada, T., Giraldo, G., Schrier, J., Garcia, A., Janus, C., Giasson, B., Knutson, M. D. (2018): SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc. Natl. Acad. Sci. U S A, 115, E1769-E1778,
- Lenk, L. , Pein, M., Will, O., Gomez, B., Viol, F., Hauser, C., Egberts, J.-H., Gundlach, P., Tiwari, S., Weiskirchen, R., Rose-John, S., Röcken, C., Mikulits, W., Wenzeli, P., Schneider, G., Saur, D., Schäfer, H., Sebens, S. (2018): The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. OncoImmunology, 7, e1368603,
- Ullmann, P. , Rodriguez, F., Schmitz, M., Meurer, S. K., Qureshi-Baig, K., Felten, P., Ginolhac, A., Antunes, L., Frasquilho, S., Zügel, N. Weiskirchen, R., Haan, S., Letellier, E. (2018): The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Res., in press,
- Krenkel, O. , Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., Weiskirchen, R., Longerich, T., Costa, I. G., Anstee, Q. M., Trautwein, C., Tacke, F. (2018): Therapeutic inhibition of inflammatory monocytes reduces steatohepatitis and liver fibrosis. Hepatology, 67, 1270-1283,
- Weiskirchen, S. , Weiskirchen, R. (2018): Ultrapure cells for liver research. Atlas of Science, May 30, 2018,
- Meurer, S. K. , Weiskirchen, R. (2018): Usage of Mitogen-Activated Protein Kinase small molecule inhibitors: more than just inhibition!. Front. Pharmacol., 9:98,
- Moreno, D. , Murillo, O., Gazquez, C., Hernandez-Alcoceba, R., Uerlings, R., Gonzalez-Aseguinolaza, G., Weiskirchen, R. (2018): Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry. J. Hepatol., 68, 199-201,
- Alsamman, M. , Sterzer, V., Meurer, S. K., Sahin, H., Schaeper, U., Kuscuoglu, D., Strnad, P., Weiskirchen, R., Trautwein, C., Scholten, D. (2018): Endoglin in human liver disease and murine models of liver fibrosis – a protective factor against liver fibrosis. Liver International, 38, 858-867, [4.470]
- Vucur, M. , Roderburg, C., Kaiser, L., Schneider, A.T., Roy, S., Loosen, S., Luedde, M., Trautwein, C., Koch, A., Tacke, F., Luedde, T. (2017): Elevated serum levels of the mixed lineage kinase domain-like protein (MLKL) predict survival of patients during intensive care unit treatment. Hindawi, [2.348]
- Loosen, S.H. , Roderburg, C., Kauertz, K.L., Koch, A., Vucur, M., Schneider, A.T., Binnebösel, M., Ulmer, T.F., Lurje, G., Schoening, W., Tacke, F., Trautwein, C., Longerich, T., Dejong, C.H., Neumann, U.P., Luedde, T. (2017): CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma. Scientific Reports, 7, [5.228]
- Lambertz, J. , Berger, T., Mak, T.W., van Helden, J., Weiskirchen, R. (2017): Lipocalin-2 in Fructose-Induced Fatty Liver Disease. frontiers in Physiology, [4.031]
- Hao, F. , Cubero, F.J., Ramadori, P., Liao, L., Haas, U., Lambertz, D., Sonntag, R., Bangen, J.M., Gassler, N., Hoss, M., Streetz, K.L., Reissing, J., Zimmermann, H.W., Trautwein, C., Liedtke, C., Nevzorova, Y.A. (2017): Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice. Cell Death & Disease, 8 (10), [5.378]
- Bangen, J.M. , Hammerich, L., Sonntag, R., Baues, M., Haas, U., Lambertz, D., Longerich, T., Lammers, T., Tacke, F., Trautwein, C., Liedtke C. (2017): Targeting CCl4 -induced liver fibrosis by RNA interference-mediated inhibition of cyclin E1 in mice. Hepatology, 66 (4), 1242-1257, [13.246]
- Puengel, T. , Krenkel, O., Kohlhepp, M., Lefebvre, E., Luedde, T., Trautwein, C., Tacke, F. (2017): Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury. PLoS One, [3.057]
- Buendgens, L. , Yagmur, E., Bruensing, J., Herbers, U., Baeck, C., Trautwein, C., Koch, A., Tacke, F. (2017): Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Disease Markers, 18, [2.348]
- Weiskirchen, S. , Weiskirchen R. (2017): Resveratrol: Is It Really Good for Liver Health?. Hepatitis Monthly, 17 (8), [1.932]
- Weiskirchen S. , Tag C.G., Sauer-Lehnen S., Tacke F., Weiskirchen R. (2017): Isolation and culture of primary murine hepatic stellate cells. Methods in Molecular Biology, 1627, 165-191, [1.170]
- Asimakopoulou A. , Borkham-Kamphorst E., Van de Leur E., Weiskirchen R. (2017): Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis. Data in Brief, August;13, 644-649, [0.200]
- Asimakopoulou A , Fülöp A., Borkham-Kamphorst E., de Leur E.V., Gassler N., Berger T., Beine B., Meyer H.E., Mak T.W., Hopf C., Henkel C., Weiskirchen R. (2017): "Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis.". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, (17) 30118-7, [5.158]
- Bábíčková J. , Klinkhammer B.M., Buhl E.M., Djudjaj S., Hoss M., Heymann F., Tacke F., Floege J., Becker J.U., Boor P. (2017): Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney International, 91(1), 70-85, [7.683]
- Dietzel E. , Weiskirchen S., Floehr J., Horiguchi M., Todorovic V., Rifkin D.B., Jahnen-Dechent W., Weiskirchen R. (2017): Latent TGF-β binding protein-1 deficiency decreases female fertility. Biochemical and Biophysical Research Communications, 482(4), 1387-1392, [2.371]
- Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F (2017): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44, [2.053]
- Meurer S.K. , Weiskirchen R. (2017): Endoglin (ENG). Encyclopedia of Signaling Molecules, 2nd Edition 2017 ISBN: 978-1-4419-0460-7, [0.200]
- Mossanen, J. , Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., Luedde, T., Marx, G., Strassburg, C., Roskams, T., Trautwein, C., Tacke, F. (2017): CCR2+ monocytes aggravate the early phase of acetaminophen induced acute liver injury. Journal of Hepathology, 64(5), 1667–1682, [10.590]
- Schneider, A. , Gautheron, J., Feoktistova, M., Roderburg, C., Loosen, S. H., Roy, S., Benz, F., Schemmer, P., Büchler, M. W., Nachbur, U., Neumann, U. P., Tolba, R., Luedde, M., Zucman-Rossi, J., Panayotova-Dimitrova, D., Leverkus, M., Preisinger, C., Tacke, F., Trautwein, C., Longerich, T., Vucur, M., Luedde, T. (2017): RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell, 31 (1), 94–109, [23.214]
- Uerlings, R. , Weiskirchen, R. (2017): An At-A-Glance Visualizatioon of Regional Metal Accretion in Tissue Samples via Image Overlay in Laser Ablation Inductively Coupled Plasma Mass Spectrometry. Laser Ablation: Advances in Research an Applications, Nova Science Publishers, 3, ISBN: 978-1-53612-408-8, [0.200]
- Weiskirchen R. (2017): Fast progression of liver damage in lysosomal acid lipase deficiency. Current Medical Research and Opinion, [2.643]
- Weiskirchen R. , Tacke F. (2017): Interleukin-33 in the pathogenesis of liver fibrosis: alarming ILC2 and hepatic stellate cells. Cellular & Molecular Immunology, 14 (2), 143-145, [5.193]
- Weiskirchen, R. (2016): Intratumor heterogeneity, variability and plasticity: Questioning the current concepts in classification and treatment of hepatocellular carcinoma.. Hepatobiliary Surg Nutr, 5, 183-187, [3.050]
- Weiskirchen, R. (2016): Hepatoprotective and anti-fibrotic agents: It’s time to take the next step.. Frontiers in Pharmacology, 6, 303, [4.418]
- van Helden, J. , Weiskirchen, R. (2016): Diagnostischer Wert der quantitativen HBsAg Bestimmung bei der Hepatitis B Infektion (Diagnostic value of the quantitative HBsAg determination in hepatitis B infections).. Zeitschrift für Gastroenterologie, 54, 319-326, [1.357]
- Susnea, I. , Weiskirchen, R. (2016): Trace metal imaging in diagnostic of hepatic metal disease.. Mass Spectrometry Reviews, 35 (6), 666-686, [9.346]
- Uerlings, R , Matusch, A., Weiskirchen, R. (2016): Reconstruction of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) spatial distribution images in Microsoft Excel 2007.. Int J Mass Spectrom, 395, 27-35, [1.183]
- Buhl, E. M. , Djudjaj, S., Babickova, J., Klinkhammer, B. M., Folestad, E., Borkham-Kamphorst, E., Weiskirchen, R., Hudkins, K., Alpers, C. E., Eriksson, U., Floege, J., Boor, P. (2016): Role of PDGF-D in healthy and fibrotic kidneys.. Kidney Int, 89, 848-861, [7.683]
- Borkham-Kamphorst, , Weiskirchen, R. (2016): The PDGF system and its antagonists in liver fibrosis.. Cytokine Growth Factor Rev, 28C, 53-61, [6.571]
- Borkham-Kamphorst, E. , Steffen, B. T., van de Leur, E., Haas, U., Tihaa, L., Friedman, S. L., Weiskirchen, R. (2016): CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.. Cell Signal, 28, 34-42, [4.191]
- Weiskirchen, R. , Tacke, F. (2016): Neue Therapieoptionen für die Leberfibrose: Aus der Forschung in die Klinik. New treatment options for liver fibrosis: From-bench-to-bedside.. Der Gastroenterologe, 11, 40-46, [0.200]
- Asimakopoulou, A. , Borkham-Kamphorst, E., Tacke, F., Weiskirchen, R. (2016): Lipocalin-2 (NGAL/LCN2), a "HELP-ME" signal in organ inflammation.. Hepatology, 63, 669-671, [11.711]
- Weiskirchen, R. , Tacke, F. (2016): Liver fibrosis: from pathogenesis to novel therapies.. Digestive Diseases and Sciences, 34, 410-422, [2.516]
- Meurer S.K. , Neß M, Weiskirchen S, Kim P, Tag CG, Kauffmann M, Huber M, Weiskirchen R. (2016): Isolation of mature (peritoneum-derived) mast cells and immature (bone marrow-derived) mast cell precursors from mice. PLoS One, 11(6), e0158104, [3.057]
- Merle U. , Weiskirchen R. (2016): Wilson's disease: An inherited, silent, copper intoxication disease. Eur Med J. Neurol., 4:, 74-83, [1.920]
- Weiskirchen S. , Weiskirchen R. (2016): Resveratrol: How much wine do you have to drink to stay healthy?. Advances in Nutrition, 7, 706-718, [5.201]
- Weiskirchen R. , Tacke F. (2016): Leberfibrose: von der Pathologie zu den Therapiemöglichkeiten. Falk Gastro-Kolleg., , 1-11, [0.200]
- Weiskirchen R. , Tacke F. (2016): Liver fibrosis – which mechanisms matter?. Clinical Liver Disease, 8 (4), 94-99, [0.360]
- Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F. (2016): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44,
- Schon H.T. , Bartneck M., Borkham-Kamphorst E., Nattermann J., Lammers T., Tacke F., Weiskirchen R. (2016): Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis. Frontiers in Pharmacology, 7, 33, [4.418]
- Koppe C. , Verheuged P., Gautheron J., Reisinger F., Kreggenwinkel K., Roderburg C., Quagliata L., Terracciano L., Gassler N., Tolba R., Boege Y., Weber A., Karin M., Luedde M., Neumann U. P., Weiskirchen R., Tacke F., Vucur M., Trautwein C., Lüscher B., Preisinger C., Heikenwälder M., Lüdde T. (2016): IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylation the cell death mediator RIPK1. Hepatology, 64 (4), 1217-1231, [11.711]
- Borkham-Kamphorst E. , Steffen B. T., Van de Leur E., Tihaa L., Haas U., Weiskirchen R. (2016): Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response. BBA Mol Cell Res., 1863, 2604-2612, [5.128]
- Kanta J. , Mrkvicová A., Weiskirchen R. (2016): Editorial: Liver myofibroblasts. Frontiers in Physiology, 7, 343, [4.031]
- Schon H.-T. , Weiskirchen R. (2016): Exercise-induced release of pharmacologically active substances and their relevance for therapy of hepatic injury. Frontiers in Pharmacology, 7, 283, [4.418]
- Wallace, M. C., , Hamesch, K., Lunova, M., Kim, Y., Weiskirchen, R., Strnad, P., Friedman, S. L. (2015): Standard Operating Procedures in experimental liver research: Thioacetamide model in mice. Laboratory Animals, 49(1), 59-69, [1.120]
- Tolba, R. H. , Riediger, B. M., Weiskirchen, R. (2015): Standard Operating Procedures in experimental liver research: time to achieve uniformity. Lab Animals, 49(S1), 21-29, [1.553]
- van Helden, J. , Weiskirchen, R. (2015): Experience with the first fully automated chemiluminescence immunoassay for the quantification of 1α, 25-Dihydroxy-Vitamin D. Clin Chem Lab Med, 53, 761-770, [3.017]
- Tolba, R. H. , Kraus, T., Liedtke, C., Schwarz, M., Weiskirchen, R. (2015): Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice.. Laboratory Animals, 49(1), 59-69, [1.553]
- Hamesch, K. , Borkham-Kamphorst, E., Strnad, P., Weiskirchen, R. (2015): Lipopolysaccharide-induced inflammatory liver injury in mice.. Lab Anim, 49(S1), 37-46, [1.120]
- Borkham-Kamphorst, E. , Meurer, S. K., Van de Leur, E., Haas, U., Tihaa, L., Weiskirchen, R. (2015): PDGF-D signalling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β.. Cell Signal, 27, 1305-1314, [4.320]
- Borkham-Kamphorst, E. , Alexi, P., Tihaa, L., Haas, U., Weiskirchen, R. (2015): Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.. Biochem Biophys Res, Commun 457, 307-313, [2.300]
- Boaru, S. G. , Borkham-Kamphorst, E., Van de Leur, E., Lehnen, E., Liedtke, C., Weiskirchen, R. (2015): NLRP3 inflammasome expression is driven by NF-kB in cultured hepatocytes.. Biochem Biophys Res Commun, 458, 700-706, [2.300]
- Boaru, S. G. , Merle, U., Uerlings, R., Zimmermann, A., Willheim, C., Ferenci, P., Stremmel, W., Weiskirchen, R. (2015): Laser ablation inductively coupled plasma mass spectrometry imaging of metals in experimental and clinical Wilson's disease.. J Cell Mol Med, 19, 806-814, [4.010]
- Asimakopoulou, A. (2015): Lipocalin 2 in the pathogenesis of fatty liver disease and non-alcoholic steatohepatitis.. Clin. Lipidol, 10, 47-67, [0.870]
- Uerlings, R. , Weiskirchen, R. (2015): Laser ablation inductively coupled plasma mass spectrometry in biomedicine and clinical diagnosis.. Cellular & Molecular Medicine, open access 1, 1:-1, [5.193]
- Weiskirchen, R. , Tacke, F. (2015): Small heterodimer partner (SHP) links hepatitis C and liver fibrosis: a small protein on the big stage. Liver Int, 35, 2218-2221, [4.470]
- Tag, C. G , Sauer-Lehnen, S., Weiskirchen, S., Borkham-Kamphorst, E., Tolba, R. H., Tacke, F., Weiskirchen, R. (2015): Bile duct ligation in mice: Induction of inflammatory liver injury and fibrosis by obstructive cholestasis.. Journal of Visualized Experiments, 96, e52438, [1.240]
- Tag, C. G. , Weiskirchen, S. K., Hittatiya, K., Tacke, F., Tolba, R. H., Weiskirchen, R. (2015): Induction of experimental obstructive cholestasis in mice.. Laboratory Animals, 49(1), 70-80, [1.553]
- Heymann, F. , Hamesch, K., Weiskirchen, R., Tacke, F. (2015): The Concanavalin A model of acute hepatitis in mice.. Lab Anim, 49(S1), 12-20., [1.120]
- Berres, M. L. , Asmacher, S. S., Lehmann, J., Jansen, C., Görtzen, J., Klein, S., Meyer, C., Strunk, H. M., Fimmers, R., Tacke, F., Strassburg, C. P., Trautwein, C., Sauerbruch, T., Wasmuth, H. E., Trebicka (2015): CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt.. J Hepatol, 62(2), 332-339, [11.370]
- Bartneck, M. , Warzecha, K. T., Tag, C. G., Sauer-Lehnen, S., Heymann, F., Trautwein, C., Weiskirchen, R., Tacke, F. (2015): Isolation and time lapse microscopy of highly pure hepatic stellate cells.. Anal Cell Pathol (Amst), Article ID-417023, [0.850]
- Bartneck, M. , Topuz, F., Tag, C. G., Sauer-Lehnen, S., Warzecha, C. T., Trautwein, C., Weiskirchen, R., Tacke, F. (2015): Molecular response of liver sinusoidal endothelial cells on hydrogels. Mater Sci Eng C Mater Biol, Appl 51, 64-72, [3.420]
- Winkler, S. , Borkham-Kamphorst, E., Stock, P., Brückner, S., Weiskirchen, R., Christ, B. (2014): Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model.. Experimental Cell Research, 326 (2), 230-239, [3.930]
- van Helden , J. , Weiskirchen, R (2014): Hepatitis C diagnostics: clinical evaluation of the HCV-core antigen determination (Hepatitis C Diagnostik: Klinische Evaluierung der HCV-core Antigen Bestimmung). Zeitschrift für Gastroenterologie, 52(10), 1164-1170, [1.357]
- Schon, H. T , Weiskirchen, R. (2014): Immunmodulatory effects of transforming growth factor-β in the liver.. Hepatobiliary Surgery and Nutrition, 3, 386-406, [3.050]
- Meurer, S. K. , Alsamman, M., Scholten, D., Weiskirchen, R. (2014): Endoglin in liver fibrogenesis – Bridging basic science and clinical practice.. World J. Biol Chem, 5(2), 180-203,
- Martinez-Palacian, A. , Martinez-Palacian, A., Kanse, S. M., Weiskirchen, R. (2014): Factor VII activating protease (FSAP): A novel protective factor in liver fibrosis. Proteomics Clinical Applications, 8(5-6), 438-446, [2.959]
- Bultmann, C. A. , Weiskirchen, R. (2014): MAKERGAUL: An innovative MAK-based model and software for real-time PCR quantification.. Clin Biochem, 47(1-2), 117-122, [2.382]
- Borkham-Kamphorst E. , Schaffrath, C., van de Leur, E., Haas, U., Tihaa, L., Meurer, S. K., Nevzorova, Y. A., Liedtke, C., Weiskirchen, R. (2014): The anti-fibrotic effects of ccn1/cyr61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated tgf-beta signaling.. Biochim Biophys Acta, 1843(5), 902-914, [5.128]
- Boaru, S. G. , Merle, U., Uerlings, R., Zimmermann, A., Weiskirchen, S., Stremmel, W., Weiskirchen, R. (2014): Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometry.. BMC Neuroscience, , 15-98., [2.304]
- Asimakopoulou, A. , Borkham-Kamphorst, E., Henning, M., Yagmur, E., Gassler, N., Berger, T., Mak, T. W., Weiskirchen, R. (2014): Lipocalin 2 (LCN2) regulates OXPAT expression and intracellular lipid droplet formation in the liver.. BBA Mol Cell Biol Lipids, 1841 (10), 1513-1524, [4.779]
- Abnaof, K. , Mallela, N., Vinoid, N., Walenda, G., Meurer, S. K., Seré, K., Lin, Q., Smeets, B., Hoffmann, K., Wagner, W., Zenke, M., Weiskirchen, R., Fröhlich, H. (2014): TGF-beta stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Systems Biol, 8, 55, [2.208]
- Weiskirchen, R. , Tacke, F. (2014): Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology.. Hepatobiliary Surgery and Nutrition, 3 (6), 344-363, [3.050]
- Tacke, F. , Zimmermann, H. W. (2014): Macrophage heterogeneity in liver injury and fibrosis.. Journal of Hepatology, 60(5), 1090-1096, [10.590]
- Tacke, F. , Weiskirchen, R. (2014): Liver immunology: new perspectives. Hepatobiliary Surg Nutr, 3 (6), 330, [3.050]
- Tacke, F. , Roderburg, C., Benz, F., Cardenas, D. V., Luedde, M., Hippe, H. J., Frey, N., Vucur, M., Gautheron, J., Koch, A., Trautwein, C., Luedde, T. (2014): Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients.. Critocal Care Medicine, 42(5), 1096-1104, [7.422]
- Tacke, F. , Galm, O., Kanig, N., Yagmur, E., Brandt, S., Lindquist, J. A., Eberhardt, C. S., Raffetseder, U., Mertens, P. R. (2014): High prevalence of Y-box protein-1/p18 fragment in plasma of patients with malignancies of different origin.. BMC Cancer, 14, 33, [3.265]
- Hammerich, L. , Bangen, J. M., Govaere, O., Zimmermann, H. W., Gassler, N., Huss, S., Liedtke, C., Prinz, I., Lira, S. A., Luedde, T., Roskams, T., Trautwein, C., Heymann, F., Tacke, F. (2014): Chemokine receptor ccr6-dependent accumulation of gammadelta t cells in injured liver restricts hepatic inflammation and fibrosis.. Hepatology, 59(2), 630-642, [11.711]
- Koch, A. , Zimmermann, H. W., Gassler, N., Jochum, C., Weiskirchen, R., Bruensing, J., Buendgens, L., Dückers, H., Bruns, T., Gerken, G., Neumann, U. P., Adams, D. H., Trautwein, C., Canbay, A., Tacke, F. (2014): Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure.. Liver International, 34(9), 13301339, [4.470]
- Ehling, J. , Bartneck, M., Wie, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., Kiessling, F., Trautwein, C., Lammers, T., Tacke, F. (2014): CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.. Gut, 63(12), 1960-71, [14.921]
- Buendgens, L. , Bruensing, J., Matthes, M., Dückers, H., Luedde, T., Trautwein, C., Tacke, F., Koch, A. (2014): Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea. Journal of Critical Care, 29(4), 696, [2.445]
- Bartneck, M. , Peters, F. M., Warzecha, K. T., Bienert, M., van Bloois, L., Trautwein, C., Lammers, T., Tacke, F. (2014): Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages.. Nanomedicine, 10(6), 1209-1220, [5.671]
- Wehr, A. (2014): Pharmacological Inhibition of the Chemokine CXCL16 Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury.. PLoS One, 9 (11), [3.050]
- Baeck, C. , Wie, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., Tacke, F. (2014): Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice.. Hepatology, 59(3), 1060-1072, [11.711]
- Weiskirchen, R. , Meurer, S. K. (2013): BMP-7 counteracting TGF-beta1 activities in organ fibrosis. Frontiers in Bioscience (Landmark Ed), 18, 1407-1434, [2.484]
- Weiskirchen, R. , Weimer, J., Meurer, S. K., Kron, A., Seipel, B., Vater, I., Arnold, N., Siebert, R., Xu, L., Friedman, S. L., Bergmann, C. (2013): Genetic characteristics of the human hepatic stellate cell line LX-2.. PLoS One, 8 (10), [3.057]
- Sahin, H. , Borkham-Kamphorst, E., do, O. N., Berres, M. L., Kaldenbach, M., Schmitz, P., Weiskirchen, R., Liedtke, C., Streetz, K. L., Maedler, K., Trautwein, C., Wasmuth, H. E. (2013): Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.. Hepatology, 57 (2), 797-805, [11.711]
- M-M, P. , Weiskirchen, R., Gassler, N., Bosserhoff, A. K., Becker, J. S. (2013): Novel bioimaging techniques of metals by laser ablation inductively coupled plasma mass spectrometry for diagnosis of fibrotic and cirrhotic liver disorders.. PLoS One, 8 (3), [3.057]
- Meurer, S. K. , Alsamman, M., Sahin, H., Wasmuth, H. E., Kisseleva, T., Brenner, D. A., Trautwein, C., Weiskirchen, R., Scholten, D. (2013): Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line.. PLoS One, 8 (2), [3.057]
- Martin, I. V. , Borkham-Kamphorst E, Zok S, van Roeyen CRC, Eriksson U, Boor P, Hiththetiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T. (2013): Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis. The American Journal of Pathology, 182 (1), 107-117, [4.206]
- Labbus, K. , Henning, M., Borkham-Kamphorst, E., Geisler, C., Berger, T., Mak, T. W., Knuchel, R., Meyer, H. E., Weiskirchen, R., Henkel, C. (2013): Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions.. Journal of Proteomics, 78, 188-196, [3.867]
- Koch, A. , Weiskirchen, R., Kunze, J., Duckers, H., Bruensing, J., Buendgens, L., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.. Journal Critical Care, 28 (6), 947-953, [2.445]
- Huss, S. , Stellmacher, C., Goltz, D., Khlistunova, I., Adam, A. C., Trebicka, J., Kirfel, J., Buttner, R., Weiskirchen, R. (2013): Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice.. BMC Gastroenterology, 13, 8, [2.101]
- Cubero, F. J. , Singh, A., Borkham-Kamphorst, E., Nevzorova, Y. A., Al Masaoudi, M., Haas, U., Boekschoten, M. V., Gassler, N., Weiskirchen, R., Muller, M., Liedtke, C., Trautwein, C. (2013): Tnfr1 determines progression of chronic liver injury in the ikkgamma/nemo genetic model.. Cell Death & Differentiation, 20 (11), 1580-1592, [8.218]
- Borkham-Kamphorst, E. , Zimmermann, H. W., Gassler, N., Bissels, U., Bosio, A., Tacke, F., Weiskirchen, R., Kanse, S. M. (2013): Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.. Journal of Hepatology, 58 (1), 104-111, [10.590]
- Borkham-Kamphorst, E. , van de Leur, E., Zimmermann, H.W., Karlmark, K.R., Tihaa, L., Haas, U., Tacke, F., Berger, T., Mak, T.W., Weiskirchen, R., (2013): Protective effects of Lipocalin-2 (LCN2) in acute and chronic liver injury suggesting a novel function in liver homeostasis.. BBA Molecular Basis of Disease, 1832 (5), 660-73, [5.128]
- Wehr, A. , Baeck, C., Heymann, F., Niemietz, P. M., Hammerich, L., Martin, C., Zimmermann, H. W., Pack, O., Gassler, N., Hittatiya, K., Ludwig, A., Luedde, T., Trautwein, C., Tacke, F. (2013): Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis.. The Journal of Immunology, 190 (10), 5226-5236, [4.179]
- Zimmermann H. W. , Mueller, J. R., Seidler, S., Luedde, T., Trautwein, C., Tacke, F. (2013): Frequency and Phenotype of Human Circulating and Intrahepatic Natural Killer Cell Subsets Is Differentially Regulated according to Stage of Chronic Liver Disease.. Digestion, 88 (1), 1-16, [1.884]
- Roderburg, C. , Luedde, M., Vargas Cardenas, D., Vucur, M., Mollnow, T., Zimmermann, H. W., Koch, A., Hellerbrand, C., Weiskirchen, R., Frey, N., Tacke, F., Trautwein, C., Luedde, T. (2013): miR-133a mediates TGF-ß-dependant derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. Journal of Hepatology, 58 (4), 736-742, [10.590]
- Nevzorova, Y. A. , Hu, W., Cubero, F. J., Haas, U., Freimuth, J., Tacke, F., Trautwein, C., Liedtke, C. (2013): Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis.. Biochimica et Biophysica Acta, 1832(10), 1765-75, [5.158]
- Koch, A. , Buendgens, L., Dückers, H., Bruensing, J., Matthes, M., Kunze, J., Lutz, H. H., Luedde, T., Tischendorf, J. J. W., Trautwein, C., Tacke, F. (2013): Ursachen, patientenspezifische Risikofaktoren und prognostische Indikatoren bei akuter gastrointestinaler Blutung und intensivmedizinischer Therapieindikation. . Medizinische Klinik - Intensivmedizin und Notfallmedizin, 108, 214-222,
- Koch, A. , Weiskirchen, R., Bruensing, J., Duckers, H., Buendgens, L., Kunze, J., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis.. Mediators of Inflammation, 2013, [3.418]
- Koch, A. , Buendgens, L., Duckers, H., Bruensing, J., Matthes, M., Kunze, J., Herbers, U., Lutz, H. H., Luedde, T., Tischendorf, J. J., Trautwein, C., Tacke, F. (2013): Gastrointestinal bleeding in liver cirrhosis at the ICU. Zeitschrift für Gastroenterologie, 51 (1), 19-25, [1.357]
- Herbers, U. , Amini-Bavil-Olyaee, S., Mueller, A., Luedde, T., Trautwein, C., Tacke, F. (2013): Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains. Journal of Viral Hepatology, 20 (2), 141-148, [4.179]
- Zimmermann, H. W. , Reuken, P. A., Koch, A., Bartneck, M., Adams, D. H., Trautwein, C., Stallmach, A., Tacke, F., Bruns, T. (2013): Soluble urokinase plasminogen activator receptor (suPAR) is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality.. J Intern Med, 274 (1), 86-100, [1.679]
- Mossanen, J. C. , Tacke F. (2013): Role of lymphocytes in liver cancer.. Oncolmmunology, 2(11), [7.644]
- Borkham-Kamphorst, E. , van de Leur, E., Zimmermann, H. W., Karlmark, K. R., Tihaa, L., Haas, U., Tacke, F., Berger, T., Mak, T. W., Weiskirchen, R. (2013): Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis.. Biochim Biophys Acta, 1832, 660-673, [4.880]
- Sahin, H. , Borkham-Kamphorst, E., Kuppe, C., Zaldivar, M. M., Grouls, C., Al-Samman, M., Nellen, A., Schmitz, P., Heinrichs, D., Berres, M. L., Doleschel, D., Scholten, D., Weiskirchen, R., Moeller, M. J., Kiessling, F., Trautwein, C., Wasmuth, H. E. (2012): Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology, 55 (5), 1610-1619, [11.711]
- Meurer, S. K. , Esser, M., Tihaa, L., Weiskirchen, R. (2012): BMP-7/TGF-beta1 signalling in myoblasts: Components involved in signalling and BMP-7-dependent blockage of TGF-beta-mediated CTGF expression. European Journal of Cell Biology, 91, 450-463, [4.011]
- Borkham-Kamphorst, E. , van Roeyen, C. R., Van de Leur, E., Floege, J., Weiskirchen, R. (2012): CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. Journal of Cell Communication and Signaling, 6, 11-25, [3.123]
- van Roeyen CRC, Boor P. , Borkham-Kamphorst E, Rong S, Kunter U, Martin IV, Kaitovic A, Fleckenstein S, Perbal B, Weiskirchen R, Ostendorf T, Floege J. (2012): A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and anti-mesangioproliferative effects. American Journal of Pathology, 180, 1979-1990, [4.206]
- Borkham-Kamphorst, E. , Huss, S., Van de Leur, E., Haas, U., Weiskirchen, R. (2012): Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis. Liverer International, 32 (9), 1342-1353, [4.470]
- Boaru, S. G. , Borkham-Kamphorst, E., Tihaa, L., Haas, U., Weiskirchen, R. (2012): Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. Journal of Inflammation (Lond), 9, 49. 2012, [1.975]
- Bergmann, C. , Weiskirchen, R. (2012): It's not all in the cilium, but on the road to it: Genetic interaction network in polycystic kidney and liver diseases and how trafficking and quality control matter. Journal of Hepatology, 56, 1201-1203, [10.590]
- Reichenbach, V. , Fernandez-Varo, G., Casals, G., Oro, D., Ros, J., Melgar-Lesmes, P., Weiskirchen, R., Morales-Ruiz, M.W., Jimenez, W. (2012): Transduction of the liver with dominant-negative soluble PDGFRbeta improves systemic hemodynamics, portal pressure and fibrosis in CCl4-treated rats. Journal of Hepatology, 57, 967-973, [10.590]
- Tacke, F. , Weiskirchen, R. (2012): Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques. Expert Review of Gastroenterology Hepatology, 6, 67-80, [2.796]
- Yagmur, E. , Koch, A., Haumann, M., Kramann, R., Trautwein, C., Tacke, F. (2012): Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity. Clinical Biochemistry, 45, 82-87, [2.382]
- Zimmermann, H. W. , Trautwein, C., Tacke, F. (2012): Functional role of monocytes and macrophages for the inflammatory response in acute liver injury. Frontiers in Physiology, 3, 56, [4.031]
- Parahuleva, M. S. , Holschermann, H., Zandt, D., Pons-Kuhnemann, J., Parviz, B., Weiskirchen, R., Staubitz, A., Tillmanns, H., Erdogan, A., Kanse, S. M. (2012): Circulating factor VII activating protease (FSAP) is associated with clinical outcome in acute coronary syndrome. Circulation Journal, 76, 2653-2661, [4.124]
- Tacke, F. , Shirvani-Dastgerdi, E. (2012): Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro. Hepatitis Monthly, 12, 357-360, [1.932]
- Seidler, S. , Zimmermann, H. W., Weiskirchen, R., Trautwein, C., Tacke, F. (2012): Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes. BMC Gastroenterology, 12, 38, [2.101]
- Schneider, C. , Teufel, A., Yevsa, T., Staib, F., Hohmeyer, A., Walenda, G., Zimmermann, H. W., Vucur, M., Huss, S., Gassler, N., Wasmuth, H. E., Lira, S. A., Zender, L., Luedde, T., Trautwein, C., Tacke, F. (2012): Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. Gut, 61(12), 1733-43, [14.921]
- Tacke, F. (2012): Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo. Fibrogenesis Tissue Repair, 5 (1), 27, [2.329]
- Roderburg, C. , Mollnow, T., Bongaerts, B., Elfimova, N., Vargas Cardenas, D., Berger, K., Zimmermann, H., Koch, A., Vucur, M., Luedde, M., Hellerbrand, C., Odenthal, M., Trautwein, C., Tacke, F., Luedde, T. (2012): Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. PLoS One, 7 (3), e32999, [3.057]
- Nevzorova, Y. A. , Bangen, J. M., Hu, W., Haas, U., Weiskirchen, R., Gassler, N., Huss, S., Tacke, F., Sicinski, P., Trautwein, C., Liedtke, C. (2012): Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice.. Hepatology, 56 (3), 1140-1149, [11.711]
- Heymann, F. , Hammerich, L., Storch, D., Bartneck, M., Huss, S., Russeler, V., Gassler, N., Lira, S. A., Luedde, T., Trautwein, C., Tacke, F. (2012): Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology, 55 (3), 898-909, [11.711]
- Kabgani N. , Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti R, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ. (2012): Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS ONE, 7, [3.057]
- Baeck, C. , Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., Trautwein, C., Tacke, F. (2012): Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut, 61 (3), 416-426, [14.921]
- Bartneck, M. , Ritz, T., Keul, H. A., Wambach, M., Bornemann, J., Gbureck, U., Ehling, J., Lammers, T., Heymann, F., Gassler, N., Ludde, T., Trautwein, C., Groll, J., Tacke, F. (2012): Peptide-functionalized gold nanorods increase liver injury in hepatitis. ACS Nano, 6 (10), 8767-8777, [13.334]
- Koch, A. , Zimmermann, H. W., Baeck, C., Schneider, C., Yagmur, E., Trautwein, C., Tacke, F. (2012): Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis. Clinical Biochemistry, 45, 429-435, [2.382]
- Scholten, D. , Weiskirchen, R. (2011): Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury. Hepatology, 53 (3), 1048-1051, [11.711]
- Weiskirchen, R. (2011): CCN proteins in normal and injured liver. Frontiers in Bioscience, 16, 1939-1961, [2.484]
- Rauen, T. , Weiskirchen, R., Floege, J. (2011): In search of early events in the development of chronic kidney disease: the emerging role for lipocalin-2/NGAL. Nephrology Dialysis Transplantation, 26, 445-447, [4.085]
- Meurer, S. K. , Tihaa, L., Borkham-Kamphorst, E., Weiskirchen, R. (2011): Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. Cellular Signalling, 23 (4), 683-699, [4.191]
- Hellerbrand, C. , Weiskirchen, R. (2011): Does it matter not only how much but also when we eat to induce fatty liver?. Hepatology, 54 (3), 1096-1099, [11.711]
- Tacke, F. , Zimmermann, H. W., Trautwein, C., Schnabl, B. (2011): CXCL5 plasma levels decrease in patients with chronic liver disease. Journal of Gastroenterology & Hepatology, 26 (3), 523-529, [3.322]
- Zimmermann, H. W. , Tacke, F. (2011): Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. Inflammation & Allergy - Drug Targets, 10 (6), 509-536, [1.560]
- Zimmermann, H. W. , Seidler, S., Gassler, N., Nattermann, J., Luedde, T., Trautwein, C., Tacke, F. (2011): Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS One, 6 (6), e21381, [3.057]
- Tacke, F. , Kurts, C. (2011): Infiltrating monocytes versus resident Kupffer cells: do alternatively activated macrophages need to be targeted alternatively?. Hepatology, 54 (6), 2267-2270, [11.711]
- Tacke, F. , Zimmermann, H. W., Berres, M. L., Trautwein, C., Wasmuth, H. E. (2011): Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases. Liver International, 31 (6), 840-849, [4.470]
- Tacke, F. , Kanig, N., En-Nia, A., Kaehne, T., Eberhardt, C. S., Shpacovitch, V., Trautwein, C., Mertens, P. R. (2011): Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease. BMC Cancer, 11, 185, [3.265]
- Hanssen, L. , Frye, B. C., Ostendorf, T., Alidousty, C., Djudjaj, S., Boor, P., Rauen, T., Floege, J., Mertens, P. R., Raffetseder, U. (2011): Y-box binding protein-1 mediates profibrotic effects of calcineurin inhibitors in the kidney. Journal of Immunology, 187 (1), 298-308, [4.179]
- Roderburg, C. , Urban, G. W., Bettermann, K., Vucur, M., Zimmermann, H., Schmidt, S., Janssen, J., Koppe, C., Knolle, P., Castoldi, M., Tacke, F., Trautwein, C., Luedde, T. (2011): Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis.. Hepatology, 53, 209-218, [11.711]
- Roderburg, C. , Trautwein, C., Luedde, T. (2011): MicroRNA-199a/b-3p: a new star in the liver microcosmos. Hepatology, 54, 729-731,
- Pieper-Furst, U. , Hall, R., Huss, S., Hochrath, K., Fischer, H. P., Tacke, F., Weiskirchen, R., Lammert, F. (2011): Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. Biochimica et Biophysica Acta, 1812 (12), 1640-1648, [5.158]
- Liedtke, C. , Bangen, J. M., Freimuth, J., Beraza, N., Lambertz, D., Cubero, F. J., Hatting, M., Karlmark, K. R., Streetz, K. L., Krombach, G. A., Tacke, F., Gassler, N., Riethmacher, D., Trautwein, C. (2011): Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury. Gastroenterology, 141 (6), 2176-2187, [18.187]
- Koch, A. , Voigt, S., Sanson, E., Duckers, H., Horn, A., Zimmermann, H. W., Trautwein, C., Tacke, F. (2011): Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients. Critical Care, 15 (1), R45, [4.950]
- Koch, A. , Voigt, S., Kruschinski, C., Sanson, E., Duckers, H., Horn, A., Yagmur, E., Zimmermann, H., Trautwein, C., Tacke, F. (2011): Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Critical Care, 15 (1), [4.950]
- Koch, A. , Sanson, E., Voigt, S., Helm, A., Trautwein, C., Tacke, F. (2011): Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients. Journal of Critical Care, 26, 166-174, [2.445]
- Koch, A. , Horn, A., Duckers, H., Yagmur, E., Sanson, E., Bruensing, J., Buendgens, L., Voigt, S., Trautwein, C., Tacke, F. (2011): Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Crit Care, 15, R266,
- Koch, A. , Horn, A., Duckers, H., Yagmur, E., Sanson, E., Bruensing, J., Buendgens, L., Voigt, S., Trautwein, C., Tacke, F. (2011): Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Critical Care, 15, R266, [4.950]
- Henkel, C. , Schwamborn, K., Zimmermann, H. W., Tacke, F., Kuhnen, E., Odenthal, M., Groseclose, M. R., Caprioli, R. M., Weiskirchen, R. (2011): From proteomic multimarker profiling to interesting proteins: thymosin-beta(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions. Journal of Cellular an Molecular Medicine, 15 (10), 2176-2188, [4.938]
- Berres, M. L. , Trautwein, C., Schmeding, M., Eurich, D., Tacke, F., Bahra, M., Neuhaus, P., Neumann, U. P., Wasmuth, H. E. (2011): Serum chemokine CXC ligand 10 (CXCL10) predicts fibrosis progression after liver transplantation for hepatitis C infection. Hepatology, 53 (2), 596-603, [11.711]
- Hammerich, L. , Heymann, F., Tacke, F. (2011): Role of IL-17 and Th17 cells in liver diseases. Clinical and Developmental Immunology, [3.603]
- Amini-Bavil-Olyaee, S. , Pourkarim, M. R., Schaefer, S., Mahboudi, F., Van Ranst, M., Adeli, A., Trautwein, C., Tacke, F. (2011): Single-step real-time PCR to quantify hepatitis B virus and distinguish genotype D from non-D genotypes. Journal of Viral Hepatology, 18, 300-304, [4.179]
- Zimmermann, H. W. , Seidler, S., Nattermann, J., Gassler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J., Luedde, T., Weiskirchen, R., Trautwein, C., Tacke, F. (2010): Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One, 5 (6), e11049, [3.057]
- Zaldivar, M. M. , Pauels, K., von Hundelshausen, P., Berres, M. L., Schmitz, P., Bornemann, J., Kowalska, M. A., Gassler, N., Streetz, K. L., Weiskirchen, R., Trautwein, C., Weber, C., Wasmuth, H. E. (2010): CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology, 51 (4), 1345-1353, [11.711]
- Huss, S. , Schmitz, J., Goltz, D., Fischer, H. P., Buttner, R., Weiskirchen, R. (2010): Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis. Fibrogenesis Tissue Repair, 3, 10, [2.329]
- Berres, M. L. , Koenen, R. R., Rueland, A., Zaldivar, M. M., Heinrichs, D., Sahin, H., Schmitz, P., Streetz, K. L., Berg, T., Gassler, N., Weiskirchen, R., Proudfoot, A., Weber, C., Trautwein, C., Wasmuth, H. E. (2010): Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Journal of Clinical Investigation, 120 (11), 4129-4140, [12.575]
- Wasmuth, H. E. , Weiskirchen, R. (2010): Pathogenesis of liver fibrosis: modulation of stellate cells by chemokines. Zeitschrift für Gastroenterologie, 48 (1), 38-45, [1.357]
- Wasmuth, H. E. , Weiskirchen, R. (2010): Personalized medicine in hepatitis C: from genome-wide association studies to clinical practice. Hepatology, 51 (6), 2223-2225, [11.711]
- Bohr, W. , Kupper, M., Hoffmann, K., Weiskirchen, R. (2010): Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein. PLoS One, 5 (12), e16000, [3.057]
- Sahin, H. , Trautwein, C., Wasmuth, H. E. (2010): Functional role of chemokines in liver disease models. Nat Rev Gastroenterol Hepatol, 7 (12), 682-690, [14.435]
- Seidler, S. , Zimmermann, H. W., Bartneck, M., Trautwein, C., Tacke, F. (2010): Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults.. BMC Immunol, 11, 30, [2.161]
- Koch, A. , Weiskirchen, R., Sanson, E., Zimmermann, H. W., Voigt, S., Duckers, H., Trautwein, C., Tacke, F. (2010): Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation. Crit Care, 14, R179, [4.950]
- Bomble, M. , Tacke, F., Rink, L., Kovalenko, E., Weiskirchen, R. (2010): Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts. Biochem Biophys Res Commun, 396, 342-347, [2.371]
- Amini-Bavil-Olyaee, S. , Vucur, M., Luedde, T., Trautwein, C., Tacke, F. (2010): Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains. Journal of Virology, 84 (29, 1026-1033, [4.606]
- Karlmark, K. R. , Zimmermann, H. W., Roderburg, C., Gassler, N., Wasmuth, H. E., Luedde, T., Trautwein, C., Tacke, F. (2010): The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology, 52 (5), 1769-1782, [11.711]
- Tacke F , Weiskirchen R. (2010): Liver fibrosis - pathogenesis and novel therapeutic approaches. Der Internist, 51 (1), 21-29, [0.336]
- Vucur, M. , Roderburg, C., Bettermann, K., Tacke, F., Heikenwalder, M., Trautwein, C., Luedde, T. (2010): Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?. Oncotarget, 1 (5), 373-378, [5.008]
- Koch, A. , Weiskirchen, R., Zimmermann, H. W., Sanson, E., Trautwein, C., Tacke, F. (2010): Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators of Inflammation, [3.418]
- Bettermann, K. , Vucur, M., Haybaeck, J., Koppe, C., Janssen, J., Heymann, F., Weber, A., Weiskirchen, R., Liedtke, C., Gassler, N., Muller, M., de Vos, R., Wolf, M. J., Boege, Y., Seleznik, G. M., Zeller, N., Erny, D., Fuchs, T., Zoller, S., Cairo, S., Buendia, M. A., Prinz, M., Akira, S., Tacke, F., Heikenwalder, M., Trautwein, C., Luedde, T. (2010): TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell, 17 (5), 481-496, [23.214]
- Weiskirchen, R. , Wasmuth, H. E. (2009): The genes that underlie fatty liver disease: the harvest has begun. Hepatology, 49, 692-694,
- Weiskirchen, R. , Liedtke, C., Trautwein, C. (2009): When sleeping beauty wakes up and jumps into a cancer-minded environment. Hepatology, 49, 2122-2124., [11.711]
- Wasmuth, H. E. , Lammert, F., Zaldivar, M. M., Weiskirchen, R., Hellerbrand, C., Scholten, D., Berres, M. L., Zimmermann, H., Streetz, K. L., Tacke, F., Hillebrandt, S., Schmitz, P., Keppeler, H., Berg, T., Dahl, E., Gassler, N., Friedman, S. L., Trautwein, C. (2009): Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.. Gastroenterology, 137, 309-319, 301-303, [18.187]
- Wasmuth, H. E , Tag, C. G., Van de Leur, E., Hellerbrand, C., Mueller, T., Berg, T., Puhl, G., Neuhaus, P., Samuel, D., Trautwein, C., Kanse, S. M., Weiskirchen, R. (2009): The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.. Hepatology, 49, 775-780, [11.711]
- Nattermann, J. , Tacke, F. (2009): The structure behind diversity: covariance networks in hepatitis C virus sequences are associated with treatment response.. Hepatology, 49, 1767-1769, [11.711]
- Kovalenko, E. , Tacke, F., Gressner, O. A., Zimmermann, H. W., Lahme, B., Janetzko, A., Wiederholt, T., Berg, T., Muller, T., Trautwein, C., Gressner, A. M., Weiskirchen, R. (2009): Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.. J Viral Hepat, 16, 612-620, [4.179]
- Koch, A. , Gressner, O. A., Sanson, E., Tacke, F., Trautwein, C. (2009): Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients.. Crit Care, 13, R95, [4.950]
- Karlmark, K. R. , Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., Tacke, F (2009): Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology, 50, 261-274, [11.711]
- Heymann, F. , Trautwein, C., Tacke, F. (2009): Monocytes and macrophages as cellular targets in liver fibrosis. Inflamm Allergy Drug Targets, 8, 307-318, [1.560]
- Berres, M. L. , Trautwein, C., Zaldivar, M. M., Schmitz, P., Pauels, K., Lira, S. A., Tacke, F., Wasmuth, H. E. (2009): The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biol Chem, 390, 1039-1045, [2.710]
- Amini-Bavil-Olyaee, S. , Herbers, U., Mohebbi, S. R., Sabahi, F., Zali, M. R., Luedde, T., Trautwein, C., Tacke, F. (2009): Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome. J Hepatol, 51, 647-654, [10.590]