P10 Prof. Dr. Kurts
Inflammasomaktivation und Nierenfibrose bei Kristallnephropathie

Kristallpräzipitation verursacht chronische tubulointerstitielle Entzündung, Nierenfibrose und terminaler Niereninsuffizienz. Kristallpräzipitation verursacht chronische tubulointerstitielle Entzündung, Nierenfibrose und terminaler Niereninsuffizienz. In der letzten Förderperiode haben wir eine wichtige Rolle renaler dendritischer Zellen, regulatorischer T-Zellen, von Makrophagen und des Inflammasoms hierbei gezeigt. In der nächsten Förderperiode möchten wir unsere Studien auf 3 Modelle der primären Hyperoxalurie (PH) Typ 1, 2 und 3, erweitern, deren klinische Verläufe sich aus unbekannten Gründen stark unterscheiden. Wir werden in alimentärer und erblicher Kristallnephropathie die Fibroseentwicklung und die Immunmechanismen untersuchen und laborchemische und bildgebende Biomarker identifizieren. Wir werden präklinischen Therapiestudien mit Inhibitoren des Inflammasoms, von miRNA223 und ACE durchführen. Schließlich werden wir unsere Biomarkerstudien auf eine große Biobank mit Urinprobe von PH 1, 2 und 3 Patienten anwenden. [...]

Publikationen

• Kurts C. , Ginhoux F., Panzer U. (2020): Kidney dendritic cells: Basic biology and role in health and disease. Nat Rev Nephrol, 16(7), 391-407, [19.684]
• Krebs C. , Schlitzer A., Kurts C. (2020): Drawing a single cell landscape of the human kidney in (pseudo)space and time. Kidney Int, 97(5), 842-844, [8.429]
• Boehner A. , Viehmann S., Kurts C. (2020): Unraveling the complexity of the renal mononuclear phagocytic system by cell lineage tracing. J Am Soc Nephrol, Epub 2020, [8.547]
• Jobin K. , Stumpf N. E., Schwab S., Eichler M., Neubert P., Rauh M., Adamowski M., Babyak O., Hinze D., Sivalingam S., Weisheit C., Hochheiser K., Schmidt S., Meissner M., Garbi N., Abdullah Z., Wenzel U., Hölzel M., Jantsch J., Kurts C. (2020): A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation. Science Translat Med, 12(536), eaay3850, [17.161]
• Rigau M. , Ostrouska S., Fulford T. S., Johnson D. N., Woods K., Ruan Z., McWilliam H. E., Hudson C., Tutuka C., Wheatley A. K., Kent S. J., Villadangos J. A., Pal B., Kurts C., Simmonds J., Pelzing M., Hammet A., Verhagen A. M., Vairo G., Maraskovsky E., Panousis C., Gherardin N. A., Cebon J., Godfrey D. I., Behren A., Uldrich A. P. (2020): Butyrophilin 2A1 mediates phosphoantigen reactivity by γδ T cells. Science 2020, in press,
• Rosenbaum M. , Gewies A., Pechloff K., Heuser C., Engleitner T., Gehring T., Krappmann D., Krebs S., Kriegsmann M., Weichert W., Rad R., Kurts C., Ruland J. (2019): Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun, Epub May 28; 10(1), 2352, [11.878]
• Enders M. , Franken L., Philipp M. S., Kessler N., Baumgart A. K., Eichler M., Wirtz E., Garbi N., Kurts C. (2019): Splenic red pulp macrophages cross-prime early effector CTL that provide rapid defense against viral infections. J Immunol, 204(1), 87-100, [4.718]
• Cossarizza A. , Chang H. D., Radbruch A., Acs A., Adam D., Adam-Klages S., Agace W. W., Aghaeepour N., Akdis M., Allez M., Almeida L. N., Alvisi G., Anderson G., Andrä I., Annunziato F., Anselmo A., Bacher P., Baldari C. T., Bari S., Barnaba V., Barros-Martins J., Battistini L., Bauer W., Baumgart S., Baumgarth N., Baumjohann D., Baying B., Bebawy M., Becher B., Beisker W., Benes V., Beyaert R., Blanco A., Boardman D. A., Bogdan C., Borger J. G., Borsellino G., Boulais P. E., Bradford J. A., Brenner D., Brinkman R. R., Brooks A. E. S., Busch D. H., Büscher M., Bushnell T. P., Calzetti F., Cameron G., Cammarata I., Cao X., Cardell S. L., Casola S., Cassatella M. A., Cavani A., Celada A., Chatenoud L., Chattopadhyay P. K., Chow S., Christakou E., Čičin-Šain L., Clerici M., Colombo F. S., Cook L., Cooke A., Cooper A. M., Corbett A. J., Cosma A., Cosmi L., Coulie P. G., Cumano A., Cvetkovic L., Dang V. D., Dang-Heine C., Davey M. S., Davies D., De Biasi S., Del Zotto G., Dela Cruz G. V., Delacher M., Della Bella S., Dellabona P., Deniz G., Dessing M., Di Santo J. P., Diefenbach A., Dieli F., Dolf A., Dörner T., Dress R. J., Dudziak D., Dustin M., Dutertre C. A., Ebner F., Eckle S. B. G., Edinger M., Eede P., Ehrhardt G. R. A., Eich M., Engel P., Engelhardt B., Erdei A., Esser C., Everts B., Evrard M., Falk C. S., Fehniger T. A., Felipo-Benavent M., Ferry H., Feuerer M., Filby A., Filkor K., Fillatreau S., Follo M., Förster I., Foster J., Foulds G. A., Frehse B., Frenette P. S., Frischbutter S., Fritzsche W., Galbraith D. W., Gangaev A., Garbi N., Gaudilliere B., Gazzinelli R. T., Geginat J., Gerner W., Gherardin N. A., Ghoreschi K., Gibellini L., Ginhoux F., Goda K., Godfrey D. I., Goettlinger C., González-Navajas J. M., Goodyear C. S., Gori A., Grogan J. L., Grummitt D., Grützkau A., Haftmann C., Hahn J., Hammad H., Hämmerling G., Hansmann L., Hansson G., Harpur C. M., Hartmann S., Hauser A., Hauser A. E., Haviland D. L., Hedley D., Hernández D. C., Herrera G., Herrmann M., Hess C., Höfer T., Hoffmann P., Hogquist K., Holland T., Höllt T., Holmdahl R., Hombrink P., Houston J. P., Hoyer B. F., Huang B., Huang F. P., Huber J. E., Huehn J., Hundemer M., Hunter C. A., Hwang W. Y. K., Iannone A., Ingelfinger F., Ivison S. M., Jäck H. M., Jani P. K., Jávega B., Jonjic S., Kaiser T., Kalina T., Kamradt T., Kaufmann S. H. E., Keller B., Ketelaars S. L. C., Khalilnezhad A., Khan S., Kisielow J., Klenerman P., Knopf J., Koay H. F., Kobow K., Kolls J. K., Kong W. T., Kopf M., Korn T., Kriegsmann K., Kristyanto H., Kroneis T., Krueger A., Kühne J., Kukat C., Kunkel D., Kunze-Schumacher H., Kurosaki T., Kurts C., Kvistborg P., Kwok I., Landry J., Lantz O., Lanuti P., LaRosa F., Lehuen A., LeibundGut-Landmann S., Leipold M. D., Leung L. T., Levings M. K., Lino A. C., Liotta F., Litwin V., Liu Y., Ljunggren H. G., Lohoff M., Lombardi G., Lopez L., López-Botet M., Lovett-Racke A. E., Lubberts E., Luche H., Ludewig B., Lugli E., Lunemann S., Maecker H. T., Maggi L., Maguire O., Mair F., Mair K. H., Mantovani A., Manz R. A., Marshall A. J., Martínez-Romero A., Martrus G., Marventano I., Maslinski W., Matarese G., Mattioli A. V., Maueröder C., Mazzoni A., McCluskey J., McGrath M., McGuire H. M., McInnes I. B., Mei H. E., Melchers F., Melzer S., Mielenz D., Miller S. D., Mills K. H. G., Minderman H., Mjösberg J., Moore J., Moran B., Moretta L., Mosmann T. R., Müller S., Multhoff G., Muñoz L. E., Münz C., Nakayama T., Nasi M., Neumann K., Ng L. G., Niedobitek A., Nourshargh S., Núñez G., O'Connor J. E., Ochel A., Oja A., Ordonez D., Orfao A., Orlowski-Oliver E., Ouyang W., Oxenius A., Palankar R., Panse I., Pattanapanyasat K., Paulsen M., Pavlinic D., Penter L., Peterson P., Peth C., Petriz J., Piancone F., Pickl W. F., Piconese S., Pinti M., Pockley A. G., Podolska M. J., Poon Z., Pracht K., Prinz I., Pucillo C. E. M., Quataert S. A., Quatrini L., Quinn K. M., Radbruch H., Radstake T. R. J., Rahmig S., Rahn H. P., Rajwa B., Ravichandran G., Raz Y., Rebhahn J. A., Recktenwald D., Reimer D., Reis E., Sousa C., Remmerswaal E. B. M., Richter L., Rico L. G., Riddell A., Rieger A. M., Robinson J. P., Romagnani C., Rubartelli A., Ruland J., Saalmüller A., Saeys Y., Saito T., Sakaguchi S., Sala-de-Oyanguren F., Samstag Y., Sanderson S., Sandrock I., Santoni A., Sanz R. B., Saresella M., Sautes-Fridman C., Sawitzki B., Schadt L., Scheffold A., Scherer H. U., Schiemann M., Schildberg F. A., Schimisky E., Schlitzer A., Schlosser J., Schmid S., Schmitt S., Schober K., Schraivogel D., Schuh W., Schüler T., Schulte R., Schulz A. R., Schulz S. R., Scottá C., Scott-Algara D., Sester D. P., Shankey T. V., Silva-Santos B., Simon A. K., Sitnik K. M., Sozzani S., Speiser D. E., Spidlen J., Stahlberg A., Stall A. M., Stanley N., Stark R., Stehle C., Steinmetz T., Stockinger H., Takahama Y., Takeda K., Tan L., Tárnok A., Tiegs G., Toldi G., Tornack J., Traggiai E., Trebak M., Tree T. I. M., Trotter J., Trowsdale J., Tsoumakidou M., Ulrich H., Urbanczyk S., van de Veen W., van den Broek M., van der Pol E., van Gassen S., van Isterdael G., van Lier R. A. W., Veldhoen M., Vento-Asturias S., Vieira P., Voehringer D., Volk H. D., von Borstel A., von Volkmann K., Waisman A., Walker R. V., Wallace P. K., Wang S. A., Wang X. M., Ward M. D., Ward-Hartstonge K. A., Warnatz K., Warnes G., Warth S., Waskow C., Watson J. V., Watzl C., Wegener L., Weisenburger T., Wiedemann A., Wienands J., Wilharm A., Wilkinson R. J., Willimsky G., Wing J. B., Winkelmann R., Winkler T. H., Wirz O. F., Wong A., Wurst P., Yang J. H. M., Yang J., Yazdanbakhsh M., Yu L., Yue A., Zhang H., Zhao Y., Ziegler S. M., Zielinski C., Zimmermann J., Zychlinsky A. (2019): Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol, Oct;49(10), 1457-1973, [4.695]
• Graefe C. , Eichhorn L., Wurst P., Kleiner J., Heine A., Panetas I., Abdulla Z., Hoeft A., Frede S., Kurts C., Endl E., Weisheit C. K. (2019): Optimized Ki-67 staining in murine cells: a tool to determine cell proliferation. Mol Biol Rep, 2019 46(4), 4631-4643, [2.107]
• Kurts C. , Meyer-Schwesinger C. (2019): Protecting the kidney against autoimmunity and inflammation. Nat Rev Nephrol, Feb;15(2), 66-68, [19.684]
• Martin-Higueras C. , Ludwig-Portugall I., Hoppe B., Kurts C. (2019): Targeting kidney inflammation as a new therapy for Primary Hyperoxaluria?. Nephrol Dial Transpl, 34(6), 908-914, [4.198]
• Reinicke A. T. , Raczkowski F., Mühlig M., Schmucker P., Lischke T., Reichelt J., Schneider E., Zielinski S., Sachs M., Jurack E., Tolosa E., Kurts C., Mittrücker H. W., Meyer-Schwesinger C. (2019): Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules. J Immunol., 2019 Oct 1;203(7), 1730-1742, [4.718]
• Kelly J. , Minoda Y., Meredith T., Cameron G., Philipp M. S., Pellicci D. G., Corbett A. J., Kurts C., Gray D. H., Godfrey D. I., Kannourakis G., Berzins S. P. (2019): Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers. Immunol Cell Biol., 97(8), 689-699, [3.947]
• Neubert P. , Weichselbaum A., Reitinger C., Schatz V., Schröder A., Ferdinand J. R., Simon M., Bär A. L., Brochhausen C., Gerlach R. G., Tomiuk S., Hammer K., Wagner S., van Zandbergen G., Binger K. J., Müller D. N., Kitada K., Clatworthy M. R., Kurts C., Titze J., Abdullah Z., Jantsch J. (2019): HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy, 15(11), 1899-1916, [11.059]
• Puelles V. G. , Fleck D., Ortz L., Papadouri S., Strieder T., Boehner A., van der Wolde J. W., Vogt M., Saritas T., Kuppe C., Fuss A., Menzel S., Klinkhammer B. M., Müller-Newen G., Heymann F., Decker L., Braun F., Kretz O., Huber T. B., Susaki E. A., Ueda H. R., Boor P., Floege J., Kramann R., Kurts C., Bertram J. F., Spehr M., Nikolic-Paterson D. J., Moeller M. J. (2019): 3D analysis of rapidly progressive glomerulonephritis using optical tissue clearing. Kidney Int, 96, 505-516, [8.306]
• Meissner M. , Viehmann S. F., Kurts C. (2018): DAMPening sterile inflammation of the kidney. Kidney Int, 95(3), 489-491, [8.429]
• Wenzel U. O. , Bode M., Kurts C., Ehmke H. (2018): Salt, inflammation, IL-17 and hypertension. Br. J Pharmacol, 176(2), 1853-1863, [6.810]
• Ahadzadeh E. , Rosendahl A., Czesla D., Steffens P., Prüßner L., Meyer-Schwesinger C., Wanner N., Paust H. J., Huber T. B., Stahl R. A., Wiech T., Kurts C., Seniuk A., Ehmke H., Wenzel U. O. (2018): The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension. Am J Physiol Renal Physiol, Sep, [3.611]
• Gotot J. , Dhana E., Yagita H., Kaiser R., Ludwig-Portugall I., Kurts C. (2018): Antigen-specific Helios–, Neuropilin-1– Tregs induce apoptosis of autoreactive B cells via PD-L1. Immunol Cell Biol, 96(8), 852-862, [3.947]
• Breitbach M. , Kimura K., Luis T. C., Fuegemann C. J.; Woll P. S., Hesse M.; Facchini R., Rieck S., Jobin K., Reinhardt J., Ohneda O., Wenzel D., Geisen C., Kurts C., Kastenmuller W., Holzel M., Jacobsen S. E. W., Sten E. W., Fleischmann B. K. (2018): In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche. Cell Stem Cell, 22(2), 262-7, [21.464]
• Welz M. , Eickhoff S., Abdullah Z., Trebicka J., Gartlan K. H., Spicer J. A., Demetris A. J., Akhlaghi H., Anton M., Manske K., Zehn D., Nieswandt B., Kurts C., Trapani J. A., Knolle P., Wohlleber D., Kastenmüller W. (2018): Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun, 9(1), 4805, [11.878]
• Viehmann S. , Böhner A. S., Kurts C., Brähler S. (2017): The multifaceted role of the renal mononuclear phagocyte system. Cell Immunol, 330, 97-104, [8.213]
• Reich B. , Viehmann S., Kurts C. (2017): Plasmacytoid dendritic cells: important players in human kidney allograft rejection. Kidney Int, 93(2), 301-303, [8.306]
• Dhana E. , Ludwig-Portugall I., Kurts C. (2017): Role of immune cells in crystal-induced kidney fibrosis.. Mat Biol, 68-69, 280-292, [6.986]
• Jantsch J. , Schultze J. L., Kurts C. (2017): Immunophysiology: Macrophages as key regulators of homeostasis in various organs. Pflugers Arch - Eur J Physiol, 469, 363-364, [2.208]
• Schwab S. , Jobin K., Kurts C. (2017): Urinary tract infection: Recent insight into the evolutionary arms race between uropathogenic E.coli and our immune system. Nephrol Dial Transplant 1, 32(12), 1977-1983, [4.198]
• Heuser C., Gotot J. , Piotrowski E. C., Philipp M. S., Courrèges J. F., Otte M. S., Guo L., Schmid-Burgk J. L., Hornung V., Heine A. K., Knolle P. A., Garbi N., Serfling E., Evaristo C., Thaiss F., Kurts C. (2017): Prolonged IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells. Cell Rep, 21(3), 578–586, [7.815]
• Brähler S. , Zinselmeyer B. H., Raju S., Nitschke M., Suleiman H., Saunders B. T., Johnson M. W., Boehner A., Viehmann S., Theisen D. J., Kretzer N. M., Briseno C. G., Zaitsev K., Ornatsky O., Chang Q., Carrero J., Kopp J. B., Artyomov M. N., Kurts C., Murphy K. M., Miner J. H., Shaw A. S. (2017): Opposing roles of dendritic cell subsets in experimental glomerulonephritis. J Am Soc Nephrol, 29(1), 138-154, [8.547]
• Holland T. , Wohlleber D., Marx S., Kreutzberg T., Vento-Asturias S., Schmitt-Mbamunyo S., Welz M., Janas M., Komander K., Eickhoff S., Brewitz A., Hasenberg M., Männ L., Gunzer M., Wilhelm C., Kastenmüller W., Knolle P., Abdullah Z., Kurts C., Garbi N. (2017): Rescue of T-cell function during persistent pulmonary adenoviral infection by TLR9 activation. J Allergy Clin Immun, 141(1), 416-419, [3.557]
• Heine A. , Flores C., Gevensleben H., Diehl L., Heikenwälder M., Ringelhan M., Janssen K. P., Nitsche U., Garbi N., Brossart P., Knolle P. A., Kurts C., Höchst B. (2017): Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination. Onkoimmunol, 6(8), e1338995, [5.333]
• Pohl J. M. , Gutweiler S., Thiebes S., Woeste M., Job A., Gunzer M., Jung S., Agace W., Kurts C., Engel D. R. (2017): Irf4-dependent CD103+ CD11b+ dendritic cells and the microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative Ileus. Gut, 12, 2110-20, [17.160]
• Rieck M. , Kremser C., Jobin K., Mettke E., Kurts C., Gräler M., Willecke K., Kolanus W. (2017): Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. Eur J Immunol, 47(4), 677-684, [4.695]
• Brewitz A. , Eickhoff S., Dähling S., Quast T., Bedoui S., Kroczek R. A., Kurts C., Garbi N., Barchet W., Iannacone M., Klauschen F., Kolanus W., Kaisho T., Colonna M., Germain R. N., Kastenmüller W. (2017): CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity, 46(2), 205-219, [21.522]
• Klingberg A. , Hasenberg A., Ludwig-Portugall I., Medyukhina A., Männ L., Brenzel A., Engel D. R., Figge M. T., Kurts C., Gunzer M. (2017): Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy. J Am Soc Nephrol, 28(2), 452-459, [8.547]
• Wittlich M. , Dudek M., Böttcher J. P., Schanz O., Hegenbarth S., Bopp T., Schmitt E., Kurts C., Garbers C., Rose John S., Knolle P. A., Wohlleber D. (2017): Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2. J Hepatol, 66(5), 978-986, [18.946]
• Beyer, M. , Abdullah Z., Chemnitz J.M., Maisel D., Sander J., Lehmann C., Thabet Y., Shinde P.V., Schmidleithner L., Köhne M., Trebicka J., Schierwagen R., Hofmann A., Popov A., Lang K.S., Oxenius A., Buch T., Kurts C., Heikenwalder M., Fätkenheuer G., Lang P.A., Hartmann P., Knolle P.A., Schultze J.L. (2016): Tumor necrosis factor impairs CD4+ T Cell-mediated immune control in chronic viral infection. Nature Immunology, , accepted, [19.381]
• Ludwig-Portugall I., , Bartok E., Dhana E., Evers B.D.G., Primiano M.J., Hall J.P., Franklin B.S., Knolle P.A., Hornung V., Hartmann G., Boor P, Latz E., Kurts C. (2016): An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. Kidney International, 90(3), 525–539, [7.683]
• Jobin K. , Heuser C., Kurts C. (2016): A grain of salt on kidney dendritic cell function in allograft rejection. Kidney International, 89(1), 14–16 ], [7.683]
• Hackstein CP , Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z. (2016): Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut,, , 1-12, [14.921]
• Gotot J. , Piotrowski E., Otte M.S., Tittel A.P., Linlin G., Yao C., Ziegelbauer K., Panzer U., Garbi N., Kurts C., Thaiss F (2016): Inhibitor of NFkB Kinase Subunit 2 Blockade Hinders the Initiation but Aggravates the Progression of Crescentic GN. Journal of the American Society of Nephrology, 27(7), 1917-1924, [8.491]
• Evers B.D.G. , Engel D.R., Böhner A.M.C., Tittel A.P., Krause T.A., Heuser C., Garbi N., Kastenmüller W., Mack M., Tiegs G., Panzer U., Boor P., Ludwig-Portugall I., Kurts C. (2016): CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10–Producing Regulatory T Cells. Journal of the American Society of Nephrology, 27(11), 3368-3382, [8.491]
• Djudjaj, S. , Lue, H. J., Rong, S., Papasotiriou, M., Klinkhammer, B. M., Zok, S., Klaener, O., Braun, G. S., Lindenmeyer, M. T., Cohen, C. D., Bucala, R., Tittel, A. P., Kurts, C., Moeller, M. J., Floege, J., Boor, P. (2016): Macrophage migration inhibitory factor mediates proliferative glomerulonephritis via CD74. Journal of the American Society of Nephrology, 27 (6), 1650-1664, [8.491]
• Abdullah Z. , Kurts C. (2016): More trouble with FGF23: a novel role in systemic immunosuppression. Kidney International, 89(6), 1176–1177, [7.683]
• Heymann, F. , Peusquens, J., Ludwig-Portugall, I., Kohlhepp, M., Ergen, C., Niemietz, P., Martin, C., van Rooijen, N., Ochando, J.C., Randolph, G.J., Luedde, T., Ginhoux, F., Kurts, C., Trautwein, C., Tacke, F (2015): Liver inflammation abrogates immunological tolerance induced by Kupffer cells.. Hepatology, 62 (1), 279-91, [11.711]
• Hoechst, B. , Mikulec ,J., Baccega, T., Metzger, C., Welz, M., Peusquens, J., Tacke, F., Knolle, P., Kurts, C., Diehl, L., Ludwig-Portugall, I. (2015): Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis.. PLoS One, 10 (3) e0119662, [3.057]
• Gottschalk C (2015): The debate about dendritic cells and macrophages in the kidney.. Front Immunol,
• Franken L (2015): Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.. Sci Rep, [5.580]
• Böttcher JP , Beyer M., Meissner F., Abdullah Z., Sander J., Höchst B., Eickhoff S., Rieckmann J.C., Russo C., Bauer T., Flecken T., Giesen D., Engel D., Jung S., Busch D.H., Protzer U., Thimme R., Mann M., Kurts C., Schultze J.L., Kastenmüller W., Knolle P.A. (2015): Functional classification of memory CD8(+) T cells by CX3CR1 expression.. Nature Communications, [11.470]
• Engel, D. R. , Krause, T., Snelgrove, S., Thiebes, S., Boor, P., Kitching, R., Kurts, C. (2015): (2015): CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.. J Immunol, 194, 1628-1638, [4.920]
• Dickerhof, N. (2015): Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function.. Free Radical Biol Med, [5.740]
• Weisheit C (2014): Dendritic Cells and Macrophages: Sentinels in the Kidney. Clinical Jpurnal of the American Society of Nephrology, 10 (10), 1841-1851, [4.657]
• Schölzel K (2014): Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance.. Journal of Hepatology, 61 (3), 600-608, [10.590]
• Krause, T. A. , Alex, A.F., Engel, D.R., Kurts, C., Eter, N. (2014): VEGF-production by CCR2-dependent macrophages contributes to laser-induced choroidal neovascularization. PLos One, 9 (4), [3.057]
• Böttcher J.P. , Schanz, O., Garbers, C., Zaremba, A., Hegenbarth, S., Kurts, C., Beyer, M., Schultze, J.L., Kastenmüller, W., Rose-John, S., Knolle, P.A. (2014): IL-6 trans-signaling dependent rapid development of cytotoxic CD8+ T cell function.. Cell Reports, 8 (5), 1318-1327, [7.870]
• Schiwon M. , Weisheit, C., Franken, L., Gutweiler, S., Dixit, A., Meyer-Schwesinger, C., Pohl, J. M., Maurice, N. J., Thiebes, S., Lorenz, K., Quast, T., Fuhrmann, M., Baumgarten, G., Lohse, M. J., Opdenakker, G., Bernhagen, J., Bucala, R., Panzer, U., Kolanus, W., Gröne, H. J., Garbi, N., Kastenmüller, W., Knolle, PA., Kurts, C., Engel, D. R. (2014): Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.. Cell, 156(3), 456-468, [28.710]
• Böttcher JP , Schanz, O., Wohlheber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., Atreya, I., Neurath, M.F., Busch, D.H., Schmitt, E., van Endert, P., Kolanus, W., Kurts, C., Schultze, J.L., Diehl, L., Knolle, P.A., (2013): Liver-Primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. Cell Reports, 3 (3), 779-795, [7.870]
• Kurts, C. , Panzer, U., Anders, H.J., Rees, A.J. (2013): The immune system and kidney disease: basic concepts and clinical implications.. Nature Reviews Immunology, 13 (10), 738-753, [39.416]
• Huang L.R. , Wohlleber, D., Reisinger, F., Jenne, C.N., Cheng, R.L., Abdullah, Z., Schildberg, F.A., Odenthal, M., Dienes, H.P., van Roijen, N., Schmitt, E., Garbi, N., Croft, M., Kurts, C., Kubes, P., Protzer, U., Heikenwalder, M., Knolle, P.A. (2013): Intrahepatic myeloid cell-aggregates enable local CD8+ T cell expansion and successful immunotherapy against chronic viral liver infection.. Nature Immunology, 14 (6), 5742-583, [19.381]
• Hochheiser, K. , Heuser, C., Krause, T.A., Teteris, S., Ilias, A., Weisheit, C., Hoss, F., Tittel, A.P., Knolle, P.A., Panzer, U., Engel, D.R., Tharaux, P.-L., Kurts, C. (2013): Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression.. The Journal of Clinical Investigation, 123 (10), 4242-4254, [12.575]
• Gottschalk, C. , Damuzzo, V., Gotot, J., Kroczek, R.A., Yagita, H., Murphy, K.M., Knolle, P.A., Ludwig-Portugall, I., Kurts, C. (2013): Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens.. Journal of the American Society of Nephrology, 24 (4), 543-549, [8.491]
• Snelgrove, S. L. , Kausman, J. Y., Lo, C., Lo, C., Ooi, J. D., Coates, P. T., Hickey, M. J., Holdsworth, S. R., Kurts, C., Engel, D. R., Kitching, A. R. (2012): Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. The American Journal of Pathology, 180 (1), 91-103, [4.206]
• Tittel, A. P. , Heuser, C., Ohliger, C., Llanto, C., Yona, S., Hammerling, G. J., Engel, D. R., Garbi, N., Kurts, C. (2012): Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nature Methods, 9 (4), 385-390, [25.328]
• Teteris, S. A. , Hochheiser, K., Kurts, C. (2012): Isolation of functional dendritic cells from murine kidneys for immunological characterization. Nephrology (Carlton), 17, 364-371,
• Sicking, E. M. , Fuss, A., Uhlig, S., Jirak, P., Dijkman, H., Wetzels, J., Engel, D. R., Urzynicok, T., Heidenreich, S., Kriz, W., Kurts, C., Ostendorf, T., Floege, J., Smeets, B., Moeller, M. J. (2012): Subtotal ablation of parietal epithelial cells induces crescent formation. Journal of the American Society of Nephrology, 23, 629-640, [8.491]
• Nelson, P. J. , Rees, A. J., Griffin, M. D., Hughes, J., Kurts, C., Duffield, J. (2012): The renal mononuclear phagocytic system. Journal of Americal Society of Nephrology, 23, 194-203, [8.491]
• Hucke, S. , Flossdorf, J., Grutzke, B., Dunay, I. R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brustle, O., Kurts, C., Klockgether, T., Neumann, H., Prinz, M., Wiendl, H., Knolle, P., Klotz, L. (2012): Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor gamma. Brain-Journal of Neurology, 135 (5), 1586-1605, [10.103]
• Huang, L. R. , Gabel, Y. A., Graf, S., Arzberger, S., Kurts, C., Heikenwalder, M., Knolle, P. A., Protzer, U. (2012): Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. Gastroenterology, 142, 1447-1450, [18.187]
• Hochst, B. , Schildberg, F. A., Bottcher, J., Metzger, C., Huss, S., Turler, A., Overhaus, M., Knoblich, A., Schneider, B., Pantelis, D., Kurts, C., Kalff, J., Knolle, P., Diehl, L. (2012): Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance towards circulating carcinoembryonic antigen in mice. Hepatology, 56(5), 1924-33, [11.711]
• Gotot, J. , Gottschalk, C., Leopold, S., Knolle, P. A., Yagita, H., Kurts, C., Ludwig-Portugall, I. (2012): Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo. Proceedings of the National Academy of Sciences of the USA, 109 (26), 10468-10473, [9.423]
• Tittel, A. P. , Heuser, C., Ohliger, C., Knolle, P. A., Engel, D. R., Kurts, C. (2011): Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol, 22, 1435-1441,
• Teteris, S. A. , Engel, D. R., Kurts, C. (2011): Homeostatic and pathogenic role of renal dendritic cells. Kidney International, 80 (2), 139-145, [7.683]
• Tacke, F. , Kurts, C. (2011): Infiltrating monocytes versus resident Kupffer cells: do alternatively activated macrophages need to be targeted alternatively?. Hepatology, 54 (6), 2267-2270, [11.711]
• Schildberg, F. A. , Wojtalla, A., Siegmund, S. V., Endl, E., Diehl, L., Abdullah, Z., Kurts, C., Knolle, P. A. (2011): Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology, 54 (1), 262-272, [11.711]
• Ooi, J. D. , Snelgrove, S. L., Engel, D. R., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K. M., Hickey, M. J., Holdsworth, S. R., Kurts, C., Kitching, A. R. (2011): Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney International, 79 (9), 977-986, [7.683]
• Kurts, C. (2011): Constructing an immune system for glomerulonephritis studies. Journal of American Society Nephrology, 22 (3), 398-399, [8.491]
• Hochheiser, K. , Engel, D. R., Hammerich, L., Heymann, F., Knolle, P. A., Panzer, U., Kurts, C. (2011): Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria. Journal of American Society of Nephrology, 22 (8), 1435-1441, [8.491]
• Gotot, J. , Leopold, S., Knolle, P. A., Yagita, H., Kurts, C., Ludwig-Portugall, I. (2011): Direct PD-1-mediated suppression of autoreactive B cells by regulatory T cells.. Proc. Natl. Acad. Sci. USA,
• Stabenow, D. , Frings, M., Truck, C., Gartner, K., Forster, I., Kurts, C., Tuting, T., Odenthal, M., Dienes, H. P., Cederbrant, K., Protzer, U., Knolle, P. A. (2010): Bioluminescence imaging allows measuring CD8 T cell function in the liver.. Hepatology, 51, 1430-1437, [11.711]
• Semmling, V. , Lukacs-Kornek, V., Thaiss, C. A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D. I., Savage, P. B., Knolle, P. A., Kolanus, W., Forster, I., Kurts, C. (2010): Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nature Immunology, 11, 313-320, [19.381]
• Schurich, A. , Berg, M., Stabenow, D., Bottcher, J., Kern, M., Schild, H. J., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., Limmer, A., Knolle, P. A. (2010): Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells. J Immunol, 184, 4107-4114,
• Panzer, U. , Kurts, C. (2010): T cell cross-talk with kidney dendritic cells in glomerulonephritis. Journal of Molecular Medicine (Berl), 88 (1), 19-26, [4.855]
• Kurts, C. , Robinson, B. W., Knolle, P. A. (2010): Cross-priming in health and disease. Nature Reviews Immunology, 10, 403-414, [39.416]
• Kurts, C. (2010): Dendritic cells erase bad memory. European Journal of Immunology, 40 (7), 1870-1872, [4.179]
• Kern, M. , Popov, A., Kurts, C., Schultze, J. L., Knolle, P. A. (2010): Taking off the brakes: T cell immunity in the liver. Trends in Immunology, 3 (8), 311-317, [11.433]
• Engel, D. R. , Koscielny, A., Wehner, S., Maurer, J., Schiwon, M., Franken, L., Schumak, B., Limmer, A., Sparwasser, T., Hirner, A., Knolle, P. A., Kalff, J. C., Kurts, C. (2010): T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nature Medicine, 16 (12), 1407-1413, [30.357]
• Burgdorf, S. , Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P. A., Kurts, C. (2010): Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proceedings of the National Acadedemy of Sciences in the U S A, 107 (13), 48-49, [9.423]
• Lutz, M. B. , Kurts, C. (2009): Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells.. Eur J Immunol, 39, 2325-2330, [4.179]
• Paust, H. J. , Turner, J. E., Steinmetz, O. M., Peters, A., Heymann, F., Holscher, C., Wolf, G., Kurts, C., Mittrucker, H. W., Stahl, R. A., Panzer, U. (2009): The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol, 20, 969-979, [4.657]
• Klotz, L. , Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J., Hucke, S., Alferink, J., Nowak, N., Beyer, M., Mayer, G., Langhans, B., Klockgether, T., Waisman, A., Eberl, G., Schultze, J., Famulok, M., Kolanus, W., Glass, C., Kurts, C., Knolle, P. A. (2009): The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med, 206, 2079-2089, [1.287]
• Heymann, F. , Meyer-Schwesinger, C., Hamilton-Williams, E. E., Hammerich, L., Panzer, U., Kaden, S., Quaggin, S. E., Floege, J., Grone, H. J., Kurts, C. (2009): Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest, 119, 1286-1297, [12.575]