P12 Prof. Dr. Nattermann/ Prof. Dr. Spengler
Role of innate lymphoid cells in liver fibrosis

It is the aim of our project to analyze the role of human innate lymphoid cells (ILCs) in hepatic fibrogenesis. To this end we will analyse alterations of the hepatic ILC pool in liver diseases of different aetiology and study how this relates to progression to liver fibrosis (Task I). These studies will provide the basis for the planned in vitro studies which aim at analysing the cross-talk of ILCs with hepatic stellate cells, the mechanisms involved in these interactions and how these are affected by the surrounding microenvironment (Task II). Finally, we will study how alterations of the intestinal ILC pool in liver disease may contribute to progressive hepatic inflammation and fibrogenesis (Task III). [...]

Publications

• Sharkawy R. E. , Bayoumi A., Metwally M., Mangia A., Berg T., Romero-Gomez M., Abate M. L., Irving W. L., Sheridan D., Dore G. J., Spengler U., Lampertico P., Bugianesi E., Weltman M., Mollison L., Cheng W., Riordan S., Santoro R., Gallego-Durán R., Fischer J., Nattermann J., D'Ambrosio R., McLeod D., Powell E., Latchoumanin O., Thabet K., Najim M. A. M., Douglas M. W., Liddle C., Qiao L., George J., Eslam M.; International Liver Disease Genetics Consortium (ILDGC) (2019): A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms. Sci Rep., 9(1), 1439, [4.011]
• Lutz P. , Jeffery H. C., Jones N., Birtwistle J., Kramer B., Nattermann J., Spengler U., Strassburg C. P., Adams D. H., Oo Y. H. (2019): NK Cells in Ascites From Liver Disease Patients Display a Particular Phenotype and Take Part in Antibacterial Immune Response. Front Immunol, 10, 1838, [4.716]
• Langhans B. , Nischalke H. D., Krämer B., Dold L., Lutz P., Mohr R., Vogt A., Toma M., Eis-Hübinger A. M., Nattermann J., Strassburg C. P., Gonzalez-Carmona M. A., Spengler U. (2019): Role of regulatory T cells and checkpoint inhibition in hepatocellular carcinoma. Cancer Immunol Immunother, 68(12), 2055-2066, [4.900]
• Gonzalez-Carmona M. A. , Bolch M., Jansen C., Vogt A., Sampels M., Mohr R. U., van Beekum K., Mahn R., Praktiknjo M., Nattermann J., Trebicka J., Branchi V., Matthaei H., Manekeller S., Kalff J. C., Strassburg C. P., Weismüller T. J. (2019): Combined photodynamic therapy with systemic chemotherapy for unresectable cholangiocarcinoma. Aliment Pharmacol Ther, 49(4), 437-447, [7.357]
• Dold L. , Nielsen M. J., Praktiknjo M., Schwarze-Zander C., Boesecke C., Schierwagen R., Mohr R., Wasmuth J. C., Jansen C., Bischoff J., Rockstroh J. K., Karsdal M. A., Spengler U., Trebicka J., Leeming D. J. (2019): Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART. PLoS One, 14(7), e0219526, [2.776]
• Lutz P , M Haimid M, Pohlmann A, Lehmann J, Jansen C, Schierwagen R, Klein S, Strassburg CP, Spengler U, Trebicka J. (2017): MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis. Scientific Reports, 7, 40556, [5.228]
• Schwab S , Lehmann J, Lutz P, Jansen C, Appenrodt B, Lammert F, Strassburg CP, Spengler U, Nischalke HD, Trebicka J. (2017): Influence of genetic variations in the SOD1 gene on the development of ascites and spontaneous bacterial peritonitis in decompensated liver cirrhosis.. European Journal of Gastroenterology & Hepatology, 29(7), 800-804, [2.093]
• Klein S , Hinüber C, Hittatiya K, Schierwagen R, Uschner FE, Strassburg CP, Fischer HP, Spengler U, Trebicka J. (2016): Novel Rat Model of Repetitive Portal Venous Embolization Mimicking Human Non-Cirrhotic Idiopathic Portal Hypertension. PLoS One, 11(9)PLoS One, e0162144, [3.057]
• Schon H.T. , Bartneck M., Borkham-Kamphorst E., Nattermann J., Lammers T., Tacke F., Weiskirchen R. (2016): Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis. Frontiers in Pharmacology, 7, 33, [4.418]
• Kokordelis, P. , Krämer. B., Boesecke, C., Voigt, E., Ingiliz, P., Glässner, A., Wolter, F., Strassburg, C.P., Spengler, U., Rockstroh, J.K., Nattermann, J. (2015): CD3(+)CD56(+) Natural Killer-Like T Cells Display Anti-HCV Activity but Are Functionally Impaired in HIV(+) Patients With Acute Hepatitis C.. Journal of Acquired Immune Deficiency Syndrome, 70 (4), 338-346, [3.806]
• Goeser F. (2015): HIV mono-infection is associated with an impaired anti-HCV activity of NK cells. AIDS, [5.550]
• Kukuk, G. M. , Hittatiya, K., Sprinkart, A. M., Eggers, H., Gieseke, J., Block, W., Moeller, P., Willinek, W. A., Spengler, U., Trebicka, J., Fischer, H. P., Schild, H. H., Träber, F. (2015): Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis. Eur Radiol, , [Epub ahead of print], [3.640]
• Anadol, E. P. , Schierwagen, R., Elfimova, N., Tack, K., Schwarze-Zander, C., Eischeid, H., Noetel, A., Boesecke, C., Jansen, C., Dold, L., Wasmuth, J. C., Strassburg, C. P., Spengler, U., Rockstroh, J. K., Odenthal, . (2015): Circulating microRNAs as a marker for liver injury in human immunodeficiency virus patients.. Hepatology, 61(1), 46-55, [11.050]
• Wolter, F. , Glassner, A., Kramer, B., Korkordelis, P., Finneman, C., Kacmarek, D., Goeser, F., Lutz, P., Nischalke, H. D., Strassburg, C. P., Spengler, U., Nattermann. (2015): Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infection.. Journal of Hepatology, 63 (6), 1334-41, [10.590]
• Eslam, M. , Hashem, A. M., Leung, R., Romero-Gomez, M., Berg, T., Dore, G. J., Chan, H. L., Irving, W. L., Sheridan, D., Abate, M. L., Adams, L. A., Mangia, A., Weltman, M., Burgianesi, E., Spengler, U., Shaker, O., Fischer, J., Mollison, L., Cheng, W., Powell, E., Nattermann, J., Riordan, S., McLeod, D., Armstrong, N. J., Douglas, M. W., Liddle, C., Booth, D. R., George, J., Ahlenstiel, G., International Hepatitis, C. G. C. (2015): Interferon-lambda rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nat Commun, 6, 6422,
• Langhans, B. , Alwan, A. W., Kramer, B., Glassner, A., Lutz, P., Strassburg, C. P., Nattermann, J., Spengler, U. (2015): Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type.. J Hepatol, 62, 398-404, [10.590]
• Leeming, D. J. , Anadol, E., Schierwagen, R., Karsdal, M. A., Byrjalsen, I., Nielsen, M. J., Schwarzer-Zander, C., Boesecke, C., Bendtsen, F., Møller , S., Strassburg, C. P., Spengler, U., Krag, A., Rockstroh, J., Trebicka, J. K. (2014): Combined antiretroviral therapy attenuates hepatic extracellular matrix remodeling in HIV patients assessed by novel protein fingerprint markers.. AIDS, 28(14), 2081-2090, [4.407]
• Nischalke, H.D. , Lutz P, Krämer B, Söhne J, Müller T, Rosendahl J, Fischer J, Berg T, Hittatiya K, Fischer HP, Soyka M, Semmo N, Nattermann J, Sauerbruch T, Strassburg CP, Stickel F, Spengler U. (2014): A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.. Journal of Hepatology, 61 (5), 1073-1079, [10.590]
• Kokordelis, P. , Kramer, B., Korner, C., Boesecke, C., Voigt, E., Ingiliz, P., Glassner, A., Eisenhardt, M., Wolter, F., Kaczmarek, D., Nischalke, H. D., Rockstroh, J. K., Spengler, U., Nattermann, J. (2014): An effective interferon-gamma-mediated inhibition of hepatitis C virus replication by natural killer cells is associated with spontaneous clearance of acute hepatitis C in human immunodeficiency virus-positive patients. Hepatology, 59 (3), 814-827, [11.711]
• Granzow, M. , Schierwagen, R., Klein, S., Kowallick, B., Huss, S., Linhart, M., Mazar, I. G., Görtzen, J., Vogt, A., Schildberg, F. A., Gonzalez-Carmona, M. A., Wojtalla, A., Krämer, B., Nattermann, J., Siegmund, S. V., Werner, N., Fürst, D. O., Laleman, W., Knolle, P., Shah, V. H., Sauerbruch, T., Trebicka, J. (2014): Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology, 60(1), 334-348, [11.711]
• Trebicka, J. , Krag A, Gansweid S, Schiedermaier P, Strunk HM, Fimmers R, Strassburg CP, Bendtsen F, Møller S, Sauerbruch T, Spengler U. Soluble (2013): Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension.. PLoS One, 8(12), [3.057]
• Nischalke, H.D , Berger, C., Lutz, P., Langhans, B., Wolter., Eisenhardt, M., Krämer, B., Kokordelis, P., Glässner, A., Müller, T., Rosendahl, J., Berg, T., Grünhgae, F., Leifeld, L., Soyka, M., Nattermann, J. Sauerbruch, T., Stickel, F., Spengler, U. (2013): Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent. PLoS One, 8 (11), [3.057]
• Langhans, B. , Krämer, B., Louis, M., Nischalke, H.D., Hüneburg, R., Staratschek-Jox, A., Odenthal, M., Manekeller, S., Schepke, M., Kalff, J., Fischer, H.P., Schultze, J.L., Spengler, U. (2013): Intrahepatic IL-8 producing Foxp3⁺CD4⁺ regulatory T cells and fibrogenesis in chronic hepatitis C.. Journal of Hepatology, 59 (2), 229-235, [10.590]
• Kellner, P. , Anadol, E., Huneburg, R., Hundt, F., Bos, D., Klein, B., Woitas, R. P., Spengler, U., Sauerbruch, T., Trebicka, J. (2013): The effect of hemodialysis on liver stiffness measurement: a single-center series.. European Journal of Gastroenterol & Hepatology, 25 (3), 368-372, [2.093]
• Glässner, A. , Eisenhardt, M., Kokordelis, P., Kramer, B., Wolter, F., Nischalke, H. D., Boesecke, C., Sauerbruch, T., Rockstroh, J. K., Spengler, U., Nattermann, J. (2013): Impaired CD4⁺ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients. Journal of Hepatology, 59 (3), 427-433, [10.590]
• Nischalke, H. D. , Coenen, M., Berger, C., Aldenhoff, K., Muller, T., Berg, T., Kramer, B., Korner, C., Odenthal, M., Schulze, F., Grunhage, F., Nattermann, J., Sauerbruch, T., Spengler, U. (2012): The toll-like receptor 2 (TLR2) -196 to -174 del/ins polymorphism affects viral loads and susceptibility to hepatocellular carcinoma in chronic hepatitis C. International Journal of Cancer, 130 (6), 1470-1475, [5.531]
• Nischalke, H. D. , Berger, C., Luda, C., Muller, T., Berg, T., Coenen, M., Kramer, B., Korner, C., Trebicka, J., Grunhage, F., Lammert, F., Nattermann, J., Sauerbruch, T., Spengler, U. (2012): The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients. Journal of Hepatology, 56, 758-764, [10.590]
• Neukam, K. , Camacho, A., Caruz, A., Rallon, N., Torres-Cornejo, A., Rockstroh, J. K., Macias, J., Rivero, A., Benito, J. M., Lopez-Cortes, L. F., Nattermann, J., Gomez-Mateos, J., Soriano, V., Pineda, J. A. (2012): Prediction of response to pegylated interferon plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients using HCV genotype, IL28B variations, and HCV-RNA load. Journal of Hepatology, 56, 788-794, [10.590]
• Kramer, B. , Korner, C., Kebschull, M., Glassner, A., Eisenhardt, M., Nischalke, H. D., Alexander, M., Sauerbruch, T., Spengler, U., Nattermann, J. (2012): NKp46(High) expression defines a NK cell subset that is potentially involved in control of HCV replication and modulation of liver fibrosis. Hepatology, 56(4), 1201-13, [11.711]
• Korner, C. , Riesner, K., Kramer, B., Eisenhardt, M., Glassner, A., Wolter, F., Berg, T., Muller, T., Sauerbruch, T., Nattermann, J., Spengler, U., Nischalke, H. D. (2012): TRAIL receptor I (DR4) polymorphisms C626G und A638C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients. BMC Cancer, 12, 85, [3.265]
• Klein, S. , Klosel, J., Schierwagen, R., Korner, C., Granzow, M., Huss, S., Mazar, I. G., Weber, S., van den Ven, P. F., Pieper-Furst, U., Furst, D. O., Nattermann, J., Lammert, F., Sauerbruch, T., Trebicka, J. (2012): Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats. Laboratory Investigation, 92, 1440-1450, [4.202]
• Glassner, A. , Eisenhardt, M., Kramer, B., Korner, C., Coenen, M., Sauerbruch, T., Spengler, U., Nattermann, J. (2012): NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner. Laboratory Investigation, 92, 967-977, [4.202]
• Zimmermann, H. W. , Seidler, S., Gassler, N., Nattermann, J., Luedde, T., Trautwein, C., Tacke, F. (2011): Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS One, 6 (6), e21381, [3.057]
• Vogel, M. , Friedrich, O., Luchters, G., Holleczek, B., Wasmuth, J. C., Anadol, E., Schwarze-Zander, C., Nattermann, J., Oldenburg, J., Sauerbruch, T., Rockstroh, J. K., Spengler, U. (2011): Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence. European Journal of Medical Research, 16 (3), 101-107, [1.684]
• Trebicka, J. , Krag, A., Gansweid, S., Appenrodt, B., Schiedermaier, P., Sauerbruch, T., Spengler, U. (2011): Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt. European Journal of Gastroenterology & Hepatology, 23 (12), 1218-1225, [2.093]
• Suppiah, V. , Gaudieri, S., Armstrong, N. J., O'Connor, K. S., Berg, T., Weltman, M., Abate, M. L., Spengler, U., Bassendine, M., Dore, G. J., Irving, W. L., Powell, E., Hellard, M., Riordan, S., Matthews, G., Sheridan, D., Nattermann, J., Smedile, A., Muller, T., Hammond, E., Dunn, D., Negro, F., Bochud, P. Y., Mallal, S., Ahlenstiel, G., Stewart, G. J., George, J., Booth, D. R., International Hepatitis, C. G. C. (2011): IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study. PLoS Med, 8 (9), e1001092, [13.585]
• Ruhl, M. , Knuschke, T., Schewior, K., Glavinic, L., Neumann-Haefelin, C., Chang, D. I., Klein, M., Heinemann, F. M., Tenckhoff, H., Wiese, M., Horn, P. A., Viazov, S., Spengler, U., Roggendorf, M., Scherbaum, N., Nattermann, J., Hoffmann, D., Timm, J., East German, H. C. V. S. G. (2011): CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins. Gastroenterology, 140 (7), 2064-2073, [18.187]
• Nischalke, H. D. , Berger, C., Luda, C., Berg, T., Muller, T., Grunhage, F., Lammert, F., Coenen, M., Kramer, B., Korner, C., Vidovic, N., Oldenburg, J., Nattermann, J., Sauerbruch, T., Spengler, U. (2011): The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. PLoS One, 6, e27087, [3.057]
• Neukam, K. , Nattermann, J., Rallon, N., Rivero, A., Caruz, A., Macias, J., Vogel, M., Benito, J., Camacho, A., Mira, J., Schwarze-Zander, C., Barreiro, P., Martinez, A., Rockstroh, J., Soriano, V., Pineda, J. (2011): Different distributions of hepatitis C virus genotypes among HIV-infected patients with acute and chronic hepatitis C according to interleukin-28B genotype. HIV Medicine, 12 (8), 487-493, [3.341]
• Nattermann, J. , Vogel, M., Nischalke, H. D., Danta, M., Mauss, S., Stellbrink, H. J., Baumgarten, A., Mayr, C., Bruno, R., Tural, C., Klausen, G., Clotet, B., Naumann, U., Lutz, T., Rausch, M., Schewe, K., Bienek, B., Haerter, G., Sauerbruch, T., Rockstroh, J. K., Spengler, U. (2011): Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C. Journal of Infectious Diseases, 203 (5), 595-601, [6.344]
• Nattermann, J. , Timm, J., Nischalke, H. D., Olbrich, A., Michalk, M., Tillmann, H. L., Berg, T., Wedemeyer, H., Tenckhoff, H., Wiese, M., Kullig, U., Gobel, U., Capka, E., Schiefke, I., Guthof, W., Grungreiff, K., Konig, I., Roggendorf, M., Sauerbruch, T., Spengler, U., East German, H. C. V. S. G. (2011): The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Delta32 mutation. Journal of Hepatology, 55 (6), 1201-1206, [10.590]
• Nischalke, H. D. , Berger, C., Aldenhoff, K., Thyssen, L., Gentemann, M., Grunhage, F., Lammert, F., Nattermann, J., Sauerbruch, T., Spengler, U., Appenrodt, B. (2011): Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosis. Journal of Hepatology, 55 (5), 1010-1016, [10.590]
• Nattermann, J. (2011): NK cells in acute hepatitis C. Journal of Hepatology, 55 (2), 265-267, [10.590]
• Langhans, B. , Kupfer, B., Braunschweiger, I., Arndt, S., Schulte, W., Nischalke, H. D., Nattermann, J., Oldenburg, J., Sauerbruch, T., Spengler, U. (2011): Interferon-lambda serum levels in hepatitis C. Journal of Hepatology, 54 (5), 859-865, [10.590]
• Kramer, B. , Eisenhardt, M., Glassner, A., Korner, C., Sauerbruch, T., Spengler, U., Nattermann, J. (2011): Do lambda-IFNs IL28A and IL28B act on human natural killer cells?. Proceedings of the National Academy of Sciences of the U S A, 108 (34), 519-520, [9.423]
• Korner, C. , Tolksdorf, F., Riesner, K., Kramer, B., Schulte, D., Nattermann, J., Rockstroh, J. K., Spengler, U. (2011): Hepatitis C coinfection enhances sensitization of CD4(+) T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients. Antiviral Therapy, 16, 1047-1055, [2.916]
• Sibbing, B. , Nattermann, J. (2011): Hepatitis C virus infection and genetic susceptibility to therapy. Journal of Gastrointestinal and Liver Diseases, 20 (4), 397-406, [1.891]
• Lange, C. M. , Roomp, K., Dragan, A., Nattermann, J., Michalk, M., Spengler, U., Weich, V., Lengauer, T., Zeuzem, S., Berg, T., Sarrazin, C. (2010): HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection. Journal of Hepatology, 53 (6), 1022-1028, [10.590]
• Grunhage, F. , Wasmuth, J. C., Herkenrath, S., Vidovic, N., Goldmann, G., Rockstroh, J., Lammert, F., Oldenburg, J., Sauerbruch, T., Spengler, U. (2010): Transient elastography discloses identical distribution of liver fibrosis in chronic hepatitis C between HIV-negative and HIV-positive patients on HAART. European Journal of Medical Research, 15 (4), 139-144, [1.684]
• Coenen, M. , Nattermann, J. (2010): The role of CCR5 in HCV infection. European Journal of Medical Research, 15, 97-101, [1.684]
• Vidovic, N. , Lochowsky, R. S., Goldmann, G., Rockstroh, J., Wasmuth, J. C., Spengler, U., Sauerbruch, T., Lammert, F., Oldenburg, J., Grunhage, F. (2010): Correlation of transient elastography with APRI and FIB-4 in a cohort of patients with congenital bleeding disorders and HCV or HIV/HCV coinfection. Haemophilia, 16 (5), 778-785, [2.673]
• Langhans, B. , Braunschweiger, I., Arndt, S., Schulte, W., Satoguina, J., Layland, L. E., Vidovic, N., Hoerauf, A., Oldenburg, J., Sauerbruch, T., Spengler, U. (2010): Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C.. Clinical Science (London), 119, 97-109, [5.016]
• Zimmermann, H. W. , Seidler, S., Nattermann, J., Gassler, N., Hellerbrand, C., Zernecke, A., Tischendorf, J. J., Luedde, T., Weiskirchen, R., Trautwein, C., Tacke, F. (2010): Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One, 5 (6), e11049, [3.057]
• Tillmann, H. L. , Thompson, A. J., Patel, K., Wiese, M., Tenckhoff, H., Nischalke, H. D., Lokhnygina, Y., Kullig, U., Gobel, U., Capka, E., Wiegand, J., Schiefke, I., Guthoff, W., Grungreiff, K., Konig, I., Spengler, U., McCarthy, J., Shianna, K. V., Goldstein, D. B., McHutchison, J. G., Timm, J., Nattermann, J., German Anti, D. S. G. (2010): A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology, 139 (5), 1586-1592, [18.187]
• Nischalke, H. D. , Vogel, M., Mauss, S., Baumgarten, A., Lutz, T., Danta, M., Naumann, U., Coenen, M., Sauerbruch, T., Rockstroh, J. K., Spengler, U., Nattermann, J. (2010): The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection.. AIDS, 24, 2001-2007, [4.407]
• Grunhage, F. , Nattermann, J., Gressner, O. A., Wasmuth, H. E., Hellerbrand, C., Sauerbruch, T., Spengler, U., Lammert, F. (2010): Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C. Journal of Hepatology, 52 (2), 153-159, [10.590]
• Grunhage, F. , Nattermann, J. (2010): Viral hepatitis: human genes that limit infection. Best Pract Res Clin Gastroenterol, 24 (5), 709-723, [3.897]
• Schulte, D. , Vogel, M., Langhans, B., Kramer, B., Korner, C., Nischalke, H. D., Steinberg, V., Michalk, M., Berg, T., Rockstroh, J. K., Sauerbruch, T., Spengler, U., Nattermann, J. (2009): The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells. J Infect Dis, 200, 1397-1401, [6.344]
• Nattermann, J. , Tacke, F. (2009): The structure behind diversity: covariance networks in hepatitis C virus sequences are associated with treatment response.. Hepatology, 49, 1767-1769, [11.711]
• Kramer, B. , Schulte, D., Korner, C., Zwank, C., Hartmann, A., Michalk, M., Sohne, J., Langhans, B., Nischalke, H. D., Coenen, M., Mohl, C., Vogt, A., Hennenberg, M., Sauerbruch, T., Spengler, U., Nattermann, J. (2009): Regulation of NK cell trafficking by CD81.. Eur J Immunol, 39, 3447-3458, [4.179]
• Ahlenstiel, G. , Woitas, R. P., Iwan, A., Nattermann, J., Feldmann, G., Rockstroh, J. K., Oldenburg, J., Kupfer, B., Sauerbruch, T., Spengler, U. (2009): Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia. Immunol Invest, 38, 284-296, [1.780]