P13 Prof. Dr. Weiskirchen
Targeting CCN1/CYR61 as a new treatment modality in hepatic fibrosis

In the present project, we will unravel the molecular pathways that are responsible for CCN1/CYR61-driven intracellular generation of reactive oxygen species, endoplasmic reticulum stress formation, and execution of cell-death pathways. The impact of CCN1/CYR61 on efferocytosis will be studied in primary hepatic cell subpopulations and in models of hepatic fibrogenesis. Together with clinical partners of the consortium, we will clarify if the observed experimental findings can be implemented in a more clinical setting and if transcriptional targeting approaches directing CCN1/CYR61 to profibrogenic cells is therapeutically effective. [...]

Publications

• Acharya P , Chouhan K., Weiskirchen S., Weiskirchen R. (2021): Cellular Mechanisms of Liver Fibrosis. frontiers in Pharmacology, 12, [5.330]
• Drescher H. K. , Schippers A., Rosenhain S., Gremse F., Bongiovanni L., de Bruin A., Eswaran S., Gallage S. U., Pfister D., Szydlowska M., Heikenwalder M., Weiskirchen S., Wagner N., Trautwein C., Weiskirchen R., Kroy D. C. (2020): L-Selectin/CD62L is a Key Driver of non-alcoholic Steatohepatitis in Mouse and Men. Cells, 9(5), 1106, [5.656]
• Azzam M. , El Safy S., Abdelgelil S. A., Weiskirchen R., Asimakopoulou A., de Lorenzi F., Lammers T., Mansour S., Tammam S. (2020): Targeting activated hepatic stellate cells using collagen-binding chitosan nanoparticles for siRNA delivery to fibrotic livers. Pharmaceutics, 12(6), 590, [4.773]
• Borkham-Kamphorst E. , Haas U., Van de Leur E., Trevanich A., Weiskirchen R. (2020): Chronic carbon tetra chloride applications induced hepatocyte apoptosis in Lipocaline 2 null mice through endoplasmic reticulum stress and unfolded protein response. International Journal of Molecular Sciences, 21(15), 5230, [4.183]
• Kim P. , Zhang C. C., Thoröe-Boveleth S., Weiskirchen S., Gaisa N. T., Buhl E. M., Stremmel W., Merle U., Weiskirchen R. (2020): Accurate Measurement of Copper Overload in an Experimental Model of Wilson Disease by Laser Ablation Inductively Coupled Plamsa Mass Spectrometry. Biomedicines, 8(9), 356, [3.600]
• Drescher H. K. , Bartsch L. M., Weiskirchen S., Weiskirchen R. (2020): Intrahepatic TH17/Treg cells in homeostasis and disease - it's all about balance. Front Pharmacol, 11, 588436, [3.845]
• Hermert D. , Martin I. V., Reiss L. K., Liu X., Breitkopf D. M., Reimer K. C., Alidousty C., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2020): The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis. Kidney International, 97(4), 741-752, [8.306]
• Weiskirchen S. , Weiper K., Tolba R. H., Weiskirchen R. (2020): All you can feed: Some comments on Production of mouse diets used in Biomedical Research with special emphasis on non-alcoholic fatty liver disease research. Nutrients, 12(1), 163,
• Yagmur E. , Otto S., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Decreased CTRP3 plasma concentrations are associated wtih sepsis and predict mortality in critically ill patients. Diagnostics, 9, 63, [2.489]
• Yagmur E. , Buergerhausen D., Koek G. H., Weiskirchen R., Trautwein C., Koch A., Tacke F. (2019): Elevated CTRP1 plasma concentration is associated with sepsis and pre-existing type 2 diabetes mellitus in critically ill patients. J Clin Med, 8, 661, [5.583]
• Yagmur E. , Bast E., Mühlfeld A. S., Koch A., Weiskirchen R., Tacke F., Neulen J. (2019): High prevalence of sticky platelet syndrome in patients with infertility and pregnancy loss. J Clin Med, 8, 1328, [5.583]
• Weiskirchen S. , Kim P., Weiskirchen R. (2019): Laser ablation inductively coupled plasma spectrometry: metal imaging in experimental and clinical Wilson Disease. Inorganics, 7, 54, [1.900]
• Weiskirchen S. , Kim P., Weiskirchen R. (2019): Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma spectrometry. Annals Transl Med, 7(2), 72, [3.689]
• Weiskirchen R. , Weiskirchen S., Tacke F. (2019): Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications. Mol Aspects Med, 65, 2-15, [10.238]
• Weiskirchen R. , Weiskirchen S., Kim P., Winkler R. (2019): Software solutions for evaluation and visualization of laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI) data: a short overview. J Cheminform, 11, 16, [4.154]
• Weiskirchen R. , Tacke F. (2019): Pathophysiologie: Immunologie.“ Nichtalkoholische Fettleber. (Eds. Andreas Geier, Ali Canbay & Frank Lammert). Springer Verlag, im Druck, [0.200]
• Weiskirchen R. , Tacke F. (2019): Hepatic fibrogenesis. Encyclopedia of Gastroenterology, 2nd Edition, Elsevier, New York, [0.200]
• Weiskirchen R. , Tacke F. (2019): Hepatic Fibrogenesis. Reference Module in Biomedical Sciences, , 1-7, [0.200]
• Weiskirchen R. , Tacke F. (2019): Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease. Cells, 8, 16, [5.656]
• Weiskirchen R. , Stremmel W. (2019): Wilson disease: current knowledge, challenges and perspectives. Preface to the Focused Issue “Wilson’s disease: from genetics to management of disease (Eds. Ralf Weiskirchen & Wolfgang Stremmel). Annals Transl Med, 7(2), 55, [3.689]
• van Roeyen C. R. C. , Martin I. V., Drescher A., Schuett K. A., Hermert D., Raffetseder U., Otten S., Buhl E. M., Braun G., Kuppe C., Liehn E., Boor P., Weiskirchen R., Eriksson U., Gross O., Eitner F., Floege J., Ostendorf T. (2019): Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int, 95, 1103-1119, [8.000]
• Sun Q. , Baues M., Klinkhammer B. M., Ehling J., Djudjaj S., Drude N. I., Daniel C., Amann K., Kramann R., Kim H., Saez-Rodriguez J., Weiskirchen R., Onthank D. C., Botnar R. M., Kiessling F., Floege J., Lammers T., Boor P. (2019): Elastin imaging enables non-invasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med, 11, 486, [17.161]
• Stremmel W. , Staffer S. G., Weiskirchen R. (2019): Phosphatidylcholine passes by paracellular transport to the apical side of the polarized biliary tumor cell line Mz-ChA-1. Int J Mol Sci, 20, 4034, [4.183]
• Stremmel W. , Merle U., Weiskirchen R. (2019): Clinical features of Wilson disease. Annals Transl Med, 7(2), 61, [3.689]
• Roderfeld M. , Padem S., Lichtenberger J., Quack T., Weiskirchen R., Longerich T., Schramm G., Churin Y., Irungbam K., Tschuschner A., Windhorst A., Grevelding C.G., Roeb E. (2019): Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes. Hepatology, 69, in press, [14.079]
• Pinheiro D. , Dias I., Silva K. R., Stumbo A. C., Thole A., Cortez E., de Carvalho L., Weiskirchen R., Carvalho S. (2019): Mechanisms underlying cell therapy in liver fibrosis: an overview. Cells, in press, [5.656]
• Meurer S.K. , Wimmer A.E., van de Leur E., Weiskirchen R. (2019): Endoglin trafficking/exosomal targeting in liver cells depends on N-glycosylation. Cells, 8, 997, [5.656]
• Mahli A. , Seitz T., Fresse K., Frank J., Weiskirchen R., Abdel-Tawab M., Behnam D., Hellerbrand C. (2019): Therapeutic application of micellar solubilized xanthohumol in a Western-type diet-induced mouse model of obesity, diabetes and non-alcoholic fatty liver disease. Cells, 8, 359, [5.656]
• Mahli A. , Seitz T., Beckröge T., Freese K., Thasler W.E., Benkert M., Dietrich P., Weiskirchen R., Bosserhoff A., Hellerbrand C. (2019): Bone morphogenetic protein-8B expression is induced in steatotic hepatocytes and promotes hepatic steatosis and inflammation in vitro. Cells, 8, 457, [5.656]
• Krenkel O. , Hundertmark J., Ritz T.P., Weiskirchen R., Tacke F. (2019): Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis. Cells, 8, 503, [5.656]
• Iwasaki J. , Afify M., Bleilevens C., Klinge U., Weiskirchen R., Steitz J., Vogt M., Yagi S., Nagai K., Uemoto S., Tolba R.H. (2019): The impact of a nitric oxide synthase inhibitor (L-NAME) on ischemia-reperfusion injury of cholestatic livers by Pringle Maneuver and liver resection after bile duct ligation in rats. Int J Mol Sci, 20, 2114, [4.183]
• Hermert D. , Martin I.V., Reiss L.K., Breitkopf D.M., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2019): YB-1-controlled CXCL-1 expression decides on kidney damage in liver fibrosis. Kidney Int, [8.395]
• Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D.C., Drescher H.K. (2019): The inhibitory T cell receptors PD1 and 2B4 are differentially regulated on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis. Front Pharmacol, 10, 244, [3.845]
• Drescher H. K. , Weiskirchen S., Weiskirchen R. (2019): Current status in testing for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cells, 8, 845, [5.656]
• Drescher H. K. , Weiskirchen R., Fülöp A., Hopf C., Gonzáles de San Roman E., Huesgen P.F., de Bruin A., Christ A., Tolba R., Trautwein C., Kroy D.C. (2019): The influence of different fat sources on steatohepatitis and fibrosis development in the Western diet mouse model of non-alcoholic steatohepatitis (NASH). Front Physiol, 10, 770, [3.394]
• Drescher H. K. , Brandt E. F., Fischer P., Dreschers S., Schwendener R. A., Kowalska M. A., Canbay A., Wasmuth H. E., Weiskirchen R., Trautwein C., Berres M. L., Kroy D. C., Sahin H. (2019): “.” 10, 326, [3.201] (2019): Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice. Front Physiol, 10, 326, [3.201]
• Borkham-Kamphorst E. , Van de Leur E., Haas U., Weiskirchen R. (2019): Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response. Cell Signal, 55, 90-99, [3.388]
• Asimakopoulou A. , Vucur M., Luedde T., Weiss T.S., Schneiders S., Kalampoka S., Weiskirchen R. (2019): Perilipin 5 and Lipocalin 2 expression in hepatocellular carcinoma. Cancers, 11(3), 385, [6.162]
• Yagmur E. , Buendgens L., Herbers U., Beeretz A., Weiskirchen R., Koek G. H., Trautwein C., Tacke F., Koch A. (2018): High mobility group box 1 as a biomarker in critically ill patients. J Clin Lab Anal, 32(8), e22584, [1.728]
• Weiskirchen S. , Weiskirchen R. (2018): A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS. Atlas of Science, December, [0.200]
• Weiskirchen R. , Tacke F. (2018): The role of radiologic modalities in diagnosing non-alcoholic steatohepatitis (NASH) and fibrosis. Curr Hepat Rep, 17, 324-335, [0.200]
• Ullmann P. , Rodriguez F., Schmitz M., Meurer S. K., Qureshi-Baig K., Felten P., Ginolhac A., Antunes L., Frasquilho S., Zügel N., Weiskirchen R., Haan S., Letellier E. (2018): The microRNA-371~373 cluster represses colon cancer initiation and metastatc colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Res, 78, 3793-3808, [8.378]
• Tacke F. , Weiskirchen R. (2018): An update on the recent advances in antifibrotic therapies. Exp Rev Gastroenterol Hepatol, 12(11), 1143-1152, [2.991]
• Sonntag R. , Giebeler N., Nevzorova Y. A., Bangen J. M., Fahrenkamp D., Lambertz D., Haas U., Hu W., Gassler N., Cubero F. J., Müller-Newen G., Abdallah A. T., Weiskirchen R., Ticconi F., Costa I. G., Barbacid M., Trautwein C., Liedtke C. (2018): Cyclin E1 and Cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma. Proc Natl Acad Sci USA, 115, 9282-9287, [9.580]
• Schröder S. K. , Asimakopoulou A., Weiskirchen R. (2018): Lipocalin 2 as a potential diagnostic and/or prognostic biomarker in prostate, lung and liver cancer. Clinics of Oncology, 1(3), 1-16, [0.200]
• Koch A. , Yagmur E., Linka J., Schumacher F., Bruensing J., Buendgens L., Herbers U., Koek G. H., Weiskirchen R., Trautwein C., Tacke F. (2018): High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients. Dis Markers, 8583121, [2.761]
• Koch A. , Yagmur E., Hoss A., Buendgens L., Herbers U., Weiskirchen R., Koek G. H., Trautwein C., Tacke F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J Clin Lab Anal, , e22614, [1.728]
• Kim P. , Weiskirchen S., Uerlings R., Kueppers A., Stellmacher F., Viveiros A., Zoller H., Weiskirchen R. (2018): Quantification of liver iron overload disease with laser ablation inductively coupled plasma mass spectrometry. BMC Med Imaging, 18, 51, [1.622]
• Gauthier A. , Fisch A., Seuwen K., Baumgarten B., Ruffner H., Aebi A., Rausch M., Bartneck M., Weiskirchen R., Tacke F., Storm G., Lammers T., Ludwig M.-G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials, 178, 481-495, [10.273]
• Borkham-Kamphorst E. , Steffen B. T., van de Leur E., Haas U., Weiskirchen R. (2018): Portal myofibroblasts are sensitive to CCN-mediated endoplasmic reticulum stress-related apoptosis with potential to attenuate biliary fibrogenesis. Cell Signal, 51, 72-85, [3.388]
• Yagmur, E. , Koch, A., Weiskirchen, R. Trautwein, C., Tacke, F. (2018): Clinical relevance of elevated high-mobility group box 1 (HMGB1) in critically ill patients. J. Clin. Lab. Anal., 33, e22614,
• Gauthier, A. , Fisch, A., Seuwen, K., Baumgarten, B., Ruffner, H., Aebi, A., Rausch, M., Bartneck, M., Weiskirchen, R., Tacke, F., Storm, G., Lammers, T., Ludwig, M. G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolutive phenotype in human primary macrophages to support healing of chronic wounds. Biomaterials, 04.006, in press,
• Koch, A. , Yagmur, E., Linka, J., Schumacher, F., Bruensing, J., Buendgens, L., Herbers, U., Koek, G. H., Weiskirchen, R., Trautwein, C., Tacke, F. (2018): High circulating caspase-cleaved keratin 18 fragments (M30) indicate short-term mortality in critically ill patients. Dis. Markers, 2018, 8583121,
• Schröder, S. K. , Asimakopoulou, A., Weiskirchen, R. (2018): Lipocalin 2 as a potential diagnostic and/or prognostic biomarker in prostate, lung and liver cancer. Clinics of Oncol., in press,
• Borkham-Kamphorst, E. , Van de Leur, E., Buhl, E. M., Meurer, S. K., Weiskirchen, R. (2018): N-glycosylation of Lipocalin 2 is not required for secretion or exosome targeting.. Front. Pharmacol., 9:426,
• Weiskirchen, R. , Weiskirchen, S., Tacke, F. (2018): Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications. Mol Aspects Med., , in press. doi: 10.1016/j.mam.2018.06.003,
• Weiskirchen, R. , Weiskirchen, S., Tacke, F. (2018): Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts. F1000, Res. 7, 921,
• Jenkitkasemwong, S. , Akinyode, N., Paulus, E., Weiskirchen, R., Hojyo, S., Fukada, T., Giraldo, G., Schrier, J., Garcia, A., Janus, C., Giasson, B., Knutson, M. D. (2018): SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc. Natl. Acad. Sci. U S A, 115, E1769-E1778,
• Lenk, L. , Pein, M., Will, O., Gomez, B., Viol, F., Hauser, C., Egberts, J.-H., Gundlach, P., Tiwari, S., Weiskirchen, R., Rose-John, S., Röcken, C., Mikulits, W., Wenzeli, P., Schneider, G., Saur, D., Schäfer, H., Sebens, S. (2018): The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. OncoImmunology, 7, e1368603,
• Ullmann, P. , Rodriguez, F., Schmitz, M., Meurer, S. K., Qureshi-Baig, K., Felten, P., Ginolhac, A., Antunes, L., Frasquilho, S., Zügel, N. Weiskirchen, R., Haan, S., Letellier, E. (2018): The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis. Cancer Res., in press,
• Krenkel, O. , Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., Weiskirchen, R., Longerich, T., Costa, I. G., Anstee, Q. M., Trautwein, C., Tacke, F. (2018): Therapeutic inhibition of inflammatory monocytes reduces steatohepatitis and liver fibrosis. Hepatology, 67, 1270-1283,
• Weiskirchen, S. , Weiskirchen, R. (2018): Ultrapure cells for liver research. Atlas of Science, May 30, 2018,
• Meurer, S. K. , Weiskirchen, R. (2018): Usage of Mitogen-Activated Protein Kinase small molecule inhibitors: more than just inhibition!. Front. Pharmacol., 9:98,
• Moreno, D. , Murillo, O., Gazquez, C., Hernandez-Alcoceba, R., Uerlings, R., Gonzalez-Aseguinolaza, G., Weiskirchen, R. (2018): Visualization of the therapeutic efficacy of a gene correction approach in Wilson's disease by laser-ablation inductively coupled mass spectrometry. J. Hepatol., 68, 199-201,
• Koch, A. , Yagmur, E., Hoss, A., Buendgens, L., Herbers, U., Weiskirchen, R., Koek, G. H., Trautwein, C., Tacke, F. (2018): Clinical relevance of copeptin plasma levels as a biomarker of disease severity and mortality in critically ill patients. J. Clin. Lab. Anal., in press., doi: 10.1002/jcla.22614,
• Uerlings, R. , Moreno D., Murillo, O., Gazquez, C., Hernandez-Alcoceba, R., Gonzalez-Aseguinolaza, G., Weiskirchen, R. (2018): Brain copper storage after long-term correction of Wilson's disease in a murine model of gene therapy. Neurol. Genet., 4, e243,
• Meurer, S. K. , Weiskirchen, R. (2018): Activation by Inhibition. Atlas of Science,
• Alsamman, M. , Sterzer, V., Meurer, S. K., Sahin, H., Schaeper, U., Kuscuoglu, D., Strnad, P., Weiskirchen, R., Trautwein, C., Scholten, D. (2018): Endoglin in human liver disease and murine models of liver fibrosis – a protective factor against liver fibrosis. Liver International, 38, 858-867, [4.470]
• Lambertz, J. , Berger, T., Mak, T.W., van Helden, J., Weiskirchen, R. (2017): Lipocalin-2 in Fructose-Induced Fatty Liver Disease. frontiers in Physiology, [4.031]
• Weiskirchen, S. , Weiskirchen R. (2017): Resveratrol: Is It Really Good for Liver Health?. Hepatitis Monthly, 17 (8), [1.932]
• Asimakopoulou A. , Borkham-Kamphorst E., Van de Leur E., Weiskirchen R. (2017): Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis. Data in Brief, August;13, 644-649, [0.200]
• Asimakopoulou A , Fülöp A., Borkham-Kamphorst E., de Leur E.V., Gassler N., Berger T., Beine B., Meyer H.E., Mak T.W., Hopf C., Henkel C., Weiskirchen R. (2017): "Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis.". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, (17) 30118-7, [5.158]
• Dietzel E. , Weiskirchen S., Floehr J., Horiguchi M., Todorovic V., Rifkin D.B., Jahnen-Dechent W., Weiskirchen R. (2017): Latent TGF-β binding protein-1 deficiency decreases female fertility. Biochemical and Biophysical Research Communications, 482(4), 1387-1392, [2.371]
• Meurer S.K. , Weiskirchen R. (2017): Endoglin (ENG). Encyclopedia of Signaling Molecules, 2nd Edition 2017 ISBN: 978-1-4419-0460-7, [0.200]
• Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F (2017): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44, [2.053]
• Uerlings, R. , Weiskirchen, R. (2017): An At-A-Glance Visualizatioon of Regional Metal Accretion in Tissue Samples via Image Overlay in Laser Ablation Inductively Coupled Plasma Mass Spectrometry. Laser Ablation: Advances in Research an Applications, Nova Science Publishers, 3, ISBN: 978-1-53612-408-8, [0.200]
• Weiskirchen R. (2017): Therapeutic targeting of the mitochondrial reactive oxygen species engine prevents portal hypertension and hepatic fibrogenesis. Liver International, 37 (7), 963-965, [4.470]
• Weiskirchen R. (2017): Fast progression of liver damage in lysosomal acid lipase deficiency. Current Medical Research and Opinion, [2.643]
• Weiskirchen R. , Tacke F. (2017): Interleukin-33 in the pathogenesis of liver fibrosis: alarming ILC2 and hepatic stellate cells. Cellular & Molecular Immunology, 14 (2), 143-145, [5.193]
• Weiskirchen S. , Tag C.G., Sauer-Lehnen S., Tacke F., Weiskirchen R. (2017): Isolation and culture of primary murine hepatic stellate cells. Methods in Molecular Biology, 1627, 165-191, [1.170]
• Weiskirchen R. , Tacke F. (2016): Liver fibrosis – which mechanisms matter?. Clinical Liver Disease, 8 (4), 94-99, [0.360]
• Uerlings R. , Matusch A., Weiskirchen R. (2016): Standardization and normalization of data from laser ablation inductively coupled plasma mass spectrometry. Laser Ablation (Ed. Yang D.). Intech Publishing. ISBN: 978-953-51-4892-0., [0.200]
• Schon H.-T. , Weiskirchen R. (2016): Exercise-induced release of pharmacologically active substances and their relevance for therapy of hepatic injury. Frontiers in Pharmacology, 7, 283, [4.418]
• Schon H.T. , Bartneck M., Borkham-Kamphorst E., Nattermann J., Lammers T., Tacke F., Weiskirchen R. (2016): Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis. Frontiers in Pharmacology, 7, 33, [4.418]
• Meurer S. K. , Weiskirchen R. (2016): Endoglin (ENG). Encyclopedia of Signaling Molecules, 2nd Edition (Springer), in press, [0.200]
• Koch A. , Weiskirchen R., Ludwig S., Buendgens L., Bruensing J., Yagmur E., Baeck C., Herbers U., Trautwein C., Tacke F. (2016): Relevance of serum sclerostin concentrations in critically ill patients. Journal of Critical Care, 37, 38-44,
• Koppe C. , Verheuged P., Gautheron J., Reisinger F., Kreggenwinkel K., Roderburg C., Quagliata L., Terracciano L., Gassler N., Tolba R., Boege Y., Weber A., Karin M., Luedde M., Neumann U. P., Weiskirchen R., Tacke F., Vucur M., Trautwein C., Lüscher B., Preisinger C., Heikenwälder M., Lüdde T. (2016): IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylation the cell death mediator RIPK1. Hepatology, 64 (4), 1217-1231, [11.711]
• Kanta J. , Mrkvicová A., Weiskirchen R. (2016): Editorial: Liver myofibroblasts. Frontiers in Physiology, 7, 343, [4.031]
• Borkham-Kamphorst E. , Steffen B. T., Van de Leur E., Tihaa L., Haas U., Weiskirchen R. (2016): Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response. BBA Mol Cell Res., 1863, 2604-2612, [5.128]
• Weiskirchen, R. , Tacke, F. (2016): Neue Therapieoptionen für die Leberfibrose: Aus der Forschung in die Klinik. New treatment options for liver fibrosis: From-bench-to-bedside.. Der Gastroenterologe, 11, 40-46, [0.200]
• Weiskirchen, R. , Tacke, F. (2016): Liver fibrosis: from pathogenesis to novel therapies.. Digestive Diseases and Sciences, 34, 410-422, [2.516]
• Weiskirchen, R. (2016): Intratumor heterogeneity, variability and plasticity: Questioning the current concepts in classification and treatment of hepatocellular carcinoma.. Hepatobiliary Surg Nutr, 5, 183-187, [3.050]
• Weiskirchen, R. (2016): Hepatoprotective and anti-fibrotic agents: It’s time to take the next step.. Frontiers in Pharmacology, 6, 303, [4.418]
• van Helden, J. , Weiskirchen, R. (2016): Diagnostischer Wert der quantitativen HBsAg Bestimmung bei der Hepatitis B Infektion (Diagnostic value of the quantitative HBsAg determination in hepatitis B infections).. Zeitschrift für Gastroenterologie, 54, 319-326, [1.357]
• Susnea, I. , Weiskirchen, R. (2016): Trace metal imaging in diagnostic of hepatic metal disease.. Mass Spectrometry Reviews, 35 (6), 666-686, [9.346]
• Uerlings, R , Matusch, A., Weiskirchen, R. (2016): Reconstruction of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) spatial distribution images in Microsoft Excel 2007.. Int J Mass Spectrom, 395, 27-35, [1.183]
• Buhl, E. M. , Djudjaj, S., Babickova, J., Klinkhammer, B. M., Folestad, E., Borkham-Kamphorst, E., Weiskirchen, R., Hudkins, K., Alpers, C. E., Eriksson, U., Floege, J., Boor, P. (2016): Role of PDGF-D in healthy and fibrotic kidneys.. Kidney Int, 89, 848-861, [7.683]
• Borkham-Kamphorst, , Weiskirchen, R. (2016): The PDGF system and its antagonists in liver fibrosis.. Cytokine Growth Factor Rev, 28C, 53-61, [6.571]
• Borkham-Kamphorst, E. , Steffen, B. T., van de Leur, E., Haas, U., Tihaa, L., Friedman, S. L., Weiskirchen, R. (2016): CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis.. Cell Signal, 28, 34-42, [4.191]
• Asimakopoulou, A. , Borkham-Kamphorst, E., Tacke, F., Weiskirchen, R. (2016): Lipocalin-2 (NGAL/LCN2), a "HELP-ME" signal in organ inflammation.. Hepatology, 63, 669-671, [11.711]
• Meurer S.K. , Neß M, Weiskirchen S, Kim P, Tag CG, Kauffmann M, Huber M, Weiskirchen R. (2016): Isolation of mature (peritoneum-derived) mast cells and immature (bone marrow-derived) mast cell precursors from mice. PLoS One, 11(6), e0158104, [3.057]
• Merle U. , Weiskirchen R. (2016): Wilson's disease: An inherited, silent, copper intoxication disease. Eur Med J. Neurol., 4:, 74-83, [1.920]
• Weiskirchen R. , Tacke F. (2016): Leberfibrose: von der Pathologie zu den Therapiemöglichkeiten. Falk Gastro-Kolleg., , 1-11, [0.200]
• Weiskirchen S. , Weiskirchen R. (2016): Resveratrol: How much wine do you have to drink to stay healthy?. Advances in Nutrition, 7, 706-718, [5.201]
• Weiskirchen, R. , Tacke, F. (2015): Small heterodimer partner (SHP) links hepatitis C and liver fibrosis: a small protein on the big stage. Liver Int, 35, 2218-2221, [4.470]
• van Helden, J. , Weiskirchen, R. (2015): Experience with the first fully automated chemiluminescence immunoassay for the quantification of 1α, 25-Dihydroxy-Vitamin D. Clin Chem Lab Med, 53, 761-770, [3.017]
• Wallace, M. C., , Hamesch, K., Lunova, M., Kim, Y., Weiskirchen, R., Strnad, P., Friedman, S. L. (2015): Standard Operating Procedures in experimental liver research: Thioacetamide model in mice. Laboratory Animals, 49(1), 59-69, [1.120]
• Tolba, R. H. , Riediger, B. M., Weiskirchen, R. (2015): Standard Operating Procedures in experimental liver research: time to achieve uniformity. Lab Animals, 49(S1), 21-29, [1.553]
• Tolba, R. H. , Kraus, T., Liedtke, C., Schwarz, M., Weiskirchen, R. (2015): Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice.. Laboratory Animals, 49(1), 59-69, [1.553]
• Tag, C. G , Sauer-Lehnen, S., Weiskirchen, S., Borkham-Kamphorst, E., Tolba, R. H., Tacke, F., Weiskirchen, R. (2015): Bile duct ligation in mice: Induction of inflammatory liver injury and fibrosis by obstructive cholestasis.. Journal of Visualized Experiments, 96, e52438, [1.240]
• Tag, C. G. , Weiskirchen, S. K., Hittatiya, K., Tacke, F., Tolba, R. H., Weiskirchen, R. (2015): Induction of experimental obstructive cholestasis in mice.. Laboratory Animals, 49(1), 70-80, [1.553]
• Scholten, D. , Trebicka, J., Liedtke, C., Weiskirchen, R. (2015): The carbon tetrachloride model in mice.. Laboratory Animals, 49(1), 4-11, [1.553]
• Ramadori, P , Weiskirchen, R., Trebicka, J., Streetz, K. (2015): Mouse models of metabolic liver injury.. Lab Animals, 49(S1), 47-58., [1.553]
• Horiguchi, M. , Todorovic, V., Hadjiolova, K., Weiskirchen, R., Rifkin, D. B. (2015): Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal. Matrix Biol, 41, 61-70, [4.470]
• Heymann, F. , Hamesch, K., Weiskirchen, R., Tacke, F. (2015): The Concanavalin A model of acute hepatitis in mice.. Lab Anim, 49(S1), 12-20., [1.120]
• Hamesch, K. , Borkham-Kamphorst, E., Strnad, P., Weiskirchen, R. (2015): Lipopolysaccharide-induced inflammatory liver injury in mice.. Lab Anim, 49(S1), 37-46, [1.120]
• Borkham-Kamphorst, E. , Meurer, S. K., Van de Leur, E., Haas, U., Tihaa, L., Weiskirchen, R. (2015): PDGF-D signalling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β.. Cell Signal, 27, 1305-1314, [4.320]
• Borkham-Kamphorst, E. , Alexi, P., Tihaa, L., Haas, U., Weiskirchen, R. (2015): Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.. Biochem Biophys Res, Commun 457, 307-313, [2.300]
• Boaru, S. G. , Borkham-Kamphorst, E., Van de Leur, E., Lehnen, E., Liedtke, C., Weiskirchen, R. (2015): NLRP3 inflammasome expression is driven by NF-kB in cultured hepatocytes.. Biochem Biophys Res Commun, 458, 700-706, [2.300]
• Boaru, S. G. , Merle, U., Uerlings, R., Zimmermann, A., Willheim, C., Ferenci, P., Stremmel, W., Weiskirchen, R. (2015): Laser ablation inductively coupled plasma mass spectrometry imaging of metals in experimental and clinical Wilson's disease.. J Cell Mol Med, 19, 806-814, [4.010]
• Bartneck, M. , Warzecha, K. T., Tag, C. G., Sauer-Lehnen, S., Heymann, F., Trautwein, C., Weiskirchen, R., Tacke, F. (2015): Isolation and time lapse microscopy of highly pure hepatic stellate cells.. Anal Cell Pathol (Amst), Article ID-417023, [0.850]
• Bartneck, M. , Topuz, F., Tag, C. G., Sauer-Lehnen, S., Warzecha, C. T., Trautwein, C., Weiskirchen, R., Tacke, F. (2015): Molecular response of liver sinusoidal endothelial cells on hydrogels. Mater Sci Eng C Mater Biol, Appl 51, 64-72, [3.420]
• Asimakopoulou, A. (2015): Lipocalin 2 in the pathogenesis of fatty liver disease and non-alcoholic steatohepatitis.. Clin. Lipidol, 10, 47-67, [0.870]
• Uerlings, R. , Weiskirchen, R. (2015): Laser ablation inductively coupled plasma mass spectrometry in biomedicine and clinical diagnosis.. Cellular & Molecular Medicine, open access 1, 1:-1, [5.193]
• Winkler, S. , Borkham-Kamphorst, E., Stock, P., Brückner, S., Weiskirchen, R., Christ, B. (2014): Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model.. Experimental Cell Research, 326 (2), 230-239, [3.930]
• Weiskirchen, R. , Tacke, F. (2014): Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology.. Hepatobiliary Surgery and Nutrition, 3 (6), 344-363, [3.050]
• van Helden , J. , Weiskirchen, R (2014): Hepatitis C diagnostics: clinical evaluation of the HCV-core antigen determination (Hepatitis C Diagnostik: Klinische Evaluierung der HCV-core Antigen Bestimmung). Zeitschrift für Gastroenterologie, 52(10), 1164-1170, [1.357]
• Tacke, F. , Weiskirchen, R. (2014): Liver immunology: new perspectives. Hepatobiliary Surg Nutr, 3 (6), 330, [3.050]
• Schon, H. T , Weiskirchen, R. (2014): Immunmodulatory effects of transforming growth factor-β in the liver.. Hepatobiliary Surgery and Nutrition, 3, 386-406, [3.050]
• Meurer, S. K. , Alsamman, M., Scholten, D., Weiskirchen, R. (2014): Endoglin in liver fibrogenesis – Bridging basic science and clinical practice.. World J. Biol Chem, 5(2), 180-203,
• Martinez-Palacian, A. , Martinez-Palacian, A., Kanse, S. M., Weiskirchen, R. (2014): Factor VII activating protease (FSAP): A novel protective factor in liver fibrosis. Proteomics Clinical Applications, 8(5-6), 438-446, [2.959]
• Koch, A. , Zimmermann, H. W., Gassler, N., Jochum, C., Weiskirchen, R., Bruensing, J., Buendgens, L., Dückers, H., Bruns, T., Gerken, G., Neumann, U. P., Adams, D. H., Trautwein, C., Canbay, A., Tacke, F. (2014): Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure.. Liver International, 34(9), 13301339, [4.470]
• Bultmann, C. A. , Weiskirchen, R. (2014): MAKERGAUL: An innovative MAK-based model and software for real-time PCR quantification.. Clin Biochem, 47(1-2), 117-122, [2.382]
• Borkham-Kamphorst E. , Schaffrath, C., van de Leur, E., Haas, U., Tihaa, L., Meurer, S. K., Nevzorova, Y. A., Liedtke, C., Weiskirchen, R. (2014): The anti-fibrotic effects of ccn1/cyr61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated tgf-beta signaling.. Biochim Biophys Acta, 1843(5), 902-914, [5.128]
• Boaru, S. G. , Merle, U., Uerlings, R., Zimmermann, A., Weiskirchen, S., Stremmel, W., Weiskirchen, R. (2014): Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometry.. BMC Neuroscience, , 15-98., [2.304]
• Asimakopoulou, A. , Borkham-Kamphorst, E., Henning, M., Yagmur, E., Gassler, N., Berger, T., Mak, T. W., Weiskirchen, R. (2014): Lipocalin 2 (LCN2) regulates OXPAT expression and intracellular lipid droplet formation in the liver.. BBA Mol Cell Biol Lipids, 1841 (10), 1513-1524, [4.779]
• Abnaof, K. , Mallela, N., Vinoid, N., Walenda, G., Meurer, S. K., Seré, K., Lin, Q., Smeets, B., Hoffmann, K., Wagner, W., Zenke, M., Weiskirchen, R., Fröhlich, H. (2014): TGF-beta stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level. BMC Systems Biol, 8, 55, [2.208]
• Weiskirchen, R. , Weimer, J., Meurer, S. K., Kron, A., Seipel, B., Vater, I., Arnold, N., Siebert, R., Xu, L., Friedman, S. L., Bergmann, C. (2013): Genetic characteristics of the human hepatic stellate cell line LX-2.. PLoS One, 8 (10), [3.057]
• Weiskirchen, R. , Meurer, S. K. (2013): BMP-7 counteracting TGF-beta1 activities in organ fibrosis. Frontiers in Bioscience (Landmark Ed), 18, 1407-1434, [2.484]
• Sahin, H. , Borkham-Kamphorst, E., do, O. N., Berres, M. L., Kaldenbach, M., Schmitz, P., Weiskirchen, R., Liedtke, C., Streetz, K. L., Maedler, K., Trautwein, C., Wasmuth, H. E. (2013): Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.. Hepatology, 57 (2), 797-805, [11.711]
• Roderburg, C. , Luedde, M., Vargas Cardenas, D., Vucur, M., Mollnow, T., Zimmermann, H. W., Koch, A., Hellerbrand, C., Weiskirchen, R., Frey, N., Tacke, F., Trautwein, C., Luedde, T. (2013): miR-133a mediates TGF-ß-dependant derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. Journal of Hepatology, 58 (4), 736-742, [10.590]
• M-M, P. , Weiskirchen, R., Gassler, N., Bosserhoff, A. K., Becker, J. S. (2013): Novel bioimaging techniques of metals by laser ablation inductively coupled plasma mass spectrometry for diagnosis of fibrotic and cirrhotic liver disorders.. PLoS One, 8 (3), [3.057]
• Meurer, S. K. , Alsamman, M., Sahin, H., Wasmuth, H. E., Kisseleva, T., Brenner, D. A., Trautwein, C., Weiskirchen, R., Scholten, D. (2013): Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line.. PLoS One, 8 (2), [3.057]
• Martin, I. V. , Borkham-Kamphorst E, Zok S, van Roeyen CRC, Eriksson U, Boor P, Hiththetiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T. (2013): Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis. The American Journal of Pathology, 182 (1), 107-117, [4.206]
• Labbus, K. , Henning, M., Borkham-Kamphorst, E., Geisler, C., Berger, T., Mak, T. W., Knuchel, R., Meyer, H. E., Weiskirchen, R., Henkel, C. (2013): Proteomic profiling in Lipocalin 2 deficient mice under normal and inflammatory conditions.. Journal of Proteomics, 78, 188-196, [3.867]
• Koch, A. , Weiskirchen, R., Kunze, J., Duckers, H., Bruensing, J., Buendgens, L., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.. Journal Critical Care, 28 (6), 947-953, [2.445]
• Koch, A. , Weiskirchen, R., Bruensing, J., Duckers, H., Buendgens, L., Kunze, J., Matthes, M., Luedde, T., Trautwein, C., Tacke, F. (2013): Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis.. Mediators of Inflammation, 2013, [3.418]
• Huss, S. , Stellmacher, C., Goltz, D., Khlistunova, I., Adam, A. C., Trebicka, J., Kirfel, J., Buttner, R., Weiskirchen, R. (2013): Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice.. BMC Gastroenterology, 13, 8, [2.101]
• Cubero, F. J. , Singh, A., Borkham-Kamphorst, E., Nevzorova, Y. A., Al Masaoudi, M., Haas, U., Boekschoten, M. V., Gassler, N., Weiskirchen, R., Muller, M., Liedtke, C., Trautwein, C. (2013): Tnfr1 determines progression of chronic liver injury in the ikkgamma/nemo genetic model.. Cell Death & Differentiation, 20 (11), 1580-1592, [8.218]
• Borkham-Kamphorst, E. , Zimmermann, H. W., Gassler, N., Bissels, U., Bosio, A., Tacke, F., Weiskirchen, R., Kanse, S. M. (2013): Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.. Journal of Hepatology, 58 (1), 104-111, [10.590]
• Borkham-Kamphorst, E. , van de Leur, E., Zimmermann, H.W., Karlmark, K.R., Tihaa, L., Haas, U., Tacke, F., Berger, T., Mak, T.W., Weiskirchen, R., (2013): Protective effects of Lipocalin-2 (LCN2) in acute and chronic liver injury suggesting a novel function in liver homeostasis.. BBA Molecular Basis of Disease, 1832 (5), 660-73, [5.128]
• Seidler, S. , Zimmermann, H. W., Weiskirchen, R., Trautwein, C., Tacke, F. (2012): Elevated circulating soluble interleukin-2 receptor in patients with chronic liver diseases is associated with non-classical monocytes. BMC Gastroenterology, 12, 38, [2.101]
• Tacke, F. , Weiskirchen, R. (2012): Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques. Expert Review of Gastroenterology Hepatology, 6, 67-80, [2.796]
• van Roeyen CRC, Boor P. , Borkham-Kamphorst E, Rong S, Kunter U, Martin IV, Kaitovic A, Fleckenstein S, Perbal B, Weiskirchen R, Ostendorf T, Floege J. (2012): A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and anti-mesangioproliferative effects. American Journal of Pathology, 180, 1979-1990, [4.206]
• Sahin, H. , Borkham-Kamphorst, E., Kuppe, C., Zaldivar, M. M., Grouls, C., Al-Samman, M., Nellen, A., Schmitz, P., Heinrichs, D., Berres, M. L., Doleschel, D., Scholten, D., Weiskirchen, R., Moeller, M. J., Kiessling, F., Trautwein, C., Wasmuth, H. E. (2012): Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology, 55 (5), 1610-1619, [11.711]
• Roderburg, C. , Mollnow, T., Bongaerts, B., Elfimova, N., Vargas Cardenas, D., Berger, K., Zimmermann, H., Koch, A., Vucur, M., Luedde, M., Hellerbrand, C., Odenthal, M., Trautwein, C., Tacke, F., Luedde, T. (2012): Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis. PLoS One, 7 (3), e32999, [3.057]
• Reichenbach, V. , Fernandez-Varo, G., Casals, G., Oro, D., Ros, J., Melgar-Lesmes, P., Weiskirchen, R., Morales-Ruiz, M.W., Jimenez, W. (2012): Transduction of the liver with dominant-negative soluble PDGFRbeta improves systemic hemodynamics, portal pressure and fibrosis in CCl4-treated rats. Journal of Hepatology, 57, 967-973, [10.590]
• Parahuleva, M. S. , Holschermann, H., Zandt, D., Pons-Kuhnemann, J., Parviz, B., Weiskirchen, R., Staubitz, A., Tillmanns, H., Erdogan, A., Kanse, S. M. (2012): Circulating factor VII activating protease (FSAP) is associated with clinical outcome in acute coronary syndrome. Circulation Journal, 76, 2653-2661, [4.124]
• Nevzorova, Y. A. , Bangen, J. M., Hu, W., Haas, U., Weiskirchen, R., Gassler, N., Huss, S., Tacke, F., Sicinski, P., Trautwein, C., Liedtke, C. (2012): Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice.. Hepatology, 56 (3), 1140-1149, [11.711]
• Meurer, S. K. , Esser, M., Tihaa, L., Weiskirchen, R. (2012): BMP-7/TGF-beta1 signalling in myoblasts: Components involved in signalling and BMP-7-dependent blockage of TGF-beta-mediated CTGF expression. European Journal of Cell Biology, 91, 450-463, [4.011]
• Borkham-Kamphorst, E. , van Roeyen, C. R., Van de Leur, E., Floege, J., Weiskirchen, R. (2012): CCN3/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. Journal of Cell Communication and Signaling, 6, 11-25, [3.123]
• Borkham-Kamphorst, E. , Huss, S., Van de Leur, E., Haas, U., Weiskirchen, R. (2012): Adenoviral CCN3/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis. Liverer International, 32 (9), 1342-1353, [4.470]
• Boaru, S. G. , Borkham-Kamphorst, E., Tihaa, L., Haas, U., Weiskirchen, R. (2012): Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease. Journal of Inflammation (Lond), 9, 49. 2012, [1.975]
• Bergmann, C. , Weiskirchen, R. (2012): It's not all in the cilium, but on the road to it: Genetic interaction network in polycystic kidney and liver diseases and how trafficking and quality control matter. Journal of Hepatology, 56, 1201-1203, [10.590]
• Borkham-Kamphorst, E. , Drews, F., Weiskirchen, R. (2011): Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1beta through nuclear factor-kappaB activation. Liver International, 31 (5), 656-665, [4.470]
• Weiskirchen, R. (2011): CCN proteins in normal and injured liver. Frontiers in Bioscience, 16, 1939-1961, [2.484]
• Scholten, D. , Weiskirchen, R. (2011): Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury. Hepatology, 53 (3), 1048-1051, [11.711]
• Rauen, T. , Weiskirchen, R., Floege, J. (2011): In search of early events in the development of chronic kidney disease: the emerging role for lipocalin-2/NGAL. Nephrology Dialysis Transplantation, 26, 445-447, [4.085]
• Pieper-Furst, U. , Hall, R., Huss, S., Hochrath, K., Fischer, H. P., Tacke, F., Weiskirchen, R., Lammert, F. (2011): Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. Biochimica et Biophysica Acta, 1812 (12), 1640-1648, [5.158]
• Meurer, S. K. , Tihaa, L., Borkham-Kamphorst, E., Weiskirchen, R. (2011): Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. Cellular Signalling, 23 (4), 683-699, [4.191]
• Henkel, C. , Schwamborn, K., Zimmermann, H. W., Tacke, F., Kuhnen, E., Odenthal, M., Groseclose, M. R., Caprioli, R. M., Weiskirchen, R. (2011): From proteomic multimarker profiling to interesting proteins: thymosin-beta(4) and kininogen-1 as new potential biomarkers for inflammatory hepatic lesions. Journal of Cellular an Molecular Medicine, 15 (10), 2176-2188, [4.938]
• Hellerbrand, C. , Weiskirchen, R. (2011): Does it matter not only how much but also when we eat to induce fatty liver?. Hepatology, 54 (3), 1096-1099, [11.711]
• Zaldivar, M. M. , Pauels, K., von Hundelshausen, P., Berres, M. L., Schmitz, P., Bornemann, J., Kowalska, M. A., Gassler, N., Streetz, K. L., Weiskirchen, R., Trautwein, C., Weber, C., Wasmuth, H. E. (2010): CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology, 51 (4), 1345-1353, [11.711]
• Zimmermann, H. W. , Seidler, S., Nattermann, J., Gassler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J., Luedde, T., Weiskirchen, R., Trautwein, C., Tacke, F. (2010): Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One, 5 (6), e11049, [3.057]
• Wasmuth, H. E. , Weiskirchen, R. (2010): Pathogenesis of liver fibrosis: modulation of stellate cells by chemokines. Zeitschrift für Gastroenterologie, 48 (1), 38-45, [1.357]
• Wasmuth, H. E. , Weiskirchen, R. (2010): Personalized medicine in hepatitis C: from genome-wide association studies to clinical practice. Hepatology, 51 (6), 2223-2225, [11.711]
• Tacke F , Weiskirchen R. (2010): Liver fibrosis - pathogenesis and novel therapeutic approaches. Der Internist, 51 (1), 21-29, [0.336]
• Koch, A. , Weiskirchen, R., Zimmermann, H. W., Sanson, E., Trautwein, C., Tacke, F. (2010): Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators of Inflammation, [3.418]
• Koch, A. , Weiskirchen, R., Sanson, E., Zimmermann, H. W., Voigt, S., Duckers, H., Trautwein, C., Tacke, F. (2010): Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation. Crit Care, 14, R179, [4.950]
• Huss, S. , Schmitz, J., Goltz, D., Fischer, H. P., Buttner, R., Weiskirchen, R. (2010): Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis. Fibrogenesis Tissue Repair, 3, 10, [2.329]
• Bomble, M. , Tacke, F., Rink, L., Kovalenko, E., Weiskirchen, R. (2010): Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts. Biochem Biophys Res Commun, 396, 342-347, [2.371]
• Bohr, W. , Kupper, M., Hoffmann, K., Weiskirchen, R. (2010): Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein. PLoS One, 5 (12), e16000, [3.057]
• Berres, M. L. , Koenen, R. R., Rueland, A., Zaldivar, M. M., Heinrichs, D., Sahin, H., Schmitz, P., Streetz, K. L., Berg, T., Gassler, N., Weiskirchen, R., Proudfoot, A., Weber, C., Trautwein, C., Wasmuth, H. E. (2010): Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. Journal of Clinical Investigation, 120 (11), 4129-4140, [12.575]
• Bettermann, K. , Vucur, M., Haybaeck, J., Koppe, C., Janssen, J., Heymann, F., Weber, A., Weiskirchen, R., Liedtke, C., Gassler, N., Muller, M., de Vos, R., Wolf, M. J., Boege, Y., Seleznik, G. M., Zeller, N., Erny, D., Fuchs, T., Zoller, S., Cairo, S., Buendia, M. A., Prinz, M., Akira, S., Tacke, F., Heikenwalder, M., Trautwein, C., Luedde, T. (2010): TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell, 17 (5), 481-496, [23.214]
• Weiskirchen, R. , Wasmuth, H. E. (2009): The genes that underlie fatty liver disease: the harvest has begun. Hepatology, 49, 692-694,
• Weiskirchen, R. , Liedtke, C., Trautwein, C. (2009): When sleeping beauty wakes up and jumps into a cancer-minded environment. Hepatology, 49, 2122-2124., [11.711]
• Wasmuth, H. E , Tag, C. G., Van de Leur, E., Hellerbrand, C., Mueller, T., Berg, T., Puhl, G., Neuhaus, P., Samuel, D., Trautwein, C., Kanse, S. M., Weiskirchen, R. (2009): The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.. Hepatology, 49, 775-780, [11.711]
• Wasmuth, H. E. , Lammert, F., Zaldivar, M. M., Weiskirchen, R., Hellerbrand, C., Scholten, D., Berres, M. L., Zimmermann, H., Streetz, K. L., Tacke, F., Hillebrandt, S., Schmitz, P., Keppeler, H., Berg, T., Dahl, E., Gassler, N., Friedman, S. L., Trautwein, C. (2009): Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.. Gastroenterology, 137, 309-319, 301-303, [18.187]
• Kovalenko, E. , Tacke, F., Gressner, O. A., Zimmermann, H. W., Lahme, B., Janetzko, A., Wiederholt, T., Berg, T., Muller, T., Trautwein, C., Gressner, A. M., Weiskirchen, R. (2009): Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis.. J Viral Hepat, 16, 612-620, [4.179]
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