P06 Prof. Dr. Lüdde/Prof. Dr. Trautwein
Inflammatory and cell-death-related pathways in liver fibrosis: Cell-type specific approaches to novel therapies

The kinase RIPK3 regulates a novel form of programmed cell death called ‘necroptosis’ and other signaling pathways involved in cell death and inflammation. In the 2nd funding period, we could demonstrate that RIPK3 is overexpressed in human non-alcoholic steatohepatitis (NASH) and mediates NASH fibrosis in mice. In the 3rd funding period, P06 will therefore further elaborate the molecular targets of RIPK3 in NASH fibrosis and will put a major focus on translational aspects. Moreover, the project will investigate the important question if induction of programmed cell death in HSC via apoptosis (Caspase-dependent) or necroptosis (RIPK3-dependent) can prevent fibrosis. [...]

Publications

• Krause J. , Grabsch H. I., Kloor M., Jendrusch M., Echle A., Buelow R. D., Boor P., Luedde T., Brinker T. J., Trautwein C., Pearson A. T., Quirke P., Jenniskens J., Offermans K., van den Brandt P. A., Kather J. N. (2021): Deep learning detects genetic alterations in cancer histology generated by adversarial networks. Journal of Pathology, 254(1), 70-79, [5.979]
• Loosen S. H. , Schulze-Hagen M., Püngel T., Bündgens L., Wirtz T., Kather J. N., Vucur M., Paffenholz P., Demir M., Bruners P., Kuhl C., Trautwein C., Tacke F., Luedde T., Koch A., Roderburg C. (2020): Skeletal muscle composition predicts outcome in criticalliy ill patients. Critical Care Explorations, 2(8),
• Paffenholz P. (2020): Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: results from a nationwide online survey. Emerging Microbes & Infectons, 9(1), 1590-1599,
• Echle A. , Grabsch H. I., Quirke P., van den Brandt P. A., West N. P., Hutchins G. G. A., Heij L. R., Tan X., Richman S. D., Krause J., Alwers E., Jenniskens J., Offermans K., Gray R., Brenner H., Chang-Claude J., Trautwein C., Pearson A. T., Boor P., Luedde T., Gaisa N. T., Hoffmeister M., Kather J. N. (2020): Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology, 159, 1406-1416,
• Tacke F. , Spehlmann M.E., Vucur M., Benz F., Luedde M., Cardenas D.V., Roy S., Loosen S, Hippe H.J., Frey N., Trautwein C., Koch A., Roderburg C., Luedde T. (2019): miR-155 predicts lpongterm mortality in critically ill patiens younger than 65 years. Mediators Inflamm, [3.549]
• Roy S. , Hooiveld G. J., Seehawer M., Caruso S., Heinzmann F., Schneider A. T., Frank A. K., Vargas Cardenas D., Sonntag R., Luedde M., Trautwein C., Stein I., Pikarsky E., Loosen S., Tacke F., Ringelhan M., Avsaroglu S. K.,Goga A., Buendia M.-A., Vucur M., Heikenwalder M., Zucman-Rossi J., Zender L., Roderburg C., Luedde T. (2019): microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology, 155(6), 1951–1966, [20.773]
• Mossanen J. C. , Kohlhepp M., Wehr A., Krenkel O., Liepelt A., Roeth A. A., Möckel D., Heymann F., Lammers T., Gassler N., Hermann J., Jankowski J., Neumann U. P., Luedde T., Trautwein C., Tacke F. (2019): CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence. Gastroenterology, 156(6), 1877-1889, [20.773]
• Loosen S.H. , Schulze-Hagen M., Bruners P., Tacke F., Trautwein C., Kuhl C., Luedde T., Roderburg C. (2019): Sarcopenia Is a Negative Prognostic Factor in Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatic Malignancies. Cancers, 11(10), 1503, [6.162]
• Loosen S.H. , Koch A., Tacke F., Roderburg C., Luedde T. (2019): The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis. Int J Mol Sci, 20(19), 4820, [4.183]
• Loosen S. H. , Tacke F., Püthe N., Binneboesel M., Wiltberger G., Alizai P. H., Kather J. N., Paffenholz P., Ritz T., Koch A., Bergmann F., Trautwein C., Longerich T., Roderburg C., Neumann U. P., Luedde T. (2019): High baseline soluble urokinase plasminogen activator receptor (suPAR) serum levels indicate adverse outcome after resection of pancreatic adenocarcinoma. Carcinogenesis, 40(8), 947–955, [4.004]
• Loosen S. H. , Hoening P., Puethe N., Luedde M., Spehlmann M., Ulmer T. F., Cardenas D. V., Roy S., Tacke F., Trautwein C., Neumann U. P., Luedde T., Roderburg C. (2019): Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma. Sci Rep., 9(1), 1489, [4.011]
• Koppe C. , Reisinger F., Wehr K., Vucur M., Trautwein C., Tacke F., Heikenwalder M., Luedde T. (2019): An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration. Cancers, 11(7), 999, [6.162]
• Kather J. N. , Pearson A. T., Halama N., Jäger D., Krause J., Loosen S. H., Marx A., Boor P., Tacke F., Neumann U. P., Grabsch H. I., Yoshikawa T., Brenner H. B., Chang-Claude J., Hoffmeister M., Trautwein C., Luedde T. (2019): Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med, 25, 1054-1056, [30.641]
• Heymann F. , von Trotha K.-T., Preisinger C., Lynen-Jansen P., Roeth A. A., Geiger M., Geisler L. J., Frank A. K., Conze J., Luedde T., Trautwein C., Binnebösel M., Neumann U. P., Tacke F. (2019): Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation. JCI insight, [6.014]
• Gussen H. , Hohlstein P., Bartneck M., Warzecha K. T., Buendgens L., Luedde T., Trautwein C., Koch A., Tacke F. (2019): Neutrophils are a main source of circulating suPAR predicting outcome in critical illness. J Intensive Care, 7, 26, [3.510]
• Cubero F. J. , Peng J., Liao L., Su H., Zhao G., Zoubek M. E., Macías-Rodríguez R., Ruiz-Margain A., Reißing J., Zimmermann H. W., Gassler N., Luedde T., Liedtke C., Hatting M., Trautwein C. (2019): Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis. Journal of Hepatology, 69(6), 1326-1334, [10.590]
• Bartneck M. , Schrammen P. L., Möckel D., Govaere O., Liepelt A., Krenkel O., Ergen C., McCain M. V., Eulberg D., Luedde T., Trautwein C., Kiessling F., Reeves H., Lammers T., Tacke F. (2019): The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers. Cell Mol Gastroenterol Hepatol, 7(2), 371-390, [6.850]
• Asimakopoulou A. , Vucur M., Luedde T., Weiss T.S., Schneiders S., Kalampoka S., Weiskirchen R. (2019): Perilipin 5 and Lipocalin 2 expression in hepatocellular carcinoma. Cancers, 11(3), 385, [6.162]
• Vucur M. , Roderburg C., Kaiser L., Schneider A. T., Roy S., Loosen S. H., Luedde M., Trautwein C., Koch A., Tacke F., Luedde T. (2018): Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment. Dis Markers, , 1983421, [2.761]
• Uschner F. E. , Schueller F., Nikolova I., Klein S., Schierwagen R., Magdaleno F., Gröschl S., Loosen S., Ritz T., Roderburg C., Vucur M., Kristiansen G., Lammers T., Luedde T., Trebicka J. (2018): The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension. Oncotarget, 9(90), 36220-36237, [5.168]
• Pombeiro I. , Loosen S. H, Roy S., Schueller F., Niewenhuisen L., Luedde M., Vucur M., Tacke F., Binnebösel M., Schoening W., Trautwein C., Luedde T., Neumann U. P., Roderburg C. (2018): Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer. J Clin Med, 7(7), 175, [5.583]
• Luedde M. , Spehlmann M. E., Hippe H.-J., Loosen S. H., Roy S., Cardenas D. V., Vucur M., Frey N., Koch A., Luedde T., Trautwein C., Tacke F., Roderburg C. (2018): Serum levels of kisspeptin are elevated in critically ill patients. PLoS ONE, 13(10), e0206064, [2.776]
• Loosen S. H. , Tacke F., Binnebosel M., Leyh C., Vucur M., Heitkamp F., Schoening W., Ulmer T. F., Alizai P. H., Trautwein C., Koch A., Longerich T., Roderburg C., Neumann U. P., Luedde T. (2018): Serum levels of soluble urokinase plasminogen activator receptor (suPAR) predict outcome after resection of colorectal liver metastases. Oncotarget, 9(43), 27027-27038, [5.168]
• Loosen S. H. , Schulze-Hagen M., Leyh C., Benz F., Vucur M., Kuhl C., Trautwein C., Tacke F., Bruners P., Roderburg C., Luedde T. (2018): IL-6 and IL-8 Serum Levels Predict Tumor Response and Overall Survival after TACE for Primary and Secondary Hepatic Malignancies. Int J Mol Sci, 19(6), 1766, [4.183]
• Koch A. , Weiskirchen R., Krusch A., Bruensing J., Buendgens L., Herbers U., Yagmur E., Koek G. H., Trautwein C., Tacke F. (2018): Visfatin serum levels predict mortality in critically ill patients. Dis Markers, 7315356, [2.761]
• Cubero F. J. , Peng J., Liao L., Su H., Zhao G., Zoubek M. E., Macias-Rodriguez R., Ruiz-Margain A., Reissing J., Zimmermann H. W., Gassler N., Luedde T., Liedtke C., Hatting M., Trautwein C. (2018): Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis. J Hepatol, 69, 1326-1334, [18.946]
• Vucur, M. , Roderburg, C., Kaiser, L., Schneider, A.T., Roy, S., Loosen, S., Luedde, M., Trautwein, C., Koch, A., Tacke, F., Luedde, T. (2017): Elevated serum levels of the mixed lineage kinase domain-like protein (MLKL) predict survival of patients during intensive care unit treatment. Hindawi, [2.348]
• Loosen, S.H. , Roderburg, C., Kauertz, K.L., Koch, A., Vucur, M., Schneider, A.T., Binnebösel, M., Ulmer, T.F., Lurje, G., Schoening, W., Tacke, F., Trautwein, C., Longerich, T., Dejong, C.H., Neumann, U.P., Luedde, T. (2017): CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma. Scientific Reports, 7, [5.228]
• Schneider, A. , Gautheron, J., Feoktistova, M., Roderburg, C., Loosen, S. H., Roy, S., Benz, F., Schemmer, P., Büchler, M. W., Nachbur, U., Neumann, U. P., Tolba, R., Luedde, M., Zucman-Rossi, J., Panayotova-Dimitrova, D., Leverkus, M., Preisinger, C., Tacke, F., Trautwein, C., Longerich, T., Vucur, M., Luedde, T. (2017): RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell, 31 (1), 94–109, [23.214]
• Cubero, F. J. , Zoubek, M., Hu, W., Peng, J., Zhao, G., Nevzorova, Y. A., Al Masaoudi, M. , Bechmann, L., Boekschoten, M., Muller, M., Preisinger, C., Gassler, N., Canbay, A., Luedde, T., Davis, R., Liedtke,C., Trautwein, C. (2017): Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury. Gastroenterology, 150(4), 968–981, [18.187]
• Mossanen, J. , Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., Luedde, T., Marx, G., Strassburg, C., Roskams, T., Trautwein, C., Tacke, F. (2017): CCR2+ monocytes aggravate the early phase of acetaminophen induced acute liver injury. Journal of Hepathology, 64(5), 1667–1682, [10.590]
• Koppe C. , Verheuged P., Gautheron J., Reisinger F., Kreggenwinkel K., Roderburg C., Quagliata L., Terracciano L., Gassler N., Tolba R., Boege Y., Weber A., Karin M., Luedde M., Neumann U. P., Weiskirchen R., Tacke F., Vucur M., Trautwein C., Lüscher B., Preisinger C., Heikenwälder M., Lüdde T. (2016): IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylation the cell death mediator RIPK1. Hepatology, 64 (4), 1217-1231, [11.711]
• Cubero, F. J. , Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C. (2016): Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury.. Gastroenterology, Apr;150(4), 968-81, [18.187]
• Bartneck M. , Fech V., Ehling J., Govaere O., Theresa Warzecha K., Hittatiya K., Vucur M., Gautheron J., Luedde T., Trautwein C., Lammers T., Roskams T., Jahnen-Dechent W., Tacke F. (2016): Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease. Hepatology, 63(4), 1310-24,
• Verdier, J. (2015): Biliary Mucosal Barrier and Microbiome.. Viszeralmedizin, 31, 156-161,
• Roy, S. , Benz, F., Vargas Cardenas, D., Vucur, M., Gautheron, J., Schneider, A., Hellerbrand, C., Pottier, N., Alder, J., Tacke, F., Trautwein, C., Roderburg, C., Luedde, T. (2015): miR-30c and miR-193 are a part of the TGF-β-dependent regulatory network controlling extracellular matrix genes in liver fibrosis.. Journal of Digestive Diseases, 16 (9), 513-524, [1.887]
• Roderburg, C. , Benz, F., Cardenas, D.V., Lutz, M., Hippe, H.J., Luedde, T., Trautwein, C., Tacke, F., Luedde, M. (2015): Persistently elevated osteopontin serum levels predict mortality in critically ill patients.. Crit Care, 19, 271, [4.950]
• Roderburg, C. , Benz, F., Vargas Cardenas, D., Koch, A., Janssen, J., Vucur, M., Gautheron, J., Schneider, A.T., Koppe, C., Kreggenwinkel, K., Zimmermann, H.W., Luedde, M., Trautwein, C., Tacker F., Luedde, T. (2015): Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases.. Liver Int, 35 (4), 1182-1184, [4.470]
• Hammerich, L. (2015): CREMα overexpression impairs function of hepatic myeloid derived suppressor cells and aggravates immune-mediated hepatitis in mice.. Hepatology, [11.050]
• Benz, F. (2015): Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness.. Disease Markers, [1.560]
• Bartneck, M. (2015): Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases.. Biomaterials, [8.560]
• Tolba, R. H. , Kraus, T., Liedtke, C., Schwarz, M., Weiskirchen, R. (2015): Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice.. Laboratory Animals, 49(1), 59-69, [1.553]
• Scholten, D. , Trebicka, J., Liedtke, C., Weiskirchen, R. (2015): The carbon tetrachloride model in mice.. Laboratory Animals, 49(1), 4-11, [1.553]
• Boaru, S. G. , Borkham-Kamphorst, E., Van de Leur, E., Lehnen, E., Liedtke, C., Weiskirchen, R. (2015): NLRP3 inflammasome expression is driven by NF-kB in cultured hepatocytes.. Biochem Biophys Res Commun, 458, 700-706, [2.300]
• Tacke, F. , Roderburg, C., Benz, F., Cardenas, D. V., Luedde, M., Hippe, H. J., Frey, N., Vucur, M., Gautheron, J., Koch, A., Trautwein, C., Luedde, T. (2014): Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients.. Critocal Care Medicine, 42(5), 1096-1104, [7.422]
• Ehling, J. , Bartneck, M., Wie, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., Kiessling, F., Trautwein, C., Lammers, T., Tacke, F. (2014): CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.. Gut, 63(12), 1960-71, [14.921]
• Buendgens, L. , Bruensing, J., Matthes, M., Dückers, H., Luedde, T., Trautwein, C., Tacke, F., Koch, A. (2014): Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea. Journal of Critical Care, 29(4), 696, [2.445]
• Baeck, C. , Wie, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., Tacke, F. (2014): Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice.. Hepatology, 59(3), 1060-1072, [11.711]
• Hammerich, L. , Bangen, J. M., Govaere, O., Zimmermann, H. W., Gassler, N., Huss, S., Liedtke, C., Prinz, I., Lira, S. A., Luedde, T., Roskams, T., Trautwein, C., Heymann, F., Tacke, F. (2014): Chemokine receptor ccr6-dependent accumulation of gammadelta t cells in injured liver restricts hepatic inflammation and fibrosis.. Hepatology, 59(2), 630-642, [11.711]
• Borkham-Kamphorst E. , Schaffrath, C., van de Leur, E., Haas, U., Tihaa, L., Meurer, S. K., Nevzorova, Y. A., Liedtke, C., Weiskirchen, R. (2014): The anti-fibrotic effects of ccn1/cyr61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated tgf-beta signaling.. Biochim Biophys Acta, 1843(5), 902-914, [5.128]
• Zimmermann H. W. , Mueller, J. R., Seidler, S., Luedde, T., Trautwein, C., Tacke, F. (2013): Frequency and Phenotype of Human Circulating and Intrahepatic Natural Killer Cell Subsets Is Differentially Regulated according to Stage of Chronic Liver Disease.. Digestion, 88 (1), 1-16, [1.884]
• Vucur, M. , Reisinger, F., Gautheron, J., Janssen, J., Roderburg, C., Cardenas, D.V., Kreggenwinkel, K., Koppe, C., Hammerich, L., hakem, R., Unger, K., Weber, A., Gassler, N., Luedde, M., Frey, N., Neumann, U.P., Tacke, F., Trautwein, C., Heikenwalder, M., Luedde, T., (2013): RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation.. Cell Reports, 4 (4), 776-790, [7.780]
• Roderburg, C. , Luedde, M., Vargas Cardenas, D., Vucur, M., Mollnow, T., Zimmermann, H. W., Koch, A., Hellerbrand, C., Weiskirchen, R., Frey, N., Tacke, F., Trautwein, C., Luedde, T. (2013): miR-133a mediates TGF-ß-dependant derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. Journal of Hepatology, 58 (4), 736-742, [10.590]
• Roderburg, C. , Luedde, M., Vargas Cardenas, D., Vucur, M., Scholten, D., Frey, N., Koch, A., Trautwein, C., Tacke, F., Luedde, T. (2013): Circulating MicroRNA-150 Serum Levels Predict Survival in Patients with Critical Illness and Sepsis.. PLoS One, 8 (1), [3.057]
• Koch, A. , Weiskirchen, R., Kunze, J., Duckers, H., Bruensing, J., Buendgens, L., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.. Journal Critical Care, 28 (6), 947-953, [2.445]
• Koch, A. , Weiskirchen, R., Bruensing, J., Duckers, H., Buendgens, L., Kunze, J., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis.. Mediators of Inflammation, 2013, [3.418]
• Koch, A. , Buendgens, L., Duckers, H., Bruensing, J., Matthes, M., Kunze, J., Herbers, U., Lutz, H. H., Luedde, T., Tischendorf, J. J., Trautwein, C., Tacke, F. (2013): Gastrointestinal bleeding in liver cirrhosis at the ICU. Zeitschrift für Gastroenterologie, 51 (1), 19-25, [1.357]
• Koch, A. , Buendgens, L., Dückers, H., Bruensing, J., Matthes, M., Kunze, J., Llutz, H.H., Luedde, T., Tischendorf, J.J., Trautwein, C., Tacke, F. (2013): Bleeding origin, patient-related risk factors, and prognostic indicators in patients with acute gastrointestinal hemorrhages requiring intensive care treatment : A retrospective analysis from 1999 to 2010. Medizinische Klinik Intensivmedizin und Notfallmedizin, 108 (3), 214-222, [0.564]
• Herbers, U. , Amini-Bavil-Olyaee, S., Mueller, A., Luedde, T., Trautwein, C., Tacke, F. (2013): Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains. Journal of Viral Hepatology, 20 (2), 141-148, [4.179]
• Benz, F. , Roderburg, C., Cardenas, D.V., Vucur, M., Gautheron, J., Koch, A., Zimmermann, H., Janssen, J., Nieuwenhuijsen, L., Luedde, M., Frey, N., Tacke, F., Trautwein, C., Luedde, T. (2013): U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis.. Experimental & Molecular Medicine, 45 (9), [5.164]
• Nevzorova, Y. A. , Hu, W., Cubero, F. J., Haas, U., Freimuth, J., Tacke, F., Trautwein, C., Liedtke, C. (2013): Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis.. Biochimica et Biophysica Acta, 1832(10), 1765-75, [5.158]
• Sahin, H. , Borkham-Kamphorst, E., do, O. N., Berres, M. L., Kaldenbach, M., Schmitz, P., Weiskirchen, R., Liedtke, C., Streetz, K. L., Maedler, K., Trautwein, C., Wasmuth, H. E. (2013): Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.. Hepatology, 57 (2), 797-805, [11.711]
• Liedtke, C. , Luedde T, Sauerbruch T, Scholten D, Streetz K, Tacke F, Tolba R, Trautwein C, Trebicka J, Weiskirchen R. (2013): Experimental liver fibrosis research: Update on animal models, legal issues and translational aspects.. Fibrogenesis & Tissue Repair, 6(1), 19, [2.329]
• Cubero, F. J. , Singh, A., Borkham-Kamphorst, E., Nevzorova, Y. A., Al Masaoudi, M., Haas, U., Boekschoten, M. V., Gassler, N., Weiskirchen, R., Muller, M., Liedtke, C., Trautwein, C. (2013): Tnfr1 determines progression of chronic liver injury in the ikkgamma/nemo genetic model.. Cell Death & Differentiation, 20 (11), 1580-1592, [8.218]
• Hatting, M. , Zhao, G., Schumacher, F., Sellge, G., Al Masaoudi, M., Gabetaler, N., Boekschoten, M., Muller, M., Liedtke, C., Cubero, F. J., Trautwein, C. (2013): Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents.. Hepatology, 57 (69, 2189-2201, [11.711]
• Schneider, C. , Teufel, A., Yevsa, T., Staib, F., Hohmeyer, A., Walenda, G., Zimmermann, H. W., Vucur, M., Huss, S., Gassler, N., Wasmuth, H. E., Lira, S. A., Zender, L., Luedde, T., Trautwein, C., Tacke, F. (2012): Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. Gut, 61(12), 1733-43, [14.921]
• Roderburg, C. , Mollnow, T., Bongaerts, B., Elfimova, N., Vargas Cardenas, D., Berger, K., Zimmermann, H., Koch, A., Vucur, M., Luedde, M., Hellerbrand, C., Odenthal, M., Trautwein, C., Tacke, F., Luedde, T. (2012): Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. PLoS One, 7 (3), e32999, [3.057]
• Heymann, F. , Hammerich, L., Storch, D., Bartneck, M., Huss, S., Russeler, V., Gassler, N., Lira, S. A., Luedde, T., Trautwein, C., Tacke, F. (2012): Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology, 55 (3), 898-909, [11.711]
• Baeck, C. , Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., Trautwein, C., Tacke, F. (2012): Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut, 61 (3), 416-426, [14.921]
• Nevzorova, Y. A. , Bangen, J. M., Hu, W., Haas, U., Weiskirchen, R., Gassler, N., Huss, S., Tacke, F., Sicinski, P., Trautwein, C., Liedtke, C. (2012): Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice.. Hepatology, 56 (3), 1140-1149, [11.711]
• Zimmermann, H. W. , Seidler, S., Gassler, N., Nattermann, J., Luedde, T., Trautwein, C., Tacke, F. (2011): Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS One, 6 (6), e21381, [3.057]
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• Roderburg, C. , Trautwein, C., Luedde, T. (2011): MicroRNA-199a/b-3p: a new star in the liver microcosmos. Hepatology, 54, 729-731,
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• Luedde, T. (2010): MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma. Hepatology, 52 (3), 1164-1166, [11.711]
• Karlmark, K. R. , Zimmermann, H. W., Roderburg, C., Gassler, N., Wasmuth, H. E., Luedde, T., Trautwein, C., Tacke, F. (2010): The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology, 52 (5), 1769-1782, [11.711]
• Amini-Bavil-Olyaee, S. , Vucur, M., Luedde, T., Trautwein, C., Tacke, F. (2010): Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains. Journal of Virology, 84 (29, 1026-1033, [4.606]
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