P25 Prof. Dr. Boor/Prof. Dr. Floege
Cell-specific role of the PDGF system in renal fibrosis

We aim to analyse the role of PDGF-BB, the ligand of both PDGF receptor chains α and β, in progressive kidney diseases using genetic deletion of PDGF-B in a cell-specific manner. We also aim to clarify the role of PDGFR signaling in the perivascular Gli1+ precursors of renal, but also liver myofibroblasts using mice with inducible activation of constitutively active PDGFR mutants specifically in Gli1+ cells. Finally, we aim to evaluate the components of the PDGF system as potential biomarkers or molecular imaging modalities for the non-invasive assessment of renal fibrosis.