P22 PD Dr. Zimmermann
Defining HGF/c-Met dependent diagnostic markers and novel therapeutic targets in NASH-development

The purpose of the here presented proposal is to investigate mechanisms of NASH fibrosis development in mice and humans. We will delineate the role of the HGF/c-Met pathway on a cellular level by using conditional c-Met knockout mice and by analysing the interaction with the anti-oxidative stress response. Findings from the mouse system will be translated into the human system with the aim to define novel genes, which are involved in the pathogenesis of the diseases.