P18 Prof. Dr. Trebicka
Angiotensin vermittelte hepatische Fibrogenese und portale Hypertension: Rezeptor-Regulation und intrazelluläre Signalkaskaden

Das Ziel dieses Projektes ist die Reduktion der Leberfibrose und portale Hypertension durch die Modulation des Renin-Angiotensin-Systems (RAS) und ihre intrazelluläre Signalkaskaden. Es wird die Rolle weiterer Mitglieder des RAS untersucht, nämlich von dem Enzym Neprilysin (NEP), und der Rezeptoren AT2R und MrgD in der experimentellen Leberfibrose. Dabei werden genetisch modifizierte Mäuse defizient für NEP, AT2R and MrgD, sowie die kontinierliche Stimulation und Hemmung von NEP, AT2R und MrgD-Rezeptor genutzt. Nach Induktion der Leberfibrose, wird die Entwicklung der Fibrose und portale Hypertension in vitro und in vivo untersucht, mit besonderem Augenmerk auf die Signalmoleküle um neue Therapien zu entwickeln. [...]

Publikationen

• Wirtz T. H. , Reuken P. A., Jansen C., Fischer P., Bergmann I., Backhaus C., Emontzpohl C., Reißing J., Brandt E. F., Koenen T. M., Schneider K. M., Schierwagen R., Brol M. J., Chang J., Zimmermann H. W., Köse-Vogel N., Eggermann T., Kurth I., Stoppe C., Bucala R., Bernhagen J., Praktiknjo M., Stallmach A., Trautwein C., Trebicka J., Bruns T., Berres M.-L. (2021): Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis. JHEP Reports, in press,
• Trebicka J. , Amoros A., Pitarch C., Titos E., Alcaraz-Quiles J., Schierwagen R., Deulofeu C., Fernandez-Gomez J., Piano S., Caraceni P., Oettl K., Sola E., Laleman W., McNaughtan J., Mookerjee R. P., Coenraad M. J., Welzel T., Steib C., Garcia R., Gustot T., Rodriguez Gandia M. A., Bañares R., Albillos A., Zeuzem S., Vargas V., Saliba F., Nevens F., Alessandria C., de Gottardi A., Zoller H., Ginès P., Sauerbruch T., Gerbes A., Stauber R. E., Bernardi M., Angeli P., Pavesi M., Moreau R., Clària J., Jalan R., Arroyo V. (2019): Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis. Front Immunol, 10, 476, [4.716]
• Trebicka J. , Bastgen D., Byrtus J., Praktiknjo M., Terstiegen S., Meyer C., Thomas D., Fimmers R., Treitl M., Euringer W., Sauerbruch T., Rössle M. (2019): Smaller-Diameter Covered Transjugular Intrahepatic Portosystemic Shunt Stents Are Associated With Increased Survival. Clin Gastroenterol Hepatol, 17(13), 2793-2799, [7.958]
• Torner M. , Mangal A., Scharnagl H., Jansen C., Praktiknjo M., Queck A., Gu W., Schierwagen R., Lehmann J., Uschner F. E., Graf C., Strassburg C. P., Fernandez J., Stojakovic T., Woitas R., Trebicka J. (2019): Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS. Liver Int, [5.542]
• Stratmann K. , Fitting D., Zeuzem S., Bojunga J., Trebicka J., Friedrich-Rust M., Dultz G. (2019): Establishing an indwelling peritoneal catheter as a standard procedure for hospitalized patients with ascites: Retrospective data on feasibility, effectiveness and safety. United European Gastroenterol J, 7(5), 673-681, [3.477]
• Stickel F. , Lutz P., Buch S., Nischalke H. D., Silva I., Rausch V., Fischer J., Weiss K. H., Gotthardt D., Rosendahl J., Marot A., Elamly M., Krawczyk M., Casper M., Lammert F., Buckley T. W., McQuillin A., Spengler U., Eyer F., Vogel A., Marhenke S., von Felden J., Wege H., Sharma R,. Atkinson S., Franke A., Nehring S., Moser V., Schafmayer C., Spahr L., Lackner C., Stauber R. E., Canbay A., Link A., Valenti L., Grove J. I., Aithal G. P., Marquardt J. U., Fateen W., Zopf S., Dufour J. F., Trebicka J., Datz C., Deltenre P., Mueller S., Berg T., Hampe J., Morgan M. Y. (2019): Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers. Hepatology, [14.079]
• Roedig H. , Damiescu R., Zeng-Brouwers J., Kutija I., Trebicka J., Wygrecka M., Schaefer L. (2019): Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development. Semin Cancer Biol, [10.198]
• Rao T. N. , Hansen N., Hilfiker J., Rai S., Majewska J. M., Leković D., Gezer D., Andina N., Galli S., Cassel T., Geier F., Delezie J., Nienhold R., Hao-Shen H., Beisel C., Di Palma S., Dimeloe S., Trebicka J., Wolf D., Gassmann M., Fan T. W., Lane A. N., Handschin C., Dirnhofer S., Kröger N., Hess C., Radimerski T., Koschmieder S., Čokić V. P., Skoda R. C. (2019): JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134(21), 1832-1846, [16.562]
• Queck A. , Thomas D., Jansen C., Schreiber Y., Rüschenbaum S., Praktiknjo M., Schwarzkopf K. M., Mücke M. M., Schierwagen R., Uschner F. E., Meyer C., Clària J., Zeuzem S., Geisslinger G., Trebicka J., Lange C. M. (2019): Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. PLoS One, 14(10), e0222840, [2.776]
• Queck A. , Carnevale R., Uschner F. E., Schierwagen R., Klein S., Jansen C., Meyer C., Praktiknjo M., Thomas D., Strassburg C., Zeuzem S., Violi F., Trebicka J. (2019): Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS. Gut, [17.160]
• Praktiknjo M. , Djayadi N., Mohr R., Schierwagen R., Bischoff J., Dold L., Pohlmann A., Schwarze-Zander C., Wasmuth J. C., Boesecke C., Rockstroh J. K., Trebicka J. (2019): Fibroblast growth factor 21 is independently associated with severe hepatic steatosis in non-obese HIVinfected patients. Liver Int, 39(8), 1514-1520, [5.542]
• Praktiknjo M. , Clees C., Pigliacelli A., Fischer S., Jansen C., Lehmann J., Pohlmann A., Lattanzi B., Krabbe V. K., Strassburg C. P., Arroyo V., Merli M., Meyer C., Trebicka J. (2019): Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt. Clin Transl Gastroenterol, 10(4), e00025, [4.621]
• Pose E. , Trebicka J., Mookerjee R. P., Angeli P., Ginès P. (2019): Statins: Old drugs as new therapy for liver diseases?. J Hepatol, 70(1), 194-202, [18.946]
• Pose E. , Napoleone L., Amin A., Campion D., Jimenez C., Piano S., Roux O., Uschner F. E., de Wit K., Zaccherini G., Alessandria C., Angeli P., Bernardi M., Beuers U., Caraceni P., Durand F., Mookerjee R. P., Trebicka J., Vargas V., Andrade R. J., Carol M., Pich J., Ferrero J., Domenech G., Llopis M., Torres F., Kamath P. S., Abraldes J. G., Solà E., Ginès P. (2019): Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPESAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Gastroenterol Hepatol, [12.865]
• Luetkens J. A. , Klein S., Träber F., Block W., Schmeel F. C., Sprinkart A. M., Kuetting D. L. R., Uschner F. E., Schierwagen R., Thomas D., Trebicka J., Kukuk G.M. (2019): Quantification of liver fibrosis: extracellular volume fraction using an MRI bolus-only technique in a rat animal model. Eur Radiol Exp, 3(1), 22, [4.027]
• Malin J. J. , Boesecke C., Schwarze-Zander C., Wasmuth J. C., Schlabe S., Trebicka J., Spengler U., Llibre J. M., Jou T., Vasylyev M., Clotet B., Rockstroh J. K. (2019): Liver stiffness regression after successful Hepatitis C treatment is independent of HIV coinfection. HIV Med, 20(3), 230-236, [3.734]
• Lehmann J. , Praktiknjo M., Nielsen M. J., Schierwagen R., Meyer C., Thomas D., Violi F., Strassburg C. P., Bendtsen F., Møller S., Krag A., Karsdal M. A., Leeming D. J., Trebicka J. (2019): Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis. Liver Int, 39(5), 885-893, [5.542]
• Klein S. , Kleine C. E., Pieper A., Granzow M., Gautsch S., Himmit M., Kahrmann K., Schierwagen R., Uschner F. E., Magdaleno F., Naoum M. E., Kristiansen G., Walther T., Bader M., Sauerbruch T., Trebicka J. (2019): TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor. Sci Rep, 9, (1), 11598, [4.011]
• Klein S. , Frohn F., Magdaleno F., Reker-Smit C., Schierwagen R., Schierwagen I., Uschner F. E., Fürst D. O., Djudjaj S., Boor P., Poelstra K., Beljaars L., Trebicka J. (2019): Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces fibrogenesis and portal pressure in cirrhotic rats with increased renal perfusion. Sci Rep, 9, 2256, [4.011]
• Klein L. M. , Chang J., Gu W., Manekeller S., Jansen C., Lingohr P., Praktiknjo M., Kalf J. C., Schulz M., Spengler U., Strassburg C., Cardenas A., Arroyo V., Trebicka J. (2019): The development and outcome of acute-on-chronic liver failure after surgical interventions. Liver Transpl, [5.583]
• Jansen C. , Trebicka J. (2019): Editorial: diastolic dysfunction seems not to be decisive for survival after transjugular intrahepatic portosystemic stent-shunt. Aliment Pharmacol Ther, 49(8), 1101-1102, [7.357]
• Jansen C. , Schröder A., Schueler R., Lehmann J., Praktiknjo M., Uschner F. E., Schierwagen R., Thomas D., Monteiro S., Nickenig G., Strassburg C. P., Meyer C., Arroyo V., Hammerstingl C., Trebicka J. (2019): Left Ventricular Longitudinal Contractility Predicts Acute-on-Chronic Liver Failure Development and Mortality After Transjugular Intrahepatic Portosystemic Shunt. Hepatol Commun, 3(3), 340-347, [0.800]
• Jansen C , Chatterjee DA, Thomsen KL, Al-Kassou B, Sawhney R, Jones H, Gallego-Leon A, Lehmann J, Pohlmann A., Nickenig G., Strassburg C. P., Andrié R., Jalan R., Linhart M., Trebicka J., Mookerjee R. P. (2019): Significant reduction in heart rate variability is a feature of acute decompensation of cirrhosis and predicts 90-day mortality. Aliment Pharmacol Ther, 50(5), 568-579, [7.357]
• Hernández-Gea V. , Procopet B., Giráldez Á., Amitrano L., Villanueva C., Thabut D., Ibañez-Samaniego L., Silva-Junior G., Martinez J., Genescà J., Bureau C., Trebicka J., Llop E., Laleman W., Palazon J. M., Castellote J., Rodrigues S., Gluud L. L., Noronha Ferreira C., Barcelo R., Cañete N., Rodríguez M., Ferlitsch A., Mundi J. L., Gronbaek H., Hernández-Guerra M., Sassatelli R., Dell'Era A., Senzolo M., Abraldes J. G., Romero-Gómez M., Zipprich A., Casas M., Masnou H., Primignani M., Krag A., Nevens F., Calleja J. L., Jansen C., Robic M. A., Conejo I., Catalina M. V., Albillos A., Rudler M., Alvarado E., Guardascione M. A., Tantau M., Bosch J., Torres F., Garcia-Pagán J. C., International Variceal Bleeding Observational Study Group and Baveno Cooperation (2019): Preemptive-TIPS Improves Outcome in High-Risk Variceal Bleeding: An Observational Study. Hepatology, 69(1), 282-293, [14.079]
• Gonzalez-Carmona M. A. , Bolch M., Jansen C., Vogt A., Sampels M., Mohr R. U., van Beekum K., Mahn R., Praktiknjo M., Nattermann J., Trebicka J., Branchi V., Matthaei H., Manekeller S., Kalff J. C., Strassburg C. P., Weismüller T. J. (2019): Combined photodynamic therapy with systemic chemotherapy for unresectable cholangiocarcinoma. Aliment Pharmacol Ther, 49(4), 437-447, [7.357]
• Gerbes A. L. , Labenz J., Appenrodt B., Dollinger M., Gundling F., Gülberg V., Holstege A., Lynen-Jansen P., Steib C. J., Trebicka J., Wiest R., Zipprich A., Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV), Deutsche Gesellschaft für Innere Medizin e. V. (DGIM), Deutsche Gesellschaft für Infektiologie e. V. (DGI), Deutsche Gesellschaft für Pathologie e. V./Bundesverband deutscher Pathologen e. V. (DGP/BDP), Deutsche Röntgengesellschaft e. V. (DRG), Deutsche Gesellschaft für Interventionelle Radiologie und minimal-invasive Therapie (DeGIR), Deutsche Gesellschaft für Nephrologie (DGFN), Deutsche Gesellschaft für Ultraschall in der Medizin (DEGUM), Deutsche Gesellschaft für Neurologie e. V. (DGN), Deutsche Gesellschaft für Ernährungsmedizin e. V. (DGEM), Lebertransplantierte Deutschland e. V., Collaborators (2019): Updated S2k-Guideline "Complications of liver cirrhosis". German Society of Gastroenterology (DGVS). Zeitschrift für Gastroenterologie, 57(5), 611-680, [1.612]
• Fernández J. , Angeli P., Trebicka J., Merli M., Gustot T., Alessandria C., Aagaard N. K., de Gottardi A., Welzel T. M., Gerbes A., Soriano G., Vargas V., Albillos A., Salerno F., Durand F., Bañares R., Stauber R., Prado V., Arteaga M., Hernández-Tejero M., Aziz F., Morando F., Jansen C., Lattanzi B., Moreno C., Campion D., Gronbaek H., Garcia R., Sánchez C., García E., Amorós A., Pavesi M., Clària J., Moreau R., Arroyo V. (2019): Efficacy of Albumin Treatment for Patients with Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis. Clin Gastroenterol Hepatol, [7.958]
• Fernández J. , Clària J., Amorós A., Aguilar F., Castro M., Casulleras M., Acevedo J., Duran-Güell M., Nuñez L., Costa M., Torres M., Horrillo R., Ruiz-Del-Árbol L., Villanueva C., Prado V., Arteaga M., Trebicka J., Angeli P., Merli M., Alessandria C., Aagaard N. K., Soriano G., Durand F., Gerbes A., Gustot T., Welzel T. M., Salerno F., Bañares R., Vargas V., Albillos A., Silva A., Morales-Ruiz M., García-Pagán J. C., Pavesi M., Jalan R., Bernardi M., Moreau R., Páez A., Arroyo V. (2019): Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis. Gastroenterology, 157(1), 149-162, [20.773]
• Fernández J , Prado V, Trebicka J, Amoros A, Gustot T, Wiest R, Deulofeu C, Garcia E, Acevedo J, Fuhrmann V, Durand F, Sánchez C, Papp M, Caraceni P, Vargas V, Bañares R, Piano S, Janicko M, Albillos A, Alessandria C, Soriano G, Welzel TM, Laleman W, Gerbes A, De Gottardi A, Merli M, Coenraad M, Saliba F, Pavesi M, Jalan R, Ginès P, Angeli P, Arroyo V; European Foundation for the Study of Chronic Liver Failure (EF-Clif) (2019): Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe. J Hepatol, 70(3), 398-411, [18.946]
• Faron A. , Pieper C. C., Schmeel F. C., Sprinkart A. M., Kuetting D. L. R., Fimmers R., Trebicka J., Schild H. H., Meyer C., Thomas D., Luetkens J. A. (2019): Fat-free muscle area measured by magnetic resonance imaging predicts overall survival of patients undergoing radioembolization of colorectal cancer liver metastases. Eur Radiol, 29(9), 4709-4717, [4.027]
• Elkrief L. , Ferrusquia-Acosta J., Payancé A., Moga L., Tellez L., Praktiknjo M., Procopet B., Farcau O., De Lédinghen V., Yuldashev R., Tabchouri N., Barbier L., Dumortier J., Menahem B., Magaz M., Hernández-Gea V., Albillos A., Trebicka J., Spahr L., De Gottardi A., Plessier A., Valla D., Rubbia-Brandt L., Toso C., Bureau C., Garcia-Pagan J. C., Rautou P. E., for VALDIG, an EASL consortium (2019): Abdominal Surgery in Patients With Idiopathic Noncirrhotic Portal Hypertension: A Multicenter Retrospective Study. Hepatology, 70(3), 911-924, [14.079]
• Dold L. , Nielsen M. J., Praktiknjo M., Schwarze-Zander C., Boesecke C., Schierwagen R., Mohr R., Wasmuth J. C., Jansen C., Bischoff J., Rockstroh J. K., Karsdal M. A., Spengler U., Trebicka J., Leeming D. J. (2019): Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART. PLoS One, 14(7), e0219526, [2.776]
• De Gottardi A. , Rautou P. E., Schouten J., Rubbia-Brandt L., Leebeek F., Trebicka J., Murad S. D., Vilgrain V., Hernandez-Gea V., Nery F., Plessier A., Berzigotti A., Bioulac-Sage P., Primignani M., Semela D., Elkrief L., Bedossa P., Valla D., Garcia-Pagan J. C., VALDIG group (2019): Porto-sinusoidal vascular disease: proposal and description of a novel entity. Lancet Gastroenterol Hepatol, 4(5), 399-411, [12.865]
• Cullaro G. , Sharma R., Trebicka J., Cardenas A., Verna E. C. (2019): ”.” [5.583] (2019): Precipitants of Acute-On-Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes. Liver Transpl, [5.583]
• Clària J. , Moreau R., Fenaille F., Amorós A., Junot C., Gronbaek H., Coenraad M. J., Pruvost A., Ghettas A., Chu-Van E., López-Vicario C., Oettl K., Caraceni P., Alessandria C., Trebicka J., Pavesi M., Deulofeu C., Albillos A., Gustot T., Welzel T. M., Fernández J., Stauber R. E., Saliba F., Butin N., Colsch B., Moreno C., Durand F., Nevens F., Bañares R., Benten D., Ginès P., Gerbes A., Jalan R., Angeli P., Bernardi M., Arroyo V.; CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif) (2019): Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis. Hepatology, 69(4), 1686-1701, [14.079]
• Casey S. , Schierwagen R., Mak K. Y., Klein S., Uschner F., Jansen C., Praktiknjo M., Meyer C., Thomas D., Herath C., Jones R., Trebicka J., Angus P. (2019): Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation. J Clin Med, 8(4), E419, [5.583]
• Brol M. J. , Rösch F., Schierwagen R., Magdaleno F., Uschner F. E., Manekeller S., Queck A., Schwarzkopf K., Odenthal M., Drebber U., Thiele M., Lingohr P., Plamper A., Kristiansen G., Lotersztajn S., Krag A., Klein S., Rheinwalt K. P., Trebicka J. (2019): Combination of CCl with alcoholic and metabolic injuries mimics human liver fibrosis. Am J Physiol Gastrointest Liver Physiol, 317(2), G182-G194, [3.468]
• Asphaug L. , Thiele M., Krag A., Melberg H. O.; GALAXY consortium (2019): Cost-effectiveness of non-invasive screening for alcohol-related liver fibrosis. Hepatology, 2019, [14.079]
• Alvarez-Silva C. , Schierwagen R., Pohlmann A., Magdaleno F., Uschner F. E., Ryan P., Vehreschild M. J. G. T., Claria J., Latz E., Lelouvier B., Arumugam M., Trebicka J. (2019): Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis. Front Immunol, 10, 69, [4.716]
• Abraldes J. G. , Trebicka J., Chalasani N., D'Amico G., Rockey D. C., Shah V. H., Bosch J., Garcia-Tsao G. (2019): Prioritization of Therapeutic Targets and Trial Design in Cirrhotic Portal Hypertension. Hepatology, 69(3), 1287-1299, [14.079]
• Welz M. , Eickhoff S., Abdullah Z., Trebicka J., Gartlan K. H., Spicer J. A., Demetris A. J., Akhlaghi H., Anton M., Manske K., Zehn D., Nieswandt B., Kurts C., Trapani J. A., Knolle P., Wohlleber D., Kastenmüller W. (2018): Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis. Nat Commun, 9(1), 4805, [11.878]
• Uschner F. E. , Schueller F., Nikolova I., Klein S., Schierwagen R., Magdaleno F., Gröschl S., Loosen S., Ritz T., Roderburg C., Vucur M., Kristiansen G., Lammers T., Luedde T., Trebicka J. (2018): The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension. Oncotarget, 9(90), 36220-36237, [5.168]
• Trebicka J. , Reiberger T., Laleman W. (2018): Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure. Visc Med, 34(4), 270-275, [2.290]
• Trebicka J. (2018): Does Transjugular Intrahepatic Portosystemic Shunt Stent Differentially Improve Survival in a Subset of Cirrhotic Patients?. Semin Liver Dis, 38(1), 87-96, [4.167]
• Simón-Talero M. , Roccarina D., Martínez J., Lampichler K., Baiges A., Low G., Llop E., Praktiknjo M., Maurer M. H., Zipprich A., Triolo M., Vangrinsven G., Garcia-Martinez R., Dam A., Majumdar A., Picón C., Toth D., Darnell A., Abraldes J. G., Lopez M., Kukuk G., Krag A., Bañares R., Laleman W., La Mura V., Ripoll C., Berzigotti A., Trebicka J., Calleja J. L., Tandon P., Hernandez-Gea V., Reiberger T., Albillos A., Tsochatzis E. A., Augustin S., Genescà J., Baveno VI-SPSS group from the Baveno Cooperation (2018): Association Between Portosystemic Shunts and Increased Complications and Mortality in Patients With Cirrhosis. Gastroenterology, 154(6), 1694-1705, [20.773]
• Schwabl P. , Brusilovskaya K., Supper P., Bauer D., Königshofer P., Riedl F., Hayden H., Fuchs C. D., Stift J., Oberhuber G., Aschauer S., Bonderman D., Gnad T., Pfeifer A., Uschner F. E., Trebicka J., Rohr-Udilova N., Podesser B. K., Peck-Radosavljevic M., Trauner M., Reiberger T. (2018): The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats. Sci Rep, 8(1), 9372, [4.011]
• Schierwagen R. , Alvarez-Silva C., Madsen M. S. A., Kolbe C. C., Meyer C., Thomas D., Uschner F. E., Magdaleno F., Jansen C., Pohlmann A., Praktiknjo M., Hischebeth G. T., Molitor E., Latz E., Lelouvier B., Trebicka J., Arumugam M. (2018): Circulating microbiome in blood of different circulatory compartments. Gut, gutjnl-2018, 316227, [17.160]
• Sauerbruch T. , Schierwagen R., Trebicka J. (2018): Managing portal hypertension in patients with liver cirrhosis. F1000Res, 7, Rev-533,
• Ruiz-Margáin A. , Pohlmann A., Ryan P., Schierwagen R., Chi-Cervera L. A., Jansen C., Mendez-Guerrero O., Flores-García N. C., Lehmann J., Torre A., Macías-Rodríguez R. U., Trebicka J. (2018): Fibroblast growth factor 21 is an early predictor of acute-on-chronic liver failure in critically ill patients with cirrhosis. Liver Transpl, 24(5), 595-605, [5.583]
• Praktiknjo M. , Lehmann J., Nielsen M. J., Schierwagen R., Uschner F. E., Meyer C., Thomas D., Strassburg C. P., Bendtsen F., Møller S., Krag A., Karsdal M. A., Leeming D. J., Trebicka J. (2018): Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis. Hepatol Commun, 2(2), 211-222, [0.800]
• Praktiknjo M. , Krabbe V., Pohlmann A., Sampels M., Jansen C., Meyer C., Strassburg C. P., Trebicka J., Gonzalez Carmona M.A. (2018): Evolution of nodule stiffness might predict response to local ablative therapy: A series of patients with hepatocellular carcinoma. PLoS One, 13(2), e0192897, [2.776]
• Praktiknjo M. , Book M., Luetkens J., Pohlmann A., Meyer C., Thomas D., Jansen C., Feist A., Chang J., Grimm J., Lehmann J., Strassburg C. P., Abraldes J. G., Kukuk G., Trebicka J. (2018): Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis. Hepatology, 67(3), 1014-1026, [14.079]
• Mohr R. , Boesecke C., Dold L., Schierwagen R., Schwarze-Zander C., Wasmuth J. C., Weisensee I., Rockstroh J. K., Trebicka J. (2018): Return-to-health effect of modern combined antiretroviral therapy potentially predisposes HIV patients to hepatic steatosis. Medicine (Baltimore), 97(17), e0462, [1.870]
• Magdaleno F. , Schierwagen R., Uschner F. E., Trebicka J. (2018): Tipping" extracellular matrix remodeling towards regression of liver fibrosis: novel concepts. Minerva Gastroenterol Dietol, 64(1), 51-61, [0.460]
• Luetkens J. A. , Klein S., Traeber F., Schmeel F. C., Sprinkart A. M., Kuetting D. L. R, Block W., Hittatiya K., Uschner F. E., Schierwagen R., Gieseke J., Schild H. H., Trebicka J., Kukuk G. M. (2018): Quantitative liver MRI including extracellular volume fraction for non-invasive quantification of liver fibrosis: a prospective proof-of-concept study. Gut, 67(3), 593-594, [17.160]
• Luetkens J. A. , Klein S., Träber F., Schmeel F. C., Sprinkart A. M., Kuetting D. L. R., Block W., Uschner F. E., Schierwagen R., Hittatiya K., Kristiansen G., Gieseke J., Schild H. H., Trebicka J., Kukuk G. M. (2018): Quantification of Liver Fibrosis at T1 and T2 Mapping with Extracellular Volume Fraction MRI: Preclinical Results. Radiology, 288(3), 748-754, [7.469]
• Lehmann J. M. , Claus K., Jansen C., Pohlmann A., Schierwagen R., Meyer C., Thomas D., Manekeller S., Claria J., Strassburg C. P., Trautwein C., Wasmuth H. E., Berres M. L., Trebicka J. (2018): Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality. Liver Int, 38(5), 875-884, [5.542]
• Lange C. M. , Bechstein W. O., Berg T., Engelmann C., Bruns T., Canbay A., Moreau R., Trebicka J. (2018): Acute-on-Chronic Liver Failure. Visc Med, 34(4), 296-300, [2.290]
• Laleman W. , Claria J., Van der Merwe S., Moreau R., Trebicka J. (2018): Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough. Can J Gastroenterol Hepatol, , 1027152, [1.714]
• Jansen C. , Möller P., Meyer C., Kolbe C. C., Bogs C., Pohlmann A., Schierwagen R., Praktiknjo M., Abdullah Z., Lehmann J., Thomas D., Strassburg C. P., Latz E., Mueller S., Rössle M., Trebicka J. (2018): Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality. Hepatology, 67(4), 1472-1484, [14.079]
• Jansen C. , Cox A., Schueler R., Schneider M., Lehmann J., Praktiknjo M., Pohlmann A., Chang J., Manekeller S., Nickenig G., Berlakovich G., Strassburg C. P., Hammerstingl C., Staufer K., Trebicka J. (2018): Increased myocardial contractility identifies patients with decompensated cirrhosis requiring liver transplantation. Liver Transpl, 24(1), 15-25, [5.583]
• Jansen C. , Al-Kassou B., Lehmann J., Pohlmann A., Chang J., Praktiknjo M., Nickenig G., Strassburg C. P., Schrickel J. W., Andrié R., Linhart M., Trebicka J. (2018): Severe abnormal Heart Rate Turbulence Onset is associated with deterioration of liver cirrhosis. PLoS One, 13(4), e0195631, [2.776]
• Herrmann E. , de Lédinghen V., Cassinotto C., Chu W. C., Leung V. Y., Ferraioli G., Filice C., Castera L., Vilgrain V., Ronot M., Dumortier J., Guibal A., Pol S., Trebicka J., Jansen C., Strassburg C., Zheng R., Zheng J., Francque S., Vanwolleghem T., Vonghia L., Manesis E. K., Zoumpoulis P., Sporea I., Thiele M., Krag A., Cohen-Bacrie C., Criton A., Gay J., Deffieux T., Friedrich-Rust M. (2018): Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis. Hepatology, 67(1), 260-272, [14.079]
• Beiert T. , Knappe V., Tiyerili V., Stöckigt F., Effelsberg V., Linhart M., Steinmetz M., Klein S., Schierwagen R., Trebicka J., Roell W., Nickenig G., Schrickel J. W., Andrié R. P. (2018): Chronic lower-dose relaxin administration protects from arrhythmia in experimental myocardial infarction due to anti-inflammatory and anti-fibrotic properties. Int J Cardiol, 250, 21-28, [4.034]
• Audebert C. , Peeters G., Segers P., Laleman W., Monbaliu D., Korf H., Trebicka J., Vignon-Clementel I. E., Debbaut C. (2018): Closed-Loop Lumped Parameter Modeling of Hemodynamics During Cirrhogenesis in Rats. IEEE Trans Biomed Eng, 65(10), 2311-2322, [4.491]
• Anadol E. , Lust K., Boesecke C., Schwarze-Zander C., Mohr R., Wasmuth J. C., Rockstroh J. K., Trebicka J. (2018): Exposure to previous cART is associated with significant liver fibrosis and cirrhosis in human immunodeficiency virus-infected patients. PLoS One, 13(1), e0191118, [2.776]
• De Gottardi A , Trebicka J, Klinger C, Plessier A, Seijo S, Terziroli B, Magenta L, Semela D, Buscarini E, Langlet P, Görtzen J, Puente A, Müllhaupt B, Navascuès C, Nery F, Deltenre P, Turon F, Engelmann C, Arya R, Caca K, Peck-Radosavljevic M, Leebeek FWG, Valla D, Garcia-Pagan JC (2017): Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis.. Liver International, 37(5), 694–699, [4.470]
• Görtzen J. , Trebicka J. (2017): Rho-kinase inhibition is beneficial in fibrosis. Hepatology, 65(5), 1780–1781, [11.711]
• Jansen C , Bogs C, Verlinden W, Thiele M, Möller P, Görtzen J, Lehmann J, Vanwolleghem T, Vonghia L, Praktiknjo M, Chang J, Krag A, Strassburg CP, Francque S, Trebicka J. (2017): Shear-wave elastography of the liver and spleen identifies clinically significant portal hypertension: A prospective multicentre study. Liver International, 37(3), 396-405, [4.470]
• Magdaleno F , Trebicka J. (2017): Selective LOXL2 inhibition: potent antifibrotic effects in ongoing fibrosis and fibrosis regression. Gut, [14.921]
• Trebicka J , Gluud LL (2017): Reply to "Adding embolization to TIPS implantation: A better therapy to control bleeding from ectopic varices?. Journal of Hepatology, [10.590]
• Praktiknjo M , Strassburg CP, Trebicka J. (2017): Recent thrombosis of splanchnic veins: Two case reports of catheter-assisted local thrombolysis and thrombus aspiration. Der Internist, [0.336]
• Schierwagen R , Uschner FE, Magdaleno F, Klein S, Trebicka J. (2017): Rationale for the use of statins in liver disease. American Journal of Physiology Gastrointestinal and Liver Physiology, 312, 407-412, [3.297]
• Pieper CC , Jansen C, Meyer C, Nadal J, Lehmann J, Schild HH, Trebicka J, Thomas D. (2017): Prospective Evaluation of Passive Expansion of Partially Dilated Transjugular Intrahepatic Portosystemic Shunt Stent Grafts-A Three-Dimensional Sonography Study. Journal of Vascular and Interventional Radiology, 28(1), 117-125 [2.570], [2.570]
• Lutz P , M Haimid M, Pohlmann A, Lehmann J, Jansen C, Schierwagen R, Klein S, Strassburg CP, Spengler U, Trebicka J. (2017): MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis. Scientific Reports, 7, 40556, [5.228]
• Schwab S , Lehmann J, Lutz P, Jansen C, Appenrodt B, Lammert F, Strassburg CP, Spengler U, Nischalke HD, Trebicka J. (2017): Influence of genetic variations in the SOD1 gene on the development of ascites and spontaneous bacterial peritonitis in decompensated liver cirrhosis.. European Journal of Gastroenterology & Hepatology, 29(7), 800-804, [2.093]
• Kjærgaard M , Thiele M, Jansen C, Stæhr Madsen B, Görtzen J, Strassburg C, Trebicka J, Krag A. (2017): High risk of misinterpreting liver and spleen stiffness using 2D shear-wave and transient elastography after a moderate or high calorie meal. PLoS One, 12 (4), [3.057]
• Trebicka J. (2017): Emergency TIPS in a Child-Pugh B patient: When does the window of opportunity open and close?. Journal of Hepatology, 66(2), 442–450, [10.590]
• Herrmann E. , de Lédinghen V, Cassinotto C, Chu WC, Leung VY, Ferraioli G, Filice C, Castera L, Vilgrain V, Ronot M, Dumortier J, Guibal A, Pol S, Trebicka J, Jansen C, Strassburg C, Zheng R, Zheng J, Francque S, Vanwolleghem T, Vonghia L, Manesis EK, Zoumpoulis P, Sporea I, Thiele M, Krag A, Cohen-Bacrie C, Criton A, Gay J, Deffieux T, Friedrich-Rust M. (2017): Assessment of biopsy-proven liver fibrosis by 2D-shear wave elastography: An individual patient data based meta-analysis. Hepatology, [11.711]
• Berres M.L. , Lehmann J, Jansen C, Görtzen J, Meyer C, Thomas D, Zimmermann HW, Kroy D, Schumacher F, Strassburg CP, Sauerbruch T, Trautwein C, Wasmuth HE, Trebicka J. (2016): Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt. Liver Int., Mar, 36(3):386-94. doi: 10.1111/liv.12922. Epub 2015 Aug 17. PubMed PMID: 26212075., [4.470]
• Tetzner A , Gebolys K, Meinert C, Klein S, Uhlich A, Trebicka J, Villacañas Ó, Walther T (2016): G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A. Hypertension, ;68(1), 185-94, [6.350]
• Görtzen J , Hunka LM, Vonnahme M, Praktiknjo M, Kaifie A, Fimmers R, Jansen C, Heine A, Lehmann J, Goethert JR, Gattermann N, Goekkurt E, Platzbecker U, Brossart P, Strassburg CP, Brummendorf TH, Koschmieder S, Wolf D, Trebicka J. (2016): γ-Glutamyl Transferase Is an Independent Biomarker of Splanchnic Thrombosis in Patients With Myeloproliferative Neoplasm. Medicine (Baltimore), May;95(20), e3355. doi: 10.1097/MD.0000000000003355. PubMed PMID: 27196445; PubMed Central PMCID: PMC4902387,
• Jansen C , Bogs C, Krag A, Francque S, Trebicka J. (2016): Sequential shear-wave elastography of liver and spleen rules out clinically significant portal hypertension in compensated advanced chronic liver disease.. Gut, 66 (3), 558-559, [14.921]
• Trebicka J. (2016): Predisposing Factors in Acute-on-Chronic Liver Failure. Seminars Liver Disease, 36(2), 167-73, [5.667]
• Zimmer S. , Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E. (2016): Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Sciience Translational Medicine, 8 (333), 333ra50, [16.264]
• Beyer, M. , Abdullah Z., Chemnitz J.M., Maisel D., Sander J., Lehmann C., Thabet Y., Shinde P.V., Schmidleithner L., Köhne M., Trebicka J., Schierwagen R., Hofmann A., Popov A., Lang K.S., Oxenius A., Buch T., Kurts C., Heikenwalder M., Fätkenheuer G., Lang P.A., Hartmann P., Knolle P.A., Schultze J.L. (2016): Tumor necrosis factor impairs CD4+ T Cell-mediated immune control in chronic viral infection. Nature Immunology, , accepted, [19.381]
• Beyer M. , Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL (2016): Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.. Nat Immunol, May;17(5), 593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7. PubMed PMID: 26950238,
• Bissonnette J. , Garcia-Pagán JC, Albillos A, Turon F, Ferreira C, Tellez L, Nault JC, Carbonell N, Cervoni JP, Abdel Rehim M, Sibert A, Bouchard L, Perreault P, Trebicka J, Trottier-Tellier F, Rautou PE, Valla DC, Plessier A. (2016): Role of the transjugular intrahepatic portosystemic shunt in the management of severe complications of portal hypertension in idiopathic noncirrhotic portal hypertension. Hepatology, Jul;64(1), 224-31. doi: 10.1002/hep.28547. Epub 2016 May 13. PubMed PMID: 26990687, [11.711]
• Jansen, C. (2016): Algorithm to rule-out clinically significant portal hypertension combining Shear-wave elastography of liver and spleen: a prospective multi-center study. Gut, 65 (6), 1057-1058, [14.660]
• Laleman W. , Trebicka J., Verbeke L. (2016): Evolving insights in the pathophysiology of complications of cirrhosis: The Farnesoid-X receptor (FXR) to the rescue?. Hepatology, 64 (5), 1792-1794, [11.711]
• Clària J. , Stauber RE, Coenraad MJ, Moreau R, Jalan R, Pavesi M, Amorós À, Titos E, Alcaraz-Quiles J, Oettl K, Morales-Ruiz M, Angeli P, Domenicali M, Alessandria C, Gerbes A, Wendon J, Nevens F, Trebicka J, Laleman W, Saliba F, Welzel TM, Albillos A, Gustot T, Benten D, Durand F, Ginès P, Bernardi M, Arroyo V; (2016): CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (EF-CLIF). systemic inflammation in decompensated cirrhosis. Characterization and role in acute-on-chronic liver failure.. Hepatology, 64 (4), 1249-1264, [11.711]
• Merz W.M. , Rüland AM, Hippe V, Poetzsch B, Meyer C, Pollok JM, Gembruch U, Trebicka J. (2016): Pregnancy in Budd-Chiari Syndrome: Case Report and Proposed Risk Score. Medicine (Baltimore), 95(22), e3817, [2.133]
• Rudolph J. , Heine A, Quast T, Kolanus W, Trebicka J, Brossart P, Wolf D. (2016): The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK. Leukemia, 30, 2119-2123, [12.104]
• Trebicka, J. (2016): Assessment of beta-blocker response by expression fo beta-Arrestin2 and Rho/ROCK2 in antrum mucosa in cirrhotic patients. J Hepatol, , accepted, [11.370]
• Borhofen S.M. , Gerner C, Lehmann J, Fimmers R, Görtzen J, Hey B, Geiser F, Strassburg CP, Trebicka J. (2016): The Royal Free Hospital-Nutritional Prioritizing Tool Is an Independent Predictor of Deterioration of Liver Function and Survival in Cirrhosis. Digestive Diseases and Sciences, 61(6), 735-743, [2.516]
• Thiele M. , Detlefsen S, Sevelsted Møller L, Madsen BS, Fuglsang Hansen J, Fialla AD, Trebicka J, Krag A. (2016): Transient and 2-Dimensional Shear-Wave Elastography Provide Comparable Assessment of Alcoholic Liver Fibrosis and Cirrhosis. Gastroenterology, 150 (1), 123-33, [18.187]
• Trebicka J. , Schierwagen R. (2016): Hepatic mitochondrial dysfunction in nonalcoholic steatohepatitis: Read-out or reason?. Hepatology, 63(5), 1729-32, [11.711]
• Ariza X. , Graupera I, Coll M, Solà E, Barreto R, García E, Moreira R, Elia C, Morales-Ruiz M, Llopis M, Huelin P, Solé C, Fabrellas N, Weiss E, Nevens F, Gerbes A, Trebicka J, Saliba F, Fondevila C, Hernández-Gea V, Fernández J, Bernardi M, Arroyo V, Jiménez W, Deulofeu C, Pavesi M, Angeli P, Jalan R, Moreau R, Sancho-Bru P, Ginès P; CANONIC Investigators, EASL CLIF Consortium (2016): Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis. J Hepatol, Jul;65(1), 57-65. doi: 10.1016/j.jhep.2016.03.002. Epub 2016 Mar 14. PubMed PMID: 26988732, [10.590]
• Schierwagen, R. , Maybüchen, L., Zimmer, S., Hittatiya, K., Bäck, C., Klein, S., Uschner, F. E., Reul, W., Boor, P., Nickenig, G., Strassburg, C. P., Trautwein, C., Plat, J., Lütjohann, D., Sauerbruch, J. (2015): Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Sci Rep, Aug 11;5, 12931, [5.580]
• Verbeke, L. , Farre, R., Verbinnen, B., Covens, K., Vanuytsel, T., Verhaegen, J., Komuta, M., Roskams, T., Chatterjee, S., Annaert, P., Vander Elst, I., Windmolders, P., Trebicka, J., Nevens, F., Laleman, (2015): The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.. American Journal of Pathology, 185(2), 409-419, [4.206]
• Trebicka, J. , Wix, C., von Heydebrand, M., Hittatiya, K., Reiberger, T., Klein, S., Schierwagen, R., Kristiansen, G., Peck-Radosavljevic, M., Fischer, H. P., Møller , S., Bendtsen, F., Krag, A., Sauerbruch, T. (2015): Expression of vasoactive proteins in gastric antral mucosa reflects vascular dysfunction in patients with cirrhosis and portal hypertension.. Liver International, 35(4), 1993-1402, [4.470]
• Scholten, D. , Trebicka, J., Liedtke, C., Weiskirchen, R. (2015): The carbon tetrachloride model in mice.. Laboratory Animals, 49(1), 4-11, [1.553]
• Sauerbruch, T. , Mengel, M., Dollinger, M., Zipprich, A., Panther, E., Wiest, R., Caca, K., Hoffmeister, A., Lutz, H., Schoo, R., Lorenzen, H., Trebicka, J., Appenrodth, B., Schepke, M., Fimmers, . (2015): Prevention of Rebleeding From Esophageal Varices in Patients With Cirrhosis Receiving Small-Diameter Stents Versus Hemodynamically Controlled Medical Therapy.. Gastroenterology, 60 (11), 3456-3465, [18.187]
• Ramadori, P , Weiskirchen, R., Trebicka, J., Streetz, K. (2015): Mouse models of metabolic liver injury.. Lab Animals, 49(S1), 47-58., [1.553]
• Plompen, E. P. , Valk, P. J., Chu, I., Darwish Murad, S., Plessier, A., Turon, F., Trebicka, J., Primignani, M., Garcia-Pagán, J. C., Valla, D. C., Janssen, H. L., Leebeek, F. W. (2015): Somatic calreticulin mutations in patients with Budd-Chiari syndrome and portal vein thrombosis. Haematologica, 100(6), e226-e228., [6.671]
• Anadol, E. P. , Schierwagen, R., Elfimova, N., Tack, K., Schwarze-Zander, C., Eischeid, H., Noetel, A., Boesecke, C., Jansen, C., Dold, L., Wasmuth, J. C., Strassburg, C. P., Spengler, U., Rockstroh, J. K., Odenthal, . (2015): Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients.. Hepatology, 61(1), 46-55, [11.050]
• Marcías-Rodríguez, R. U. , Duarte-Rojo, A., Cantú-Brito, C., Sauerbruch, T., Ruiz-Margáin, A., Trebicka, J., Green-Gómez, M., Díaz Ramírez, J. B., Sierra Beltrán, M., Uribe-Esquivel, M., Torre, A. (2015): Cerebral haemodynamics in cirrhotic patients with hepatic encephalopathy.. Liver Int, 35(2), 344-352, [4.470]
• Leeming, D. J. , Veidal, S. S., Karsdal, M. A., Nielsen, M. J., Trebicka, J., Busk, T., Bendtsen, F., Krag, A., Møller, S. (2015): Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis. Scand J Gastroenterol, 50(5), 584-592, [2.199]
• Kukuk, G. M. , Hittatiya, K., Sprinkart, A. M., Eggers, H., Gieseke, J., Block, W., Moeller, P., Willinek, W. A., Spengler, U., Trebicka, J., Fischer, H. P., Schild, H. H., Träber, F. (2015): Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis. Eur Radiol, , [Epub ahead of print], [3.640]
• Jansen, C. , Reiberger, T., Huang, J., Eischeid, H., Schierwagen, R., Mandorfer, M., Anadol, E., Schwabl, P., Schwarze-Zander, C., Warmecke-Eberz, U., Strassburg, C. P., Rockstroh, J. K., Peck-Radosavljevic, M., Odenthal, M., Trebicka, . (2015): Circulating miRNA-122 levels are associated with hepatic necroinflammation and portal hypertension in HIV/HCV coinfection.. PLoS One, 10(2), e0116768-, [3.057]
• Jalan, R. , Pavesi, M., Saliba, F., Amorós, A., Fernandez, J., Holland-Fischer, P., Sawhney, R., Mookerjee, R., Caraceni, P., Moreau, R., Caraceni, P., Moreau, R., Ginès, P., Durand, F., Angeli, W., Trebicka, J., Samuel, D., Zeuzem, S., Gustot, T., Gerbes, A. L., Wendon, J., Bernardi, M., Arroyo, V. (2015): The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure.. J Hepatol, 62(4), 831-840, [10.590]
• Gustot, T. , Fernandez, J., Garcia, E., Morando, F., Caraceni, P., Alessandria, C., Laleman, W., Trebicka, J., Elkrief, L., Hopf, C., Solis-Munoz, P., Saliba, F., Zeuzem, S., Albilos, A., Benten, M. T., Concepción, M., Córdoba, J., McCormick, A., Stauber, R., Vogel, W., de Gottardi, A., Welzel, T. M., Domenicali, M., Risso, A., Wndon, J., Deulofeu, C., Angeli,P., Durand, F., Pavesi, M., Gerbes, A., Jalan, R., Moreau, R., Ginés, P.,Bernardi, M., Arroyo, V. (2015): Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis.. Hepatology, 62(1), 243-252, [11.050]
• Berres, M. L. , Asmacher, S. S., Lehmann, J., Jansen, C., Görtzen, J., Klein, S., Meyer, C., Strunk, H. M., Fimmers, R., Tacke, F., Strassburg, C. P., Trautwein, C., Sauerbruch, T., Wasmuth, H. E., Trebicka (2015): CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt.. J Hepatol, 62(2), 332-339, [11.370]
• Schierwagen R. , Maybüchen L, Zimmer S, Hittatiya K, Bäck C, Klein S, Uschner FE, Reul W, Boor P, Nickenig G, Strassburg CP, Trautwein C, Plat J, Lütjohann D, Sauerbruch T, Tacke F, Trebicka J. (2015): Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Scientific Reports, 5, 3456-64, [5.228]
• Berres, M. L. , Lehmann, J., Jansen, C., Görtzen, J., Meyer, C., Thomas, D., Zimmermann, H. W., Kroy, D., Schuhmacher, F., Strassburg, C. P., Sauerbruch, T., Trautwein, C., Wasmuth, H. E., Trebicka, J. (2015): Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt.. Liver Int, Mar;36(3), 386-94, [4.850]
• Nielsen M.J. , Lehmann J, Leeming DJ, Schierwagen R, Klein S, Jansen C, Strassburg CP, Bendtsen F, Møller S, Sauerbruch T, Karsdal MA, Krag A, Trebicka J. (2015): Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS. Dig Dis Sci., Nov, 60(11):3456-64. doi: 10.1007/s10620-015-3783-9. Epub 2015 Jul 3. PubMed PMID: 26138655, [2.516]
• Nielsen, M. J. , Lehmann, J., Leeming, D. J., Schierwagen, R., Klein, S., Jansen, C., Strassburg, C. P., Bendtsen, F., Møller, S., Sauerbruch, T., Karsdal, M. A., Krag, A., Trebicka, J. (2015): Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS.. Dig Dis Sci, Nov;60(11), 3456-64. doi: 10.1007/s10620-015-3783-9. Epub 2015 Jul 3., [2.610]
• de Franchis R. , Baveno VI Faculty (2015): Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol, Sep;63(3), 743-52. doi: 10.1016/j.jhep.2015.05.022. Epub 2015 Jun 3. PubMed PMID: 26047908,
• Klein, S. , Rick J., Lehmann J., Schierwagen R., Schierwagen I.G., Verbeke L., Hittatiya K., Uschner F.E., Manekeller S., Strassburg C.P., Wagner K.U., Sayeski P.P., Wolf D., Laleman W., Sauerbruch T., Trebicka J. (2015): Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.. Gut, [14.921]
• Klein, S. (2015): Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis.. PLoS One, 10 (9), e0138732, [3.057]
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