P33 Prof. Dr. Dr. Lammers
Imaging biomarkers for staging and treatment monitoring of liver and kidney fibrosis

The aim of this project is to develop molecular imaging agents which specifically recognize elastin, collagen and the platelet-derived growth factor receptor (PDGFR). Initial evidence for elastin imaging has already been obtained, using magnetic resonance imaging and the elastin-specific agent ESMA. Using optical imaging, we have also already provided proof-of-principle for fibrosis visualization using the collagen-binding agent CNA35 and the PDGFR-binding peptide BiPPB. These findings will now be validated in multiple models, and probe properties and imaging protocols will be optimized. Towards the end of the project, efforts will be extended towards positron emission tomography, to facilitate potential clinical translation.