Q3 Prof. Dr. Weiskirchen
FACS-based cell isolation and clinical translation
The Q3 Core Unit provides the projects with reliably, standardized and efficiently isolated primary cells from liver and kidney from mice and rats. We have established FACS-based protocols for isolating hepatic stellate cells, sinusoidal endothelium as well as renal podocytes and parietal cells. We are currently extending our protocols to human cell types for translational projects. [...]
This core facility established innovative procedures that provide researchers of the SFB/TRR57 with healthy viable primary cells of murine and rat livers and kidneys in a very reliable, standardised and cost-effective centralised manner. Using conventional isolation procedures, we have set up a logistical and methodological platform that routinely provides primary hepatic stellate cells and hepatocytes to all projects in Aachen and Bonn upon request. Moreover, we have introduced novel FACS-based sorting protocols that allow isolation of highly purified hepatic stellate cells from murine livers using their autofluorescence in the UV channel and negativity for hematopoietic surface markers. Other protocols, both FACS- and MACS-based, were established for the isolation of different kidney cell types (podocytes, parietal cells, macrophages/dendritic cells), hepatic sinusoidal endothelial cells, oval cells as well as immune cells from liver and kidney from mice and rats.
We now expand our methodology to additionally provide the infrastructure for working with primary human liver cells to facilitate translational research within the SFB/TRR 57. Dr. Jeanette Bierwolf (Dept. of Visceral Surgery, UKB) will provide human hepatocytes from liver resections for individual projects upon request. Furthermore, we have started to establish techniques to isolate immune cell populations (macrophage subsets, lymphocytes) from human liver, based on the BMBF-funded biobanking program at the University Hospital Aachen.
We have furthermore published methodological papers on hepatic endothelial and stellate cell isolation techniques, thereby providing peer-reviewed references for the individual projects when referring to the methodology. During the last years, we have organized several internal methodological training courses for students and researchers within the SFB/TRR57 and hosted several national and international external scientists that were trained in these novel isolation techniques.
Publications
- Acharya P , Chouhan K., Weiskirchen S., Weiskirchen R. (2021): Cellular Mechanisms of Liver Fibrosis. frontiers in Pharmacology, 12, [5.330]
- Drescher H. K. , Schippers A., Rosenhain S., Gremse F., Bongiovanni L., de Bruin A., Eswaran S., Gallage S. U., Pfister D., Szydlowska M., Heikenwalder M., Weiskirchen S., Wagner N., Trautwein C., Weiskirchen R., Kroy D. C. (2020): L-Selectin/CD62L is a Key Driver of non-alcoholic Steatohepatitis in Mouse and Men. Cells, 9(5), 1106, [5.656]
- Azzam M. , El Safy S., Abdelgelil S. A., Weiskirchen R., Asimakopoulou A., de Lorenzi F., Lammers T., Mansour S., Tammam S. (2020): Targeting activated hepatic stellate cells using collagen-binding chitosan nanoparticles for siRNA delivery to fibrotic livers. Pharmaceutics, 12(6), 590, [4.773]
- Borkham-Kamphorst E. , Haas U., Van de Leur E., Trevanich A., Weiskirchen R. (2020): Chronic carbon tetra chloride applications induced hepatocyte apoptosis in Lipocaline 2 null mice through endoplasmic reticulum stress and unfolded protein response. International Journal of Molecular Sciences, 21(15), 5230, [4.183]
- Kim P. , Zhang C. C., Thoröe-Boveleth S., Weiskirchen S., Gaisa N. T., Buhl E. M., Stremmel W., Merle U., Weiskirchen R. (2020): Accurate Measurement of Copper Overload in an Experimental Model of Wilson Disease by Laser Ablation Inductively Coupled Plamsa Mass Spectrometry. Biomedicines, 8(9), 356, [3.600]
- Drescher H. K. , Bartsch L. M., Weiskirchen S., Weiskirchen R. (2020): Intrahepatic TH17/Treg cells in homeostasis and disease - it's all about balance. Front Pharmacol, 11, 588436, [3.845]
- Hermert D. , Martin I. V., Reiss L. K., Liu X., Breitkopf D. M., Reimer K. C., Alidousty C., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2020): The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis. Kidney International, 97(4), 741-752, [8.306]
- Weiskirchen S. , Weiper K., Tolba R. H., Weiskirchen R. (2020): All you can feed: Some comments on Production of mouse diets used in Biomedical Research with special emphasis on non-alcoholic fatty liver disease research. Nutrients, 12(1), 163,
- Yagmur E. , Otto S., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Decreased CTRP3 plasma concentrations are associated wtih sepsis and predict mortality in critically ill patients. Diagnostics, 9, 63, [2.489]
- Yagmur E. , Buergerhausen D., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Elevated CTRP1 plasma concentration is associated with sepsis and pre-existing type 2 diabetes mellitus in critically ill patients. J Clin Med, 8, 661, [5.583]
- Yagmur E. , Bast E., Mühlfeld A. S., Koch A., Weiskirchen R., Tacke F., Neulen J. (2019): High prevalence of sticky platelet syndrome in patients with infertility and pregnancy loss. J Clin Med, 8, 1328, [5.583]
- Weiskirchen S. , Kim P., Weiskirchen R. (2019): Laser ablation inductively coupled plasma spectrometry: metal imaging in experimental and clinical Wilson Disease. Inorganics, 7, 54, [1.900]
- Weiskirchen S. , Kim P., Weiskirchen R. (2019): Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma spectrometry. Annals Transl Med, 7(2), 72, [3.689]
- Weiskirchen R. , Weiskirchen S., Tacke F. (2019): Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications. Mol Aspects Med, 65, 2-15, [10.238]
- Weiskirchen R. , Weiskirchen S., Kim P., Winkler R. (2019): Software solutions for evaluation and visualization of laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI) data: a short overview. J Cheminform, 11, 16, [4.154]
- Weiskirchen R. , Tacke F. (2019): Pathophysiologie: Immunologie.“ Nichtalkoholische Fettleber. (Eds. Andreas Geier, Ali Canbay & Frank Lammert). Springer Verlag, im Druck, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic Fibrogenesis. Reference Module in Biomedical Sciences, , 1-7, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic fibrogenesis. Encyclopedia of Gastroenterology, 2nd Edition, Elsevier, New York, [0.200]
- Weiskirchen R. , Tacke F. (2019): Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease. Cells, 8, 16, [5.656]
- Weiskirchen R. , Stremmel W. (2019): Wilson disease: current knowledge, challenges and perspectives. Preface to the Focused Issue “Wilson’s disease: from genetics to management of disease (Eds. Ralf Weiskirchen & Wolfgang Stremmel). Annals Transl Med, 7(2), 55, [3.689]
- van Roeyen C. R. C. , Martin I. V., Drescher A., Schuett K. A., Hermert D., Raffetseder U., Otten S., Buhl E. M., Braun G., Kuppe C., Liehn E., Boor P., Weiskirchen R., Eriksson U., Gross O., Eitner F., Floege J., Ostendorf T. (2019): Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int, 95, 1103-1119, [8.000]
- Stremmel W. , Merle U., Weiskirchen R. (2019): Clinical features of Wilson disease. Annals Transl Med, 7(2), 61, [3.689]
- Stremmel W. , Staffer S. G., Weiskirchen R. (2019): Phosphatidylcholine passes by paracellular transport to the apical side of the polarized biliary tumor cell line Mz-ChA-1. Int J Mol Sci, 20, 4034, [4.183]
- Roderfeld M. , Padem S., Lichtenberger J., Quack T., Weiskirchen R., Longerich T., Schramm G., Churin Y., Irungbam K., Tschuschner A., Windhorst A., Grevelding C.G., Roeb E. (2019): Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes. Hepatology, 69, in press, [14.079]
- Pinheiro D. , Dias I., Silva K. R., Stumbo A. C., Thole A., Cortez E., de Carvalho L., Weiskirchen R., Carvalho S. (2019): Mechanisms underlying cell therapy in liver fibrosis: an overview. Cells, in press, [5.656]
- Mossanen J. C. , Kohlhepp M., Wehr A., Krenkel O., Liepelt A., Roeth A. A., Möckel D., Heymann F., Lammers T., Gassler N., Hermann J., Jankowski J., Neumann U. P., Luedde T., Trautwein C., Tacke F. (2019): CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence. Gastroenterology, 156(6), 1877-1889, [20.773]
- Meurer S.K. , Wimmer A.E., van de Leur E., Weiskirchen R. (2019): Endoglin trafficking/exosomal targeting in liver cells depends on N-glycosylation. Cells, 8, 997, [5.656]
- Mahli A. , Seitz T., Fresse K., Frank J., Weiskirchen R., Abdel-Tawab M., Behnam D., Hellerbrand C. (2019): Therapeutic application of micellar solubilized xanthohumol in a Western-type diet-induced mouse model of obesity, diabetes and non-alcoholic fatty liver disease. Cells, 8, 359, [5.656]
- Mahli A. , Seitz T., Beckröge T., Freese K., Thasler W.E., Benkert M., Dietrich P., Weiskirchen R., Bosserhoff A., Hellerbrand C. (2019): Bone morphogenetic protein-8B expression is induced in steatotic hepatocytes and promotes hepatic steatosis and inflammation in vitro. Cells, 8, 457, [5.656]
- Loosen S.H. , Koch A., Tacke F., Roderburg C., Luedde T. (2019): The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. Int J Mol Sci, 20(19), 4820, [4.183]
- Loosen S. H. , Lurje G., Wiltberger G., Vucur M., Koch A., Kather J. N., Paffenholz P., Tacke F., Ulmer F. T., Trautwein C. (2019): Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma. PLoS ONE, 14 (1), e0210944, [2.776]
- Loosen S. H. , Hoening P., Puethe N., Luedde M., Spehlmann M., Ulmer T. F., Cardenas D. V., Roy S., Tacke F., Trautwein C., Neumann U. P., Luedde T., Roderburg C. (2019): Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma. Sci Rep., 9(1), 1489, [4.011]
- Krenkel O. , Hundertmark J., Ritz T.P., Weiskirchen R., Tacke F. (2019): Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis. Cells, 8, 503, [5.656]
- Heymann F. , von Trotha K.-T., Preisinger C., Lynen-Jansen P., Roeth A. A., Geiger M., Geisler L. J., Frank A. K., Conze J., Luedde T., Trautwein C., Binnebösel M., Neumann U. P., Tacke F. (2019): Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation. JCI insight, [6.014]
- Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D.C., Drescher H.K. (2019): The inhibitory T cell receptors PD1 and 2B4 are differentially regulated on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis. Front Pharmacol, 10, 244, [3.845]
- Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D. C., Drescher H. K. (2019): The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis. frontiers in Pharmacology, [3.845]
- Gussen H. , Hohlstein P., Bartneck M., Warzecha K. T., Buendgens L., Luedde T., Trautwein C., Koch A., Tacke F. (2019): Neutrophils are a main source of circulating suPAR predicting outcome in critical illness. J Intensive Care, 7, 26, [3.510]
- Guillot A. , Tacke F. (2019): Liver Macrophages: Old Dogmas and New Insights. Hepatol Commun., 3 (6), 730-743, [0.800]
- Drescher H. K. , Weiskirchen R., Fülöp A., Hopf C., Gonzáles de San Roman E., Huesgen P.F., de Bruin A., Christ A., Tolba R., Trautwein C., Kroy D.C. (2019): The influence of different fat sources on steatohepatitis and fibrosis development in the Western diet mouse model of non-alcoholic steatohepatitis (NASH). Front Physiol, 10, 770, [3.394]
- Drescher H. K. , Weiskirchen S., Weiskirchen R. (2019): Current status in testing for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cells, 8, 845, [5.656]
- Borkham-Kamphorst E. , Van de Leur E., Haas U., Weiskirchen R. (2019): Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response. Cell Signal, 55, 90-99, [3.388]
- Bartneck M. , Schrammen P. L., Möckel D., Govaere O., Liepelt A., Krenkel O., Ergen C., McCain M. V., Eulberg D., Luedde T., Trautwein C., Kiessling F., Reeves H., Lammers T., Tacke F. (2019): The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers. Cell Mol Gastroenterol Hepatol, 7(2), 371-390, [6.850]
- Asimakopoulou A. , Vucur M., Luedde T., Weiss T.S., Schneiders S., Kalampoka S., Weiskirchen R. (2019): Perilipin 5 and Lipocalin 2 expression in hepatocellular carcinoma. Cancers, 11(3), 385, [6.162]
- Yagmur E. , Buendgens L., Herbers U., Beeretz A., Weiskirchen R., Koek G. H., Trautwein C., Tacke F., Koch A. (2018): High mobility group box 1 as a biomarker in critically ill patients. J Clin Lab Anal, 32(8), e22584, [1.728]
- Weiskirchen S. , Weiskirchen R. (2018): A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS. Atlas of Science, December, [0.200]
- Weiskirchen R. , Tacke F. (2018): The role of radiologic modalities in diagnosing non-alcoholic steatohepatitis (NASH) and fibrosis. Curr Hepat Rep, 17, 324-335, [0.200]
- Warzecha K. T. , Bartneck M., Möckel D., Appold L., Ergen C., Al Rawashdeh W., Gremse F., Niemietz P. M., Jahnen‐Dechent W., Trautwein C., Kiessling F., Lammers T., Tacke F. (2018): Targeting and Modulation of Liver Myeloid Immune Cells by Hard-Shell Microbubbles. Adv Biosyst, 2(5), 1-24, [2.855]
- Vucur M. , Roderburg C., Kaiser L., Schneider A. T., Roy S., Loosen S. H., Luedde M., Trautwein C., Koch A., Tacke F., Luedde T. (2018): Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Dis Markers, , 1983421, [2.761]
- Ullmann P. , Rodriguez F., Schmitz M., Meurer S. K., Qureshi-Baig K., Felten P., Ginolhac A., Antunes L., Frasquilho S., Zügel N., Weiskirchen R., Haan S., Letellier E. (2018): The microRNA-371~373 cluster represses colon cancer initiation and metastatc colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Res, 78, 3793-3808, [8.378]
- Tacke F. , Weiskirchen R. (2018): An update on the recent advances in antifibrotic therapies. Exp Rev Gastroenterol Hepatol, 12(11), 1143-1152, [2.991]
- Sonntag R. , Giebeler N., Nevzorova Y. A., Bangen J. M., Fahrenkamp D., Lambertz D., Haas U., Hu W., Gassler N., Cubero F. J., Müller-Newen G., Abdallah A. T., Weiskirchen R., Ticconi F., Costa I. G., Barbacid M., Trautwein C., Liedtke C. (2018): Cyclin E1 and Cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. Proc Natl Acad Sci USA, 115, 9282-9287, [9.580]
- Schröder S. K. , Asimakopoulou A., Weiskirchen R. (2018): Lipocalin 2 as a potential diagnostic and/or prognostic biomarker in prostate, lung and liver cancer. Clinics of Oncology, 1(3), 1-16, [0.200]
- Puengel T. , Tacke F. (2018): Repair macrophages in acute liver failure. Gut, 67(2), 202-203, [17.160]
- Pombeiro I. , Loosen S. H, Roy S., Schueller F., Niewenhuisen L., Luedde M., Vucur M., Tacke F., Binnebösel M., Schoening W., Trautwein C., Luedde T., Neumann U. P., Roderburg C. (2018): Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer. J Clin Med, 7(7), 175, [5.583]
- Moellmann J. , Klinkhammer B. M., Onstein J., Stöhr R., Jankowski V., Jankowski J., Lebherz C., Tacke F., Marx N., Boor P., Lehrke M. (2018): Glucagon-like peptide-1 and its cleavage products are renoprotective in murine diabetic nephropathy. Diabetes, 67(11), 2410-2419, [7.199]
- Luedde M. , Spehlmann M. E., Hippe H.-J., Loosen S. H., Roy S., Cardenas D. V., Vucur M., Frey N., Koch A., Luedde T., Trautwein C., Tacke F., Roderburg C. (2018): Serum levels of kisspeptin are elevated in critically ill patients. PLoS ONE, 13(10), e0206064, [2.776]
- Loosen S. H. , Tacke F., Binnebosel M., Leyh C., Vucur M., Heitkamp F., Schoening W., Ulmer T. F., Alizai P. H., Trautwein C., Koch A., Longerich T., Roderburg C., Neumann U. P., Luedde T. (2018): Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases. Oncotarget, 9(43), 27027-27038, [5.168]
- Loosen S. H. , Schulze-Hagen M., Leyh C., Benz F., Vucur M., Kuhl C., Trautwein C., Tacke F., Bruners P., Roderburg C., Luedde T. (2018): IL-6 and IL-8 Serum Levels Predict Tumor Response and Overall Survival after TACE for Primary and Secondary Hepatic Malignancies. Int J Mol Sci, 19(6), 1766, [4.183]
- Koch A. , Yagmur E., Linka J., Schumacher F., Bruensing J., Buendgens L., Herbers U., Koek G. H., Weiskirchen R., Trautwein C., Tacke F. (2018): High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients. Dis Markers, 8583121, [2.761]
- Koch A. , Yagmur E., Hoss A., Buendgens L., Herbers U., Weiskirchen R., Koek G. H., Trautwein C., Tacke F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J Clin Lab Anal, , e22614, [1.728]
- Koch A. , Weiskirchen R., Krusch A., Bruensing J., Buendgens L., Herbers U., Yagmur E., Koek G. H., Trautwein C., Tacke F. (2018): Visfatin serum levels predict mortality in critically ill patients. Dis Markers, 7315356, [2.761]
- Kim P. , Weiskirchen S., Uerlings R., Kueppers A., Stellmacher F., Viveiros A., Zoller H., Weiskirchen R. (2018): Quantification of liver iron overload disease with laser ablation inductively coupled plasma mass spectrometry. BMC Med Imaging, 18, 51, [1.622]
- Gauthier A. , Fisch A., Seuwen K., Baumgarten B., Ruffner H., Aebi A., Rausch M., Bartneck M., Weiskirchen R., Tacke F., Storm G., Lammers T., Ludwig M.-G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials, 178, 481-495, [10.273]
- Borkham-Kamphorst E. , Steffen B. T., van de Leur E., Haas U., Weiskirchen R. (2018): Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis. Cell Signal, 51, 72-85, [3.388]
- Meurer, S. K. , Weiskirchen, R. (2018): Activation by Inhibition. Atlas of Science,
- Uerlings, R. , Moreno D., Murillo, O., Gazquez, C., Hernandez-Alcoceba, R., Gonzalez-Aseguinolaza, G., Weiskirchen, R. (2018): Brain copper storage after long-term correction of Wilson's disease in a murine model of gene therapy. Neurol. Genet., 4, e243,
- Koch, A. , Yagmur, E., Hoss, A., Buendgens, L., Herbers, U., Weiskirchen, R., Koek, G. H., Trautwein, C., Tacke, F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J. Clin. Lab. Anal., in press., doi: 10.1002/jcla.22614,
- Yagmur, E. , Koch, A., Weiskirchen, R. Trautwein, C., Tacke, F. (2018): Clinical relevance of elevated high-mobility group box 1 (HMGB1) in critically ill patients. J. Clin. Lab. Anal., 33, e22614,
- Gauthier, A. , Fisch, A., Seuwen, K., Baumgarten, B., Ruffner, H., Aebi, A., Rausch, M., Bartneck, M., Weiskirchen, R., Tacke, F., Storm, G., Lammers, T., Ludwig, M. G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolutive phenotype in human primary macrophages to support healing of chronic wounds. Biomaterials, 04.006, in press,
- Koch, A. , Yagmur, E., Linka, J., Schumacher, F., Bruensing, J., Buendgens, L., Herbers, U., Koek, G. H., Weiskirchen, R., Trautwein, C., Tacke, F. (2018): High circulating caspase-cleaved keratin 18 fragments (M30) indicate short-term mortality in critically ill patients. Dis. Markers, 2018, 8583121,
- Schröder, S. K. , Asimakopoulou, A., Weiskirchen, R. (2018): Lipocalin 2 as a potential diagnostic and/or prognostic biomarker in prostate, lung and liver cancer. Clinics of Oncol., in press,
- Borkham-Kamphorst, E. , Van de Leur, E., Buhl, E. M., Meurer, S. K., Weiskirchen, R. (2018): N-glycosylation of Lipocalin 2 is not required for secretion or exosome targeting.. Front. Pharmacol., 9:426,
- Weiskirchen, R. , Weiskirchen, S., Tacke, F. (2018): Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications. Mol Aspects Med., , in press. doi: 10.1016/j.mam.2018.06.003,
- Weiskirchen, R. , Weiskirchen, S., Tacke, F. (2018): Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts. F1000, Res. 7, 921,
- Jenkitkasemwong, S. , Akinyode, N., Paulus, E., Weiskirchen, R., Hojyo, S., Fukada, T., Giraldo, G., Schrier, J., Garcia, A., Janus, C., Giasson, B., Knutson, M. D. (2018): SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc. Natl. Acad. Sci. U S A, 115, E1769-E1778,
- Lenk, L. , Pein, M., Will, O., Gomez, B., Viol, F., Hauser, C., Egberts, J.-H., Gundlach, P., Tiwari, S., Weiskirchen, R., Rose-John, S., Röcken, C., Mikulits, W., Wenzeli, P., Schneider, G., Saur, D., Schäfer, H., Sebens, S. (2018): The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. OncoImmunology, 7, e1368603,
- Ullmann, P. , Rodriguez, F., Schmitz, M., Meurer, S. K., Qureshi-Baig, K., Felten, P., Ginolhac, A., Antunes, L., Frasquilho, S., Zügel, N. Weiskirchen, R., Haan, S., Letellier, E. (2018): The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Res., in press,
- Krenkel, O. , Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., Weiskirchen, R., Longerich, T., Costa, I. G., Anstee, Q. M., Trautwein, C., Tacke, F. (2018): Therapeutic inhibition of inflammatory monocytes reduces steatohepatitis and liver fibrosis. Hepatology, 67, 1270-1283,
- Weiskirchen, S. , Weiskirchen, R. (2018): Ultrapure cells for liver research. Atlas of Science, May 30, 2018,
- Meurer, S. K. , Weiskirchen, R. (2018): Usage of Mitogen-Activated Protein Kinase small molecule inhibitors: more than just inhibition!. Front. Pharmacol., 9:98,
- Moreno, D. , Murillo, O., Gazquez, C., Hernandez-Alcoceba, R., Uerlings, R., Gonzalez-Aseguinolaza, G., Weiskirchen, R. (2018): Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry. J. Hepatol., 68, 199-201,
- Alsamman, M. , Sterzer, V., Meurer, S. K., Sahin, H., Schaeper, U., Kuscuoglu, D., Strnad, P., Weiskirchen, R., Trautwein, C., Scholten, D. (2018): Endoglin in human liver disease and murine models of liver fibrosis – a protective factor against liver fibrosis. Liver International, 38, 858-867, [4.470]
- Vucur, M. , Roderburg, C., Kaiser, L., Schneider, A.T., Roy, S., Loosen, S., Luedde, M., Trautwein, C., Koch, A., Tacke, F., Luedde, T. (2017): Elevated serum levels of the mixed lineage kinase domain-like protein (MLKL) predict survival of patients during intensive care unit treatment. Hindawi, [2.348]
- Loosen, S.H. , Roderburg, C., Kauertz, K.L., Koch, A., Vucur, M., Schneider, A.T., Binnebösel, M., Ulmer, T.F., Lurje, G., Schoening, W., Tacke, F., Trautwein, C., Longerich, T., Dejong, C.H., Neumann, U.P., Luedde, T. (2017): CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma. Scientific Reports, 7, [5.228]
- Lambertz, J. , Berger, T., Mak, T.W., van Helden, J., Weiskirchen, R. (2017): Lipocalin-2 in Fructose-Induced Fatty Liver Disease. frontiers in Physiology, [4.031]
- Hao, F. , Cubero, F.J., Ramadori, P., Liao, L., Haas, U., Lambertz, D., Sonntag, R., Bangen, J.M., Gassler, N., Hoss, M., Streetz, K.L., Reissing, J., Zimmermann, H.W., Trautwein, C., Liedtke, C., Nevzorova, Y.A. (2017): Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice. Cell Death & Disease, 8 (10), [5.378]
- Bangen, J.M. , Hammerich, L., Sonntag, R., Baues, M., Haas, U., Lambertz, D., Longerich, T., Lammers, T., Tacke, F., Trautwein, C., Liedtke C. (2017): Targeting CCl4 -induced liver fibrosis by RNA interference-mediated inhibition of cyclin E1 in mice. Hepatology, 66 (4), 1242-1257, [13.246]
- Puengel, T. , Krenkel, O., Kohlhepp, M., Lefebvre, E., Luedde, T., Trautwein, C., Tacke, F. (2017): Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury. PLoS One, [3.057]
- Buendgens, L. , Yagmur, E., Bruensing, J., Herbers, U., Baeck, C., Trautwein, C., Koch, A., Tacke, F. (2017): Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis. Disease Markers, 18, [2.348]
- Weiskirchen, S. , Weiskirchen R. (2017): Resveratrol: Is It Really Good for Liver Health?. Hepatitis Monthly, 17 (8), [1.932]
- Weiskirchen S. , Tag C.G., Sauer-Lehnen S., Tacke F., Weiskirchen R. (2017): Isolation and culture of primary murine hepatic stellate cells. Methods in Molecular Biology, 1627, 165-191, [1.170]
- Asimakopoulou A. , Borkham-Kamphorst E., Van de Leur E., Weiskirchen R. (2017): Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis. Data in Brief, August;13, 644-649, [0.200]
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- Dietzel E. , Weiskirchen S., Floehr J., Horiguchi M., Todorovic V., Rifkin D.B., Jahnen-Dechent W., Weiskirchen R. (2017): Latent TGF-β binding protein-1 deficiency decreases female fertility. Biochemical and Biophysical Research Communications, 482(4), 1387-1392, [2.371]
- Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F (2017): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44, [2.053]
- Meurer S.K. , Weiskirchen R. (2017): Endoglin (ENG). Encyclopedia of Signaling Molecules, 2nd Edition 2017 ISBN: 978-1-4419-0460-7, [0.200]
- Mossanen, J. , Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., Luedde, T., Marx, G., Strassburg, C., Roskams, T., Trautwein, C., Tacke, F. (2017): CCR2+ monocytes aggravate the early phase of acetaminophen induced acute liver injury. Journal of Hepathology, 64(5), 1667–1682, [10.590]
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- Uerlings, R. , Weiskirchen, R. (2017): An At-A-Glance Visualizatioon of Regional Metal Accretion in Tissue Samples via Image Overlay in Laser Ablation Inductively Coupled Plasma Mass Spectrometry. Laser Ablation: Advances in Research an Applications, Nova Science Publishers, 3, ISBN: 978-1-53612-408-8, [0.200]
- Weiskirchen R. (2017): Fast progression of liver damage in lysosomal acid lipase deficiency. Current Medical Research and Opinion, [2.643]
- Weiskirchen R. , Tacke F. (2017): Interleukin-33 in the pathogenesis of liver fibrosis: alarming ILC2 and hepatic stellate cells. Cellular & Molecular Immunology, 14 (2), 143-145, [5.193]
- Weiskirchen, R. (2016): Intratumor heterogeneity, variability and plasticity: Questioning the current concepts in classification and treatment of hepatocellular carcinoma.. Hepatobiliary Surg Nutr, 5, 183-187, [3.050]
- Weiskirchen, R. (2016): Hepatoprotective and anti-fibrotic agents: It’s time to take the next step.. Frontiers in Pharmacology, 6, 303, [4.418]
- van Helden, J. , Weiskirchen, R. (2016): Diagnostischer Wert der quantitativen HBsAg Bestimmung bei der Hepatitis B Infektion (Diagnostic value of the quantitative HBsAg determination in hepatitis B infections).. Zeitschrift für Gastroenterologie, 54, 319-326, [1.357]
- Susnea, I. , Weiskirchen, R. (2016): Trace metal imaging in diagnostic of hepatic metal disease.. Mass Spectrometry Reviews, 35 (6), 666-686, [9.346]
- Uerlings, R , Matusch, A., Weiskirchen, R. (2016): Reconstruction of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) spatial distribution images in Microsoft Excel 2007.. Int J Mass Spectrom, 395, 27-35, [1.183]
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- Borkham-Kamphorst, , Weiskirchen, R. (2016): The PDGF system and its antagonists in liver fibrosis.. Cytokine Growth Factor Rev, 28C, 53-61, [6.571]
- Borkham-Kamphorst, E. , Steffen, B. T., van de Leur, E., Haas, U., Tihaa, L., Friedman, S. L., Weiskirchen, R. (2016): CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.. Cell Signal, 28, 34-42, [4.191]
- Weiskirchen, R. , Tacke, F. (2016): Neue Therapieoptionen für die Leberfibrose: Aus der Forschung in die Klinik. New treatment options for liver fibrosis: From-bench-to-bedside.. Der Gastroenterologe, 11, 40-46, [0.200]
- Asimakopoulou, A. , Borkham-Kamphorst, E., Tacke, F., Weiskirchen, R. (2016): Lipocalin-2 (NGAL/LCN2), a "HELP-ME" signal in organ inflammation.. Hepatology, 63, 669-671, [11.711]
- Weiskirchen, R. , Tacke, F. (2016): Liver fibrosis: from pathogenesis to novel therapies.. Digestive Diseases and Sciences, 34, 410-422, [2.516]
- Meurer S.K. , Neß M, Weiskirchen S, Kim P, Tag CG, Kauffmann M, Huber M, Weiskirchen R. (2016): Isolation of mature (peritoneum-derived) mast cells and immature (bone marrow-derived) mast cell precursors from mice. PLoS One, 11(6), e0158104, [3.057]
- Merle U. , Weiskirchen R. (2016): Wilson's disease: An inherited, silent, copper intoxication disease. Eur Med J. Neurol., 4:, 74-83, [1.920]
- Weiskirchen S. , Weiskirchen R. (2016): Resveratrol: How much wine do you have to drink to stay healthy?. Advances in Nutrition, 7, 706-718, [5.201]
- Weiskirchen R. , Tacke F. (2016): Leberfibrose: von der Pathologie zu den Therapiemöglichkeiten. Falk Gastro-Kolleg., , 1-11, [0.200]
- Weiskirchen R. , Tacke F. (2016): Liver fibrosis – which mechanisms matter?. Clinical Liver Disease, 8 (4), 94-99, [0.360]
- Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F. (2016): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44,
- Schon H.T. , Bartneck M., Borkham-Kamphorst E., Nattermann J., Lammers T., Tacke F., Weiskirchen R. (2016): Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis. Frontiers in Pharmacology, 7, 33, [4.418]
- Koppe C. , Verheuged P., Gautheron J., Reisinger F., Kreggenwinkel K., Roderburg C., Quagliata L., Terracciano L., Gassler N., Tolba R., Boege Y., Weber A., Karin M., Luedde M., Neumann U. P., Weiskirchen R., Tacke F., Vucur M., Trautwein C., Lüscher B., Preisinger C., Heikenwälder M., Lüdde T. (2016): IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylation the cell death mediator RIPK1. Hepatology, 64 (4), 1217-1231, [11.711]
- Borkham-Kamphorst E. , Steffen B. T., Van de Leur E., Tihaa L., Haas U., Weiskirchen R. (2016): Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response. BBA Mol Cell Res., 1863, 2604-2612, [5.128]
- Kanta J. , Mrkvicová A., Weiskirchen R. (2016): Editorial: Liver myofibroblasts. Frontiers in Physiology, 7, 343, [4.031]
- Schon H.-T. , Weiskirchen R. (2016): Exercise-induced release of pharmacologically active substances and their relevance for therapy of hepatic injury. Frontiers in Pharmacology, 7, 283, [4.418]
- Wallace, M. C., , Hamesch, K., Lunova, M., Kim, Y., Weiskirchen, R., Strnad, P., Friedman, S. L. (2015): Standard Operating Procedures in experimental liver research: Thioacetamide model in mice. Laboratory Animals, 49(1), 59-69, [1.120]
- Tolba, R. H. , Riediger, B. M., Weiskirchen, R. (2015): Standard Operating Procedures in experimental liver research: time to achieve uniformity. Lab Animals, 49(S1), 21-29, [1.553]
- van Helden, J. , Weiskirchen, R. (2015): Experience with the first fully automated chemiluminescence immunoassay for the quantification of 1α, 25-Dihydroxy-Vitamin D. Clin Chem Lab Med, 53, 761-770, [3.017]
- Tolba, R. H. , Kraus, T., Liedtke, C., Schwarz, M., Weiskirchen, R. (2015): Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice.. Laboratory Animals, 49(1), 59-69, [1.553]
- Hamesch, K. , Borkham-Kamphorst, E., Strnad, P., Weiskirchen, R. (2015): Lipopolysaccharide-induced inflammatory liver injury in mice.. Lab Anim, 49(S1), 37-46, [1.120]
- Borkham-Kamphorst, E. , Meurer, S. K., Van de Leur, E., Haas, U., Tihaa, L., Weiskirchen, R. (2015): PDGF-D signalling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β.. Cell Signal, 27, 1305-1314, [4.320]
- Borkham-Kamphorst, E. , Alexi, P., Tihaa, L., Haas, U., Weiskirchen, R. (2015): Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.. Biochem Biophys Res, Commun 457, 307-313, [2.300]
- Boaru, S. G. , Borkham-Kamphorst, E., Van de Leur, E., Lehnen, E., Liedtke, C., Weiskirchen, R. (2015): NLRP3 inflammasome expression is driven by NF-kB in cultured hepatocytes.. Biochem Biophys Res Commun, 458, 700-706, [2.300]
- Boaru, S. G. , Merle, U., Uerlings, R., Zimmermann, A., Willheim, C., Ferenci, P., Stremmel, W., Weiskirchen, R. (2015): Laser ablation inductively coupled plasma mass spectrometry imaging of metals in experimental and clinical Wilson's disease.. J Cell Mol Med, 19, 806-814, [4.010]
- Asimakopoulou, A. (2015): Lipocalin 2 in the pathogenesis of fatty liver disease and non-alcoholic steatohepatitis.. Clin. Lipidol, 10, 47-67, [0.870]
- Uerlings, R. , Weiskirchen, R. (2015): Laser ablation inductively coupled plasma mass spectrometry in biomedicine and clinical diagnosis.. Cellular & Molecular Medicine, open access 1, 1:-1, [5.193]
- Weiskirchen, R. , Tacke, F. (2015): Small heterodimer partner (SHP) links hepatitis C and liver fibrosis: a small protein on the big stage. Liver Int, 35, 2218-2221, [4.470]
- Tag, C. G , Sauer-Lehnen, S., Weiskirchen, S., Borkham-Kamphorst, E., Tolba, R. H., Tacke, F., Weiskirchen, R. (2015): Bile duct ligation in mice: Induction of inflammatory liver injury and fibrosis by obstructive cholestasis.. Journal of Visualized Experiments, 96, e52438, [1.240]
- Tag, C. G. , Weiskirchen, S. K., Hittatiya, K., Tacke, F., Tolba, R. H., Weiskirchen, R. (2015): Induction of experimental obstructive cholestasis in mice.. Laboratory Animals, 49(1), 70-80, [1.553]
- Heymann, F. , Hamesch, K., Weiskirchen, R., Tacke, F. (2015): The Concanavalin A model of acute hepatitis in mice.. Lab Anim, 49(S1), 12-20., [1.120]
- Berres, M. L. , Asmacher, S. S., Lehmann, J., Jansen, C., Görtzen, J., Klein, S., Meyer, C., Strunk, H. M., Fimmers, R., Tacke, F., Strassburg, C. P., Trautwein, C., Sauerbruch, T., Wasmuth, H. E., Trebicka (2015): CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt.. J Hepatol, 62(2), 332-339, [11.370]
- Bartneck, M. , Warzecha, K. T., Tag, C. G., Sauer-Lehnen, S., Heymann, F., Trautwein, C., Weiskirchen, R., Tacke, F. (2015): Isolation and time lapse microscopy of highly pure hepatic stellate cells.. Anal Cell Pathol (Amst), Article ID-417023, [0.850]
- Bartneck, M. , Topuz, F., Tag, C. G., Sauer-Lehnen, S., Warzecha, C. T., Trautwein, C., Weiskirchen, R., Tacke, F. (2015): Molecular response of liver sinusoidal endothelial cells on hydrogels. Mater Sci Eng C Mater Biol, Appl 51, 64-72, [3.420]
- Winkler, S. , Borkham-Kamphorst, E., Stock, P., Brückner, S., Weiskirchen, R., Christ, B. (2014): Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model.. Experimental Cell Research, 326 (2), 230-239, [3.930]
- van Helden , J. , Weiskirchen, R (2014): Hepatitis C diagnostics: clinical evaluation of the HCV-core antigen determination (Hepatitis C Diagnostik: Klinische Evaluierung der HCV-core Antigen Bestimmung). Zeitschrift für Gastroenterologie, 52(10), 1164-1170, [1.357]
- Schon, H. T , Weiskirchen, R. (2014): Immunmodulatory effects of transforming growth factor-β in the liver.. Hepatobiliary Surgery and Nutrition, 3, 386-406, [3.050]
- Meurer, S. K. , Alsamman, M., Scholten, D., Weiskirchen, R. (2014): Endoglin in liver fibrogenesis – Bridging basic science and clinical practice.. World J. Biol Chem, 5(2), 180-203,
- Martinez-Palacian, A. , Martinez-Palacian, A., Kanse, S. M., Weiskirchen, R. (2014): Factor VII activating protease (FSAP): A novel protective factor in liver fibrosis. Proteomics Clinical Applications, 8(5-6), 438-446, [2.959]
- Bultmann, C. A. , Weiskirchen, R. (2014): MAKERGAUL: An innovative MAK-based model and software for real-time PCR quantification.. Clin Biochem, 47(1-2), 117-122, [2.382]
- Borkham-Kamphorst E. , Schaffrath, C., van de Leur, E., Haas, U., Tihaa, L., Meurer, S. K., Nevzorova, Y. A., Liedtke, C., Weiskirchen, R. (2014): The anti-fibrotic effects of ccn1/cyr61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated tgf-beta signaling.. Biochim Biophys Acta, 1843(5), 902-914, [5.128]
- Boaru, S. G. , Merle, U., Uerlings, R., Zimmermann, A., Weiskirchen, S., Stremmel, W., Weiskirchen, R. (2014): Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometry.. BMC Neuroscience, , 15-98., [2.304]
- Asimakopoulou, A. , Borkham-Kamphorst, E., Henning, M., Yagmur, E., Gassler, N., Berger, T., Mak, T. W., Weiskirchen, R. (2014): Lipocalin 2 (LCN2) regulates OXPAT expression and intracellular lipid droplet formation in the liver.. BBA Mol Cell Biol Lipids, 1841 (10), 1513-1524, [4.779]
- Abnaof, K. , Mallela, N., Vinoid, N., Walenda, G., Meurer, S. K., Seré, K., Lin, Q., Smeets, B., Hoffmann, K., Wagner, W., Zenke, M., Weiskirchen, R., Fröhlich, H. (2014): TGF-beta stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Systems Biol, 8, 55, [2.208]
- Weiskirchen, R. , Tacke, F. (2014): Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology.. Hepatobiliary Surgery and Nutrition, 3 (6), 344-363, [3.050]
- Tacke, F. , Zimmermann, H. W. (2014): Macrophage heterogeneity in liver injury and fibrosis.. Journal of Hepatology, 60(5), 1090-1096, [10.590]
- Tacke, F. , Weiskirchen, R. (2014): Liver immunology: new perspectives. Hepatobiliary Surg Nutr, 3 (6), 330, [3.050]
- Tacke, F. , Roderburg, C., Benz, F., Cardenas, D. V., Luedde, M., Hippe, H. J., Frey, N., Vucur, M., Gautheron, J., Koch, A., Trautwein, C., Luedde, T. (2014): Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients.. Critocal Care Medicine, 42(5), 1096-1104, [7.422]
- Tacke, F. , Galm, O., Kanig, N., Yagmur, E., Brandt, S., Lindquist, J. A., Eberhardt, C. S., Raffetseder, U., Mertens, P. R. (2014): High prevalence of Y-box protein-1/p18 fragment in plasma of patients with malignancies of different origin.. BMC Cancer, 14, 33, [3.265]
- Hammerich, L. , Bangen, J. M., Govaere, O., Zimmermann, H. W., Gassler, N., Huss, S., Liedtke, C., Prinz, I., Lira, S. A., Luedde, T., Roskams, T., Trautwein, C., Heymann, F., Tacke, F. (2014): Chemokine receptor ccr6-dependent accumulation of gammadelta t cells in injured liver restricts hepatic inflammation and fibrosis.. Hepatology, 59(2), 630-642, [11.711]
- Koch, A. , Zimmermann, H. W., Gassler, N., Jochum, C., Weiskirchen, R., Bruensing, J., Buendgens, L., Dückers, H., Bruns, T., Gerken, G., Neumann, U. P., Adams, D. H., Trautwein, C., Canbay, A., Tacke, F. (2014): Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure.. Liver International, 34(9), 13301339, [4.470]
- Ehling, J. , Bartneck, M., Wie, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., Kiessling, F., Trautwein, C., Lammers, T., Tacke, F. (2014): CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.. Gut, 63(12), 1960-71, [14.921]
- Buendgens, L. , Bruensing, J., Matthes, M., Dückers, H., Luedde, T., Trautwein, C., Tacke, F., Koch, A. (2014): Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea. Journal of Critical Care, 29(4), 696, [2.445]
- Bartneck, M. , Peters, F. M., Warzecha, K. T., Bienert, M., van Bloois, L., Trautwein, C., Lammers, T., Tacke, F. (2014): Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages.. Nanomedicine, 10(6), 1209-1220, [5.671]
- Wehr, A. (2014): Pharmacological Inhibition of the Chemokine CXCL16 Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury.. PLoS One, 9 (11), [3.050]
- Baeck, C. , Wie, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., Tacke, F. (2014): Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice.. Hepatology, 59(3), 1060-1072, [11.711]
- Weiskirchen, R. , Meurer, S. K. (2013): BMP-7 counteracting TGF-beta1 activities in organ fibrosis. Frontiers in Bioscience (Landmark Ed), 18, 1407-1434, [2.484]
- Weiskirchen, R. , Weimer, J., Meurer, S. K., Kron, A., Seipel, B., Vater, I., Arnold, N., Siebert, R., Xu, L., Friedman, S. L., Bergmann, C. (2013): Genetic characteristics of the human hepatic stellate cell line LX-2.. PLoS One, 8 (10), [3.057]
- Sahin, H. , Borkham-Kamphorst, E., do, O. N., Berres, M. L., Kaldenbach, M., Schmitz, P., Weiskirchen, R., Liedtke, C., Streetz, K. L., Maedler, K., Trautwein, C., Wasmuth, H. E. (2013): Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.. Hepatology, 57 (2), 797-805, [11.711]
- M-M, P. , Weiskirchen, R., Gassler, N., Bosserhoff, A. K., Becker, J. S. (2013): Novel bioimaging techniques of metals by laser ablation inductively coupled plasma mass spectrometry for diagnosis of fibrotic and cirrhotic liver disorders.. PLoS One, 8 (3), [3.057]
- Meurer, S. K. , Alsamman, M., Sahin, H., Wasmuth, H. E., Kisseleva, T., Brenner, D. A., Trautwein, C., Weiskirchen, R., Scholten, D. (2013): Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line.. PLoS One, 8 (2), [3.057]
- Martin, I. V. , Borkham-Kamphorst E, Zok S, van Roeyen CRC, Eriksson U, Boor P, Hiththetiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T. (2013): Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis. The American Journal of Pathology, 182 (1), 107-117, [4.206]
- Labbus, K. , Henning, M., Borkham-Kamphorst, E., Geisler, C., Berger, T., Mak, T. W., Knuchel, R., Meyer, H. E., Weiskirchen, R., Henkel, C. (2013): Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions.. Journal of Proteomics, 78, 188-196, [3.867]
- Koch, A. , Weiskirchen, R., Kunze, J., Duckers, H., Bruensing, J., Buendgens, L., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.. Journal Critical Care, 28 (6), 947-953, [2.445]
- Huss, S. , Stellmacher, C., Goltz, D., Khlistunova, I., Adam, A. C., Trebicka, J., Kirfel, J., Buttner, R., Weiskirchen, R. (2013): Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice.. BMC Gastroenterology, 13, 8, [2.101]
- Cubero, F. J. , Singh, A., Borkham-Kamphorst, E., Nevzorova, Y. A., Al Masaoudi, M., Haas, U., Boekschoten, M. V., Gassler, N., Weiskirchen, R., Muller, M., Liedtke, C., Trautwein, C. (2013): Tnfr1 determines progression of chronic liver injury in the ikkgamma/nemo genetic model.. Cell Death & Differentiation, 20 (11), 1580-1592, [8.218]
- Borkham-Kamphorst, E. , Zimmermann, H. W., Gassler, N., Bissels, U., Bosio, A., Tacke, F., Weiskirchen, R., Kanse, S. M. (2013): Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.. Journal of Hepatology, 58 (1), 104-111, [10.590]
- Borkham-Kamphorst, E. , van de Leur, E., Zimmermann, H.W., Karlmark, K.R., Tihaa, L., Haas, U., Tacke, F., Berger, T., Mak, T.W., Weiskirchen, R., (2013): Protective effects of Lipocalin-2 (LCN2) in acute and chronic liver injury suggesting a novel function in liver homeostasis.. BBA Molecular Basis of Disease, 1832 (5), 660-73, [5.128]
- Wehr, A. , Baeck, C., Heymann, F., Niemietz, P. M., Hammerich, L., Martin, C., Zimmermann, H. W., Pack, O., Gassler, N., Hittatiya, K., Ludwig, A., Luedde, T., Trautwein, C., Tacke, F. (2013): Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis.. The Journal of Immunology, 190 (10), 5226-5236, [4.179]
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- Koch, A. , Horn, A., Duckers, H., Yagmur, E., Sanson, E., Bruensing, J., Buendgens, L., Voigt, S., Trautwein, C., Tacke, F. (2011): Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Critical Care, 15, R266, [4.950]
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