P17 Prof. Dr. Möller/Prof. Dr. Ostendorf
Parietal epithelial cell activation and glomerulosclerosis: Mechanisms, mediators and clinical diagnosis

Building on our progress from the first funding periods, we will investigate the molecular and biophysical mechanism of glomerular hyperfiltration and glomerular hypertrophy as independent risk factors for parietal cell (PEC) activation and induction of glomerulosclerosis (FSGS). To improve diagnosis, we will identify and characterize novel biomarkers for PEC activation and single nephron glomerular filtration rate (SNGFR) in renal biopsies and in urine, respectively. Finally, we and others have identified an additional reservoir of podocytes on Bowman’s capsule in newborn mammals. We will investigate whether recruitment of podocytes from this reservoir is regulated and whether it can be enhanced. [...]

Publications

• Klinkhammer B. M. , Djudjaj S., Kunter U., Palsson R., Edvardsson V. O., Wiech T., Thorsteinsdottir M., Hardarson S., Foresto-Neto O., Mulay S. R., Moeller M. J., Jahnen-Dechent W., Floege J., Anders H.J., Boor P. (2020): Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy. Journal of American Society of Nephrology, 31(4), 799-816, [8.491]
• Breitkopf D. M. , Jankowski V., Ohl K., Hermann J., Hermert D., Tenbrock K., Liu X., Martin I. V., Wang J., Groll F., Gröne E., Floege J., Ostendorf T., Rauen T., Raffetseder U. (2020): TheYB-q: Notch-3 axis modulates immune cell responses and organ damage in systemic tupus erythematosus. Kidney International, 97(2), 289-303, [8.306]
• Hermert D. , Martin I. V., Reiss L. K., Liu X., Breitkopf D. M., Reimer K. C., Alidousty C., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2020): The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis. Kidney International, 97(4), 741-752, [8.306]
• van Roeyen C. R. C. , Martin I. V., Drescher A., Schuett K. A., Hermert D., Raffetseder U., Otten S., Buhl E. M., Braun G., Kuppe C., Liehn E., Boor P., Weiskirchen R., Eriksson U., Gross O., Eitner F., Floege J., Ostendorf T. (2019): Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int, 95, 1103-1119, [8.000]
• Puelles V. G. , Fleck D., Ortz L., Papadouri S., Strieder T., Boehner A., van der Wolde J. W., Vogt M., Saritas T., Kuppe C., Fuss A., Menzel S., Klinkhammer B. M., Müller-Newen G., Heymann F., Decker L., Braun F., Kretz O., Huber T. B., Susaki E. A., Ueda H. R., Boor P., Floege J., Kramann R., Kurts C., Bertram J. F., Spehr M., Nikolic-Paterson D. J., Moeller M. J. (2019): 3D analysis of rapidly progressive glomerulonephritis using optical tissue clearing. Kidney Int, 96, 505-516, [8.306]
• Laurentius T. , Raffetseder U., Fellner C., Kob R., Nourbakhsh M., Floege J., Bertsch T., Bollheimer L. C., Ostendorf T. (2019): High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats. J Inflamm (Lond), 16, 14 eCollection, [2.662]
• Kuppe C. , Leuchtle K., Wagner A., Kabgani N., Saritas T., Puelles V. G., Smeets B., Hakroush S., van der Vlag J., Buhl E. M., Boor P., Schiffer M., Gröne H. J., Fogo A., Floege J., Moeller M. J. (2019): Novel parietal epithelial cell subpopulations in FSGS and the origin of the glomerular tip lesion. Kidney Int, 96, 80-93, [8.306]
• Kuppe C. , Gröne H.-J., Ostendorf T, van Kuppevelt T. H., Boor P., Floege J., Smeets B., Moeller M. J. (2019): Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis. Kidney International, [8.306]
• Hermert D. , Martin I.V., Reiss L.K., Breitkopf D.M., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2019): YB-1-controlled CXCL-1 expression decides on kidney damage in liver fibrosis. Kidney Int, [8.395]
• Breitkopf D. M. , Jankowski V., Ohl K., Hermann J., Hermert D., Tenbrock K., Liu X., Martin I. V., Wang J., Groll F., Gröne E., Floege J., Ostendorf T., Rauen T., Raffetseder U. (2019): The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus. Kidney Int, in press, [8.306]
• Martin I. V. , Bohner A., Boor P., Shagdarsuren E., Raffetseder U., Lammert F., Floege J., Ostendorf T., Weber S. N. (2018): Complement C5a receptors C5L2 and C5aR in renal fibrosis. Am J Physiol Renal Physiol, 314, F35-F46, [3.611]
• Gibbert L. , Hermert D., Wang J., Breitkopf D. M., Alidousty C., Neusser M., Cohen C. D., Gröne E., Macheleidt I., Rauen T., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2018): YB-1 increases glomerular, but decreases interstitial fibrosis in CNI-induced nephropathy. Clin Immunol, 194, 67-74, [3.557]
• Eymael J. , Sharma S., Loeven M. A., Wetzels J. F., Mooren F., Florquin S., Deegens J. K., Willemsen B. K., Sharma V., van Kuppevelt T. H., Bakker M. A., Ostendorf T., Moeller M. J., Dijkman H. B., Smeets B., van der Vlag J. (2018): CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis. Kidney Int, 93, 626-642, [8.429]
• Martin, I.V. , Bohner, A., Boor, P., Shagdarsuren, E., Raffetseder, U., Lammert, F., Floege, J., Ostendorf, T., Weber, S.N. (2017): Complement C5a receptors C5L2 and C5aR in renal fibrosis. American Journal of Physiology, 314 (1), 35-46, [27.312]
• Wang, J. , Djudjaj, S., Gibbert, L., Lennartz, V., Breitkopf, D., Rauen, T., Hermert, D., Martin, I.V., Boor, P., Braun, G.S., Floege, J., Ostendorf, T., Raffetseder, U. (2017): YB-1 mediates both, onset an resolution of inflammation. Journal of Cellular and Molecular Medicine, [5.090]
• Wang J. , Gibbert L., Djudjaj S., Alidousty C., Rauen T., Kunter U., Rembiak A., Enders D., Jankowski V., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2016): Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis. Kidney Int, 90, 1226-1237, [8.395]
• Wang J. , Gibbert L., Djudjaj S., Alidousty C., Rauen T., Kunter U., Rembiak A., Enders D., Jankowski V., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2016): Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis. Kidney Int, 90, 1226-1237, [8.395]
• Djudjaj, S. , Lue, H. J., Rong, S., Papasotiriou, M., Klinkhammer, B. M., Zok, S., Klaener, O., Braun, G. S., Lindenmeyer, M. T., Cohen, C. D., Bucala, R., Tittel, A. P., Kurts, C., Moeller, M. J., Floege, J., Boor, P. (2016): Macrophage migration inhibitory factor mediates proliferative glomerulonephritis via CD74. Journal of the American Society of Nephrology, 27 (6), 1650-1664, [8.491]
• Braun, G. S. , Nagayama, Y., Maruta, Y., Heymann, F., van Roeyen, C. R., Klinkhammer, B. M., Boor, P., Villa, L., Salant, D. J., Raffetseder, U., Rose-John, S., Ostendorf, T., Floege, J. (2016): Interleukin-6 trans-signaling drives murine crescentic glomerulonephritis.. Journal of the American Society of Nephrology, 27 (1), 132-142, [8.491]
• Schulte, K. , Kunter, U., Moeller, M.J. (2015): The evolution of blood pressure and the rise of mankind.. Nephrology Dialysis Transplantation, 30 (5), 713-723, [4.575]
• Saritas, T. , Kuppe, C., Moeller, M.J. (2015): Progress and controversies in unraveling the glomerular filtration mechanism.. Curr Opin Nephrol Hypertens, 24 (3), 208-216, [3.232]
• Moeller, M. J. , Kuppe C. (2015): Point: Proposing the electrokinetic model.. Perit Dial Int, [1.298]
• Görtz, D. (2015): Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery. Sci Rep, [5.580]
• Borkham-Kamphorst, E. , Alexi, P., Tihaa, L., Haas, U., Weiskirchen, R. (2015): Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.. Biochem Biophys Res, Commun 457, 307-313, [2.300]
• Borkham-Kamphorst, E. , Meurer, S. K., Van de Leur, E., Haas, U., Tihaa, L., Weiskirchen, R. (2015): PDGF-D signalling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type α and β.. Cell Signal, 27, 1305-1314, [4.320]
• Boor, P , Perkuhn, M., Weibrecht, M., Zok, S., Martin, I. V., Gieseke, J., Schoth, F., Ostendorf, T., Kuhl, C., Floege, J. (2015): Diffusion-weighted MR imaging does not reflect kidney fibrosis in rat model of fibrosis.. JMRI, 1002/jmri, 24853, [2.510]
• Kuppe, C. , Gröne, H. J., Ostendorf, T., van Kuppevelt, T. H., Boor, P., Floege, J., Smeets, B., Moeller, M. J. (2015): Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis.. Kidney Intdoi, 10.1038, ki.2015.116, [7.683]
• Kukuk, G. M. , Hittatiya, K., Sprinkart, A. M., Eggers, H., Gieseke, J., Block, W., Moeller, P., Willinek, W. A., Spengler, U., Trebicka, J., Fischer, H. P., Schild, H. H., Träber, F. (2015): Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis. Eur Radiol, , [Epub ahead of print], [3.640]
• Djudjaj, S , Lue, H. J., Rong, S., Papasotiriou, M., Klinkhammer, B. M., Zok, S., Klaener, O., Braun, G. S., Lindenmeyer, M. T., Cohen, C. D., Bucala, R., Tittel, A. P., Kurts, C., Moeller, M. J., Floege, J., Boor, P. (2015): Macrophage migration inhibitory factor mediates proliferative glomerulonephritis via CD74.. J Am Soc Nephrol, , in press, [9.340]
• Schwabl, P. , Payer, B. A., Grahovac, J., Klein, S., Horvatits, T., Mitterhauser, M., Stift, J., Boucher, Y., Trebicka, J., Trauner, M., Angermayr, B., Fuhrmann, V., Reiberger, T., Peck-Radosavljevic, M. (2014): Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats.. Journal of Hepatology, 60(6), 1135-1142, [10.590]
• Nagayama, Y. (2014): Gp130-dependent signaling in the podocyte.. American Journal of Physiology Renal Physiology, 307 (3), F346-F355, [3.390]
• Moeller, M.J , Kuppe C. (2014): Glomerular disease: the role of parietal epithelial cells in hyperplastic lesions. Nature Reviews Nephrology, 10(11), 615-6, [9.463]
• Moeller, M. J. , Smeets, B. (2014): Role of Parietal Epithelial Cells in Kidney Injury: The Case of Rapidly Progressing Glomerulonephritis and Focal and Segmental Glomerulosclerosis. Nephron Experimental Nephrology, 126 (2), 97, [1.531]
• Endlich N. , Simon O, Göpferich A, Wegner H, Moeller MJ, Rumpel E, Kotb AM, Endlich K. (2014): Two-photon microscopy reveals stationary podocytes in living zebrafish larvae. Journal of the American Society of Nephrology, 25(4), 681-6, [8.491]
• Boor, P. , Ostendorf, T., Floege, J. (2014): PDGF and the progression of renal disease. Nephrology Dialysis Transplantation, 29, 45-54, [4.085]
• Berger, K. , Moeller, M. J. (2014): Mechanisms of epithelial repair and regeneration after acute kidney injury.. Semin Nephrol, 34 (4), 394-403, [3.773]
• Alidousty, C. , Rauen, T., Hanssen, L., Wang, Q., Alampour-Rajabi, S., Mertens, P.R., Bernhagen, J., Floege, J., Ostendorf, T., Raffetseder, U. (2014): Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation.. Journal of Biological Chemistry, [4.258]
• Wanner, N. , Hartleben, B., Herbach, N., Goedel, M., Stickel, N., Zeiser, R., Walz, G., Moeller, M. J., Grahammer, F., Huber, T. B. (2014): Unraveling the role of podocyte turnover in glomerular aging and injury.. Journal of American Society of Nephrology, 25(4), 707-716, [8.491]
• Smeets, B. , Stucker, F., Wetzels, J., Brocherigou, I., Ronco, P., Gröne, H. J., D'Agati, V., Fogo, A., van Kuppevelt, T. H., Fischer, H. P., Boor, P., Floege, J., Ostendorf, T., Moeller, M. J. (2014): Detection of activated parietal epithelial cells on the glomerular tuft distinguishes early focal segmental glomerulosclerosis from minimal change disease. The American Journal of Pathology, 184, 3240-3248, [4.206]
• Shankland, S.J. , Smeets, B., Pippin, J. W., Moeller, M. J. (2014): The emergence of the glomerular parietal epithelial cell.. Nat Rev Nephrol, 10(3), 158-173, [9.463]
• Schulte, K. , Berger, K., Boor, P., Jirak, P., Gelman, I. H., Arkull, K. P., Neal, C. R., Kriz, W., Floege, J., Smeets, B., Moeller, M. J. (2014): Origin of Parietal Podocytes in Atubular Glomeruli Mapped by Lineage Tracing. Journal of the American Society of Nephrology, 25(1), 129-141, [8.491]
• Moeller, M. J. , Tanner, G. A. (2014): Reply: podocytes are key-although albumin never reaches the slit diaphragm.. Nature Reviews Nephrology, 10(3), 180, [9.453]
• Berger, K. , Schulte, K., Boor, P., Kuppe, C., van Kuppevelt, T. H., Floege, J., Smeets, B., Moeller, M. J. (2014): The Regenerative Potential of Parietal Epithelial Cells in Adult Mice.. J Am Soc Nephrol., 25(4), 693-705, [8.491]
• Berger, K. , Moeller, M. J. (2014): Podocytopenia, parietal epithelial cells and glomerulosclerosis.. Nephrol Dial Transplant, 29(5), 948-950, [4.085]
• Berger, K. , Bangen, J. M., Hammerich, L., Liedtke, C., Floege, J., Smeets, B., Moeller, M. J. (2014): Origin of regenerating tubular cells after acute kidney injury.. Proc Natl Acad Sci U S A, 111(4), 1533-1538, [9.423]
• Villa, L. , Boor P, Konieczny A, Kunter U, van Roeyen CRC, Denecke B, Gan L, Neusser MA and Cohen CD for the ERCB-Consortium, Eitner F, Scholl T, Ostendorf T, Floege J (2013): Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms. The Journal of Pathology, 229 (5), 672-84, [7.430]
• Seikrit, C. , Henkel C, van Roeyen CRC, Bokemeyer D, Eitner F, Martin IV, Boor P, Ruth Knüchel, Meyer HE, Müller-Newen G, Eriksson U, Floege J, Ostendorf T. (2013): Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol Dial Transplant, Apr;28(4), 889-900, [4.085]
• Hanssen, L. , Alidoutsy, C., Djudjaj, S., Frye, B.C., Rauen, T., Boor, Pr., Mertens, P.R., van Roeyen, C.R., Tacke, F., Heymann, F., Tittel, A.P., Koch, A., Floege, J., Ostendorf, T., Raffetseder, U. (2013): YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo.. The Journal of Immunology, 191(5), 2604-2613, [4.179]
• van Roeyen, C. R. , Zok, S., Pruessmeyer, J., Boor, P., Nagayama, Y., Fleckenstein, S., Cohen, C. D., Eitner, F., Grone, H. J., Ostendorf, T., Ludwig, A., Floege, J. (2013): Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation. Kidney International, 83 (2), 251-263, [7.683]
• Martin, I. V. , Borkham-Kamphorst E, Zok S, van Roeyen CRC, Eriksson U, Boor P, Hiththetiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T. (2013): Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis. The American Journal of Pathology, 182 (1), 107-117, [4.206]
• Tenten, T. , Menzel S, Kunter U, Sicking EM, van Roeyen CVR, Sanden SK, Kaldenbach M, Boor P, Fuss A, Uhlig S, Lanzmich R, Dijkman H, Grepl M, Wild K, Kriz W, Smeets B, Floege J, Moeller MJ. (2013): Albumin is recycled from the primary urine by tubular transcytosis.. Journal of the American Society of Nephrology, 24 (12), 1966-1980, [8.491]
• Smeets, B. , Boor P, Dijkman H, Sharma SV, Jirak P, Khera S, Mooren F, Berger K, Bornemann J, Gelman IH, Floege J, van der Vlag J, Wetzels JFM, Moeller MJ. (2013): Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration. The Journal of Pathology, 229 (5), 645-59, [7.381]
• Moeller, M. J. , Tenten, V. (2013): Renal albumin filtration: alternative models to the standard physical barriers.. Nature Reviews Nephrology, 9 (5), 266-277, [9.463]
• Moeller, M. J. (2013): Novel target in the treatment of RPGN: the activated parietal cell. Nephrology Dialysis Transplantation, 28 (3), 489-492, [4.085]
• Moeller, M. J. (2013): Streaming potentials as novel driving force for capillary permeability. Biophysical Journal, 104 (7), 1395-1396, [3.632]
• Kabgani N, , Moeller M.J. (2013): The terminator mouse: salvation for primary cell culture. Kidney International, 84(5), 866-8, [7.683]
• van Roeyen CRC, Boor P. , Borkham-Kamphorst E, Rong S, Kunter U, Martin IV, Kaitovic A, Fleckenstein S, Perbal B, Weiskirchen R, Ostendorf T, Floege J. (2012): A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and anti-mesangioproliferative effects. American Journal of Pathology, 180, 1979-1990, [4.206]
• van Roeyen, C. R , Ostendorf, T., Floege, J. (2012): The platelet-derived growth factor system in renal disease: An emerging role of endogenous inhibitors. European Journal of Cell Biology, 91 (6-7), 542-551, [4.011]
• Schwartz, V. , Kruttgen, A., Weis, J., Weber, C., Ostendorf, T., Lue, H., Bernhagen, J. (2012): Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF. European Journal of Cell Biology, 91, 435-449, [4.011]
• Ostendorf, T. , Eitner, F., Floege, J. (2012): The PDGF family in renal fibrosis. Pediatr Nephrol, 27, 1041-1050, [2.338]
• Smeets, B. , Moeller, M. J. (2012): Parietal epithelial cells and podocytes in glomerular diseases.. Seminars in Nephrology, 32 (4), 357-367, [3.773]
• Sicking, E. M. , Fuss, A., Uhlig, S., Jirak, P., Dijkman, H., Wetzels, J., Engel, D. R., Urzynicok, T., Heidenreich, S., Kriz, W., Kurts, C., Ostendorf, T., Floege, J., Smeets, B., Moeller, M. J. (2012): Subtotal ablation of parietal epithelial cells induces crescent formation. Journal of the American Society of Nephrology, 23, 629-640, [8.491]
• Sahin, H. , Borkham-Kamphorst, E., Kuppe, C., Zaldivar, M. M., Grouls, C., Al-Samman, M., Nellen, A., Schmitz, P., Heinrichs, D., Berres, M. L., Doleschel, D., Scholten, D., Weiskirchen, R., Moeller, M. J., Kiessling, F., Trautwein, C., Wasmuth, H. E. (2012): Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology, 55 (5), 1610-1619, [11.711]
• Kabgani N. , Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti R, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ. (2012): Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS ONE, 7, [3.057]
• Hausmann, R. , Grepl, M., Knecht, V., Moeller, M. J. (2012): The glomerular filtration barrier function: new concepts. Curr Opin Nephrol Hypertens, 21 (4), 441-449, [3.232]
• Grouls, S. , Iglesias, D. M., Wentzensen, N., Moeller, M. J., Bouchard, M., Kemler, R., Goodyer, P., Niggli, F., Grone, H. J., Kriz, W., Koesters, R. (2012): Lineage specification of parietal epithelial cells requires beta-catenin/Wnt signaling. Journal of the American Society of Nephrology, 23 (1), 63-72, [8.491]
• Fatima, H. , Moeller, M. J., Smeets, B., Yang, H. C., D'Agati, V. D., Alpers, C. E., Fogo, A. B. (2012): Parietal epithelial cell activation marker in early recurrence of FSGS in the transplant. Clinical Journal of the American Society of Nephrology, 7 (11), 1852-1858, [4.657]
• Villa, L. , Boor, P., Konieczny, A., Kunter, U., van Roeyen, C. R., Denecke, B., Gan, L., Kupper, M. B., Hoffmann, K., Eitner, F., Ostendorf, T., Floege, J. (2011): Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis.. Nephrology Dialysis Transplantation, 26 (10), 3131-3143, [4.085]
• Raffetseder, U. , Rauen, T., Boor, P., Ostendorf, T., Hanssen, L., Floege, J., En-Nia, A., Djudjaj, S., Frye, B. C., Mertens, P. R. (2011): Extracellular YB-1 blockade in experimental nephritis upregulates notch-3 receptor expression and signaling. Nephron Experimental Nephrology, 118, 100-108, [1.531]
• Boor, P. , Celec, P., Martin, I. V., Villa, L., Hodosy, J., Klenovicsova, K., Esposito, C., Schafer, S., Albrecht-Kupper, B., Ostendorf, T., Heidland, A., Sebekova, K. (2011): The peroxisome proliferator-activated receptor-alpha agonist, BAY PP1, attenuates renal fibrosis in rats.. Kidney International, 80, 1182-1197, [7.683]
• Hanssen, L. , Frye, B. C., Ostendorf, T., Alidousty, C., Djudjaj, S., Boor, P., Rauen, T., Floege, J., Mertens, P. R., Raffetseder, U. (2011): Y-box binding protein-1 mediates profibrotic effects of calcineurin inhibitors in the kidney. Journal of Immunology, 187 (1), 298-308, [4.179]
• van Roeyen, C. R. , Eitner, F., Boor, P., Moeller, M. J., Raffetseder, U., Hanssen, L., Bucher, E., Villa, L., Banas, M. C., Hudkins, K. L., Alpers, C. E., Ostendorf, T., Floege, J. (2011): Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D. Kidney International, 80 (12), 1292-1305, [7.683]
• Smeets, B. , Kuppe, C., Sicking, E. M., Fuss, A., Jirak, P., van Kuppevelt, T. H., Endlich, K., Wetzels, J. F., Grone, H. J., Floege, J., Moeller, M. J. (2011): Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. Journal of American Society of Nephrology, 11 (7), 1262-1274, [8.491]
• Menzel, S. , Moeller, M. J. (2011): Role of the podocyte in proteinuria. Pediatric Nephrology, 26 (10), 1775-1780, [2.338]
• Kunter, U. , Rong, S., Moeller, M. J., Floege, J. (2011): Mesenchymal stem cells as a therapeutic approach to glomerular diseases: benefits and risks. Kidney International Supplements, 1 (3), 68-73, [7.026]
• Kramann, R. , Moeller, M. J. (2011): The next level of complexity: post-transcriptional regulation by microRNAs. Kidney International, 80 (7), 692-693, [7.683]
• Berger, K. , Moeller, M. J. (2011): Cofilin-1 in the podocyte: a molecular switch for actin dynamics. Internatinal Urology and Nephrology, 43, 273-275, [1.292]
• Moeller, M. J. (2010): Novel insights into the glomerular structure. Dtsch Med Wochenschr, 135 (24), 1232-1236, [0.503]
• Boor, P. , van Roeyen, C. R., Kunter, U., Villa, L., Bucher, E., Hohenstein, B., Hugo, C. P., Eriksson, U., Satchell, S. C., Mathieson, P. W., Eitner, F., Floege, J., Ostendorf, T. (2010): PDGF-C mediates glomerular capillary repair. American Journal of Pathology, 177 (1), 58-69, [4.206]
• Boor, P. , Ostendorf, T., Floege, J. (2010): Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nature Reviews Nephrology, 6 (11), 643-565, [9.463]
• Smeets, B. , Moeller, M. J. (2010): Models of FSGS and minimal change nephropathy. Drug Discovery Today: Disease Models, 7, 3-11, [5.625]
• Moeller, M. J. (2010): Glomerular scarring: can we delay or even reverse glomerulosclerosis by RAAS inhibition?. Nephrology Dialysis Transplantation, 25, 2101-2103, [4.085]
• Hausmann, R. , Kuppe, C., Egger, H., Schweda, F., Knecht, V., Elger, M., Menzel, S., Somers, D., Braun, G., Fuss, A., Uhlig, S., Kriz, W., Tanner, G., Floege, J., Moeller, M. J. (2010): Electrical forces determine glomerular permeability. Journal of American Society of Nephrology, 21 (12), 2053-2058, [8.491]
• Smeets, B. , Uhlig, S., Fuss, A., Mooren, F., Wetzels, J. F., Floege, J., Moeller, M. J. (2009): Tracing the origin of glomerular extracapillary lesions from parietal epithelial cells.. J Am Soc Nephrol, 20, 2604-2615, [8.491]
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