P33 Prof. Dr. Dr. Lammers
Imaging biomarkers for staging and treatment monitoring of liver and kidney fibrosis

The aim of this project is to develop molecular imaging agents which specifically recognize elastin, collagen and the platelet-derived growth factor receptor (PDGFR). Initial evidence for elastin imaging has already been obtained, using magnetic resonance imaging and the elastin-specific agent ESMA. Using optical imaging, we have also already provided proof-of-principle for fibrosis visualization using the collagen-binding agent CNA35 and the PDGFR-binding peptide BiPPB. These findings will now be validated in multiple models, and probe properties and imaging protocols will be optimized. Towards the end of the project, efforts will be extended towards positron emission tomography, to facilitate potential clinical translation. [...]

Publications

• Baues M. , Klinkhammer B. M., Ehling J., Gremse F., van Zandvoort M. A. M. J., Reutelingsperger C. P. M., Daniel C., Amann K., Bábíčková J., Kiessling F., Floege J., Lammers T., Boor P. (2020): A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. Kidney International, 97(3), 609-614, [8.306]
• Sun Q. , Baues M., Klinkhammer B. M., Ehling J., Djudjaj S., Drude N. I., Daniel C., Amann K., Kramann R., Kim H., Saez-Rodriguez J., Weiskirchen R., Onthank D. C., Botnar R. M., Kiessling F., Floege J., Lammers T., Boor P. (2019): Elastin imaging enables non-invasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med, 11, 486, [17.161]
• Mossanen J. C. , Kohlhepp M., Wehr A., Krenkel O., Liepelt A., Roeth A. A., Möckel D., Heymann F., Lammers T., Gassler N., Hermann J., Jankowski J., Neumann U. P., Luedde T., Trautwein C., Tacke F. (2019): CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell-Dependent Control of Senescence. Gastroenterology, 156(6), 1877-1889, [20.773]
• Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D.C., Drescher H.K. (2019): The inhibitory T cell receptors PD1 and 2B4 are differentially regulated on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis. Front Pharmacol, 10, 244, [3.845]
• Hansel C. , Erschfeld S., Baues M., Lammers T., Weiskirchen R., Trautwein C., Kroy D. C., Drescher H. K. (2019): The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis. frontiers in Pharmacology, [3.845]
• Bartneck M. , Schrammen P. L., Möckel D., Govaere O., Liepelt A., Krenkel O., Ergen C., McCain M. V., Eulberg D., Luedde T., Trautwein C., Kiessling F., Reeves H., Lammers T., Tacke F. (2019): The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers. Cell Mol Gastroenterol Hepatol, 7(2), 371-390, [6.850]
• Warzecha K. T. , Bartneck M., Möckel D., Appold L., Ergen C., Al Rawashdeh W., Gremse F., Niemietz P. M., Jahnen‐Dechent W., Trautwein C., Kiessling F., Lammers T., Tacke F. (2018): Targeting and Modulation of Liver Myeloid Immune Cells by Hard-Shell Microbubbles. Adv Biosyst, 2(5), 1-24, [2.855]
• Uschner F. E. , Schueller F., Nikolova I., Klein S., Schierwagen R., Magdaleno F., Gröschl S., Loosen S., Ritz T., Roderburg C., Vucur M., Kristiansen G., Lammers T., Luedde T., Trebicka J. (2018): The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension. Oncotarget, 9(90), 36220-36237, [5.168]
• Gauthier A. , Fisch A., Seuwen K., Baumgarten B., Ruffner H., Aebi A., Rausch M., Bartneck M., Weiskirchen R., Tacke F., Storm G., Lammers T., Ludwig M.-G. (2018): Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials, 178, 481-495, [10.273]
• Buhl, E. M. , Djudjaj, S., Babickova, J., Klinkhammer, B. M., Folestad, E., Borkham-Kamphorst, E., Weiskirchen, R., Hudkins, K., Alpers, C. E., Eriksson, U., Floege, J., Boor, P. (2016): Role of PDGF-D in healthy and fibrotic kidneys.. Kidney Int, 89, 848-861, [7.683]
• Schon H.T. , Bartneck M., Borkham-Kamphorst E., Nattermann J., Lammers T., Tacke F., Weiskirchen R. (2016): Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis. Frontiers in Pharmacology, 7, 33, [4.418]
• Ehling, J. , Bábíčková, J., Gremse, F., Klinkhammer, B. M., Baetke, S. H., Knuechel, R., Kiessling, F., Floege, J., Lammers, T., Boor, P. (2016): Quantitative micro-CT imaging of micro-to-macrovascular dysfunction in progressive kidney diseases. Journal of the American Society of Nephrology], 27(2), 520–532, [8.491]
• Bartneck M. , Fech V., Ehling J., Govaere O., Theresa Warzecha K., Hittatiya K., Vucur M., Gautheron J., Luedde T., Trautwein C., Lammers T., Roskams T., Jahnen-Dechent W., Tacke F. (2016): Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease. Hepatology, 63(4), 1310-24,
• Ehling, J. , Bartneck, M., Wie, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., Kiessling, F., Trautwein, C., Lammers, T., Tacke, F. (2014): CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.. Gut, 63(12), 1960-71, [14.921]
• Bartneck, M. , Peters, F. M., Warzecha, K. T., Bienert, M., van Bloois, L., Trautwein, C., Lammers, T., Tacke, F. (2014): Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages.. Nanomedicine, 10(6), 1209-1220, [5.671]
• Ehling, J. , Bartnack, M., Fech, V., Butzbach, P., Cesati, R., Botnas, R., Lammers,T., Tacke, F. (2013): Elastin-based molecular MRI of liver fibrosis.. Hepatology, 58 (4), 1517-1518, [11.711]
• Bartneck, M. , Ritz, T., Keul, H. A., Wambach, M., Bornemann, J., Gbureck, U., Ehling, J., Lammers, T., Heymann, F., Gassler, N., Ludde, T., Trautwein, C., Groll, J., Tacke, F. (2012): Peptide-functionalized gold nanorods increase liver injury in hepatitis. ACS Nano, 6 (10), 8767-8777, [13.334]